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Long-term intake of vegetables and fruits and subjective cognitive function in US men.
Neurology. 2019 Jan 01; 92(1):e63-e75.Neur

Abstract

OBJECTIVE

To evaluate the prospective association of long-term intake of vegetables and fruits with late-life subjective cognitive function (SCF).

METHODS

Among 27,842 men with a mean age of 51 years in 1986, we used multinomial logistic regression to examine the relation of vegetable and fruit consumption to future SCF. Average dietary intake was calculated from 5 repeated food frequency questionnaires collected every 4 years until 2002. SCF score was assessed twice (2008 and 2012) using a 6-item questionnaire; validity was supported by strong associations with APO ε4 genotype. We categorized the average of the 2 scores as good, moderate, and poor SCF.

RESULTS

Higher intakes of total vegetables, total fruits, and fruit juice were each significantly associated with lower odds of moderate or poor SCF after controlling for major nondietary factors and total energy intake. The association with total fruit intake was weaker after further adjusting for major dietary factors. In this model, the multivariate odds ratios (95% confidence intervals) for vegetable intake (top vs bottom quintile) were 0.83 (0.76-0.92), p trend <0.001 for moderate SCF and 0.66 (0.55-0.80), p trend <0.001 for poor SCF. For orange juice, compared to <1 serving/mo of intake, daily consumption was associated with a substantially lower odds of poor SCF (0.53 [0.43-0.67], p trend <0.001). Higher consumption of vegetables and fruits 18 to 22 years before SCF assessment was associated with lower odds of poor SCF independent of more proximal intake.

CONCLUSION

Our findings support a long-term beneficial role of vegetable, fruit, and orange juice consumption on SCF.

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Authors+Show Affiliations

Yuan C
From the Departments of Nutrition (C.Y., E.F., A.A., W.C.W.) and Epidemiology (A.A., O.I.O., F.G., W.C.W.), Harvard T.H. Chan School of Public Health, Boston; Channing Division of Network Medicine (C.Y., E.F., A.A., O.I.O., F.G., W.C.W.) and Department of Psychiatry (O.I.O.), Brigham and Women's Hospital and Harvard Medical School, Boston; and Harvard Medical School (A.B.), Boston, MA. Chy478@mail.harvard.edu.
Fondell E
From the Departments of Nutrition (C.Y., E.F., A.A., W.C.W.) and Epidemiology (A.A., O.I.O., F.G., W.C.W.), Harvard T.H. Chan School of Public Health, Boston; Channing Division of Network Medicine (C.Y., E.F., A.A., O.I.O., F.G., W.C.W.) and Department of Psychiatry (O.I.O.), Brigham and Women's Hospital and Harvard Medical School, Boston; and Harvard Medical School (A.B.), Boston, MA.
Bhushan A
From the Departments of Nutrition (C.Y., E.F., A.A., W.C.W.) and Epidemiology (A.A., O.I.O., F.G., W.C.W.), Harvard T.H. Chan School of Public Health, Boston; Channing Division of Network Medicine (C.Y., E.F., A.A., O.I.O., F.G., W.C.W.) and Department of Psychiatry (O.I.O.), Brigham and Women's Hospital and Harvard Medical School, Boston; and Harvard Medical School (A.B.), Boston, MA.
Ascherio A
From the Departments of Nutrition (C.Y., E.F., A.A., W.C.W.) and Epidemiology (A.A., O.I.O., F.G., W.C.W.), Harvard T.H. Chan School of Public Health, Boston; Channing Division of Network Medicine (C.Y., E.F., A.A., O.I.O., F.G., W.C.W.) and Department of Psychiatry (O.I.O.), Brigham and Women's Hospital and Harvard Medical School, Boston; and Harvard Medical School (A.B.), Boston, MA.
Okereke OI
From the Departments of Nutrition (C.Y., E.F., A.A., W.C.W.) and Epidemiology (A.A., O.I.O., F.G., W.C.W.), Harvard T.H. Chan School of Public Health, Boston; Channing Division of Network Medicine (C.Y., E.F., A.A., O.I.O., F.G., W.C.W.) and Department of Psychiatry (O.I.O.), Brigham and Women's Hospital and Harvard Medical School, Boston; and Harvard Medical School (A.B.), Boston, MA.
Grodstein F
From the Departments of Nutrition (C.Y., E.F., A.A., W.C.W.) and Epidemiology (A.A., O.I.O., F.G., W.C.W.), Harvard T.H. Chan School of Public Health, Boston; Channing Division of Network Medicine (C.Y., E.F., A.A., O.I.O., F.G., W.C.W.) and Department of Psychiatry (O.I.O.), Brigham and Women's Hospital and Harvard Medical School, Boston; and Harvard Medical School (A.B.), Boston, MA.
Willett WC
From the Departments of Nutrition (C.Y., E.F., A.A., W.C.W.) and Epidemiology (A.A., O.I.O., F.G., W.C.W.), Harvard T.H. Chan School of Public Health, Boston; Channing Division of Network Medicine (C.Y., E.F., A.A., O.I.O., F.G., W.C.W.) and Department of Psychiatry (O.I.O.), Brigham and Women's Hospital and Harvard Medical School, Boston; and Harvard Medical School (A.B.), Boston, MA.

MeSH

AdultAgedCognitionCognition DisordersFruitHumansLongitudinal StudiesMaleMiddle AgedNeuropsychological TestsOdds RatioSurveys and QuestionnairesUnited StatesVegetables

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

30464030

Citation

Yuan, Changzheng, et al. "Long-term Intake of Vegetables and Fruits and Subjective Cognitive Function in US Men." Neurology, vol. 92, no. 1, 2019, pp. e63-e75.
Yuan C, Fondell E, Bhushan A, et al. Long-term intake of vegetables and fruits and subjective cognitive function in US men. Neurology. 2019;92(1):e63-e75.
Yuan, C., Fondell, E., Bhushan, A., Ascherio, A., Okereke, O. I., Grodstein, F., & Willett, W. C. (2019). Long-term intake of vegetables and fruits and subjective cognitive function in US men. Neurology, 92(1), e63-e75. https://doi.org/10.1212/WNL.0000000000006684
Yuan C, et al. Long-term Intake of Vegetables and Fruits and Subjective Cognitive Function in US Men. Neurology. 2019 01 1;92(1):e63-e75. PubMed PMID: 30464030.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term intake of vegetables and fruits and subjective cognitive function in US men. AU - Yuan,Changzheng, AU - Fondell,Elinor, AU - Bhushan,Ambika, AU - Ascherio,Alberto, AU - Okereke,Olivia I, AU - Grodstein,Francine, AU - Willett,Walter C, Y1 - 2018/11/21/ PY - 2018/02/05/received PY - 2018/09/06/accepted PY - 2018/11/23/pubmed PY - 2019/10/15/medline PY - 2018/11/23/entrez SP - e63 EP - e75 JF - Neurology JO - Neurology VL - 92 IS - 1 N2 - OBJECTIVE: To evaluate the prospective association of long-term intake of vegetables and fruits with late-life subjective cognitive function (SCF). METHODS: Among 27,842 men with a mean age of 51 years in 1986, we used multinomial logistic regression to examine the relation of vegetable and fruit consumption to future SCF. Average dietary intake was calculated from 5 repeated food frequency questionnaires collected every 4 years until 2002. SCF score was assessed twice (2008 and 2012) using a 6-item questionnaire; validity was supported by strong associations with APO ε4 genotype. We categorized the average of the 2 scores as good, moderate, and poor SCF. RESULTS: Higher intakes of total vegetables, total fruits, and fruit juice were each significantly associated with lower odds of moderate or poor SCF after controlling for major nondietary factors and total energy intake. The association with total fruit intake was weaker after further adjusting for major dietary factors. In this model, the multivariate odds ratios (95% confidence intervals) for vegetable intake (top vs bottom quintile) were 0.83 (0.76-0.92), p trend <0.001 for moderate SCF and 0.66 (0.55-0.80), p trend <0.001 for poor SCF. For orange juice, compared to <1 serving/mo of intake, daily consumption was associated with a substantially lower odds of poor SCF (0.53 [0.43-0.67], p trend <0.001). Higher consumption of vegetables and fruits 18 to 22 years before SCF assessment was associated with lower odds of poor SCF independent of more proximal intake. CONCLUSION: Our findings support a long-term beneficial role of vegetable, fruit, and orange juice consumption on SCF. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/30464030/full_citation DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓30 ↑47]

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