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Body size and obesity during adulthood, and risk of lympho-haematopoietic cancers: an update of the WCRF-AICR systematic review of published prospective studies.
Ann Oncol. 2019 Apr 01; 30(4):528-541.AO

Abstract

BACKGROUND

To summarise the evidence on the associations between body mass index (BMI) and BMI in early adulthood, height, waist circumference (WC) and waist-to-hip ratio (WHR), and risk of lympho-haematopoietic cancers.

METHOD

We conducted a meta-analysis of prospective studies and identified relevant studies published up to December 2017 by searching PubMed. A random-effects model was used to calculate dose-response summary relative risks (RRs).

RESULTS

Our findings showed BMI, and BMI in early adulthood (aged 18-21 years) is associated with the risk of Hodgkin's and non-Hodgkin's lymphoma (HL and NHL), diffuse large beta-cell lymphoma (DLBCL), Leukaemia including acute and chronic myeloid lymphoma (AML and CML), and chronic lymphocytic leukaemia (CLL) and multiple myeloma (MM). The summary RR per 5 kg/m2 increase in BMI were 1.12 [95% confidence interval (CI): 1.05-1.20] for HL, 1.05 (95% CI: 1.03-1.08) for NHL, 1.11 (95% CI: 1.05-1.16) for DLBCL, 1.06 (95% CI: 1.03-1.09) for ML, 1.09 (95% CI: 1.03-1.15) for leukaemia, 1.13 (95% CI: 1.04-1.24) for AML, 1.13 (95% CI: 1.05-1.22) for CML and 1.04 (95% CI: 1.00-1.09) for CLL, and were1.12 (95% CI: 1.05-1.19) for NHL, 1.22 (95% CI: 1.09-1.37) for DLBCL, and 1.19 (95% CI: 1.03-1.38) for FL for BMI in early adulthood analysis. Results on mortality showed a 15%, 16% and 17% increased risk of NHL, MM and leukaemia, respectively. Greater height increased the risk of NHL by 7%, DLBCL by 10%, FL by 9%, MM by 5% and Leukaemia by 7%. WHR was associated with increased risk of DLBCL by 12%. No association was found between higher WC and risk of MM.

CONCLUSION

Our results revealed that general adiposity in adulthood and early adulthood, and greater height may increase the risk of almost all types of lympho-haematopoietic cancers and this adds to a growing body of evidence linking body fatness to several types of cancers.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, Imperial College London, London. Electronic address: l.abar@imperial.ac.uk.

Department of Epidemiology and Biostatistics, Imperial College London, London; Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge.

Department of Epidemiology and Biostatistics, Imperial College London, London.

Department of Epidemiology and Biostatistics, Imperial College London, London.

Department of Epidemiology and Biostatistics, Imperial College London, London.

Department of Epidemiology and Biostatistics, Imperial College London, London.

Department of Epidemiology and Biostatistics, Imperial College London, London.

School of Medicine, University of Leeds, Leeds, UK.

Department of Epidemiology and Biostatistics, Imperial College London, London.

Department of Epidemiology and Biostatistics, Imperial College London, London.

MeSH

AdiposityBody Mass IndexBody SizeHumansLeukemiaLymphomaMultiple MyelomaObesityRisk AssessmentRisk Factors

Pub Type(s)

Journal Article

Meta-Analysis

Research Support, Non-U.S. Gov't

Systematic Review

Language

eng

PubMed ID

30753270

Citation

Abar, L, et al. "Body Size and Obesity During Adulthood, and Risk of Lympho-haematopoietic Cancers: an Update of the WCRF-AICR Systematic Review of Published Prospective Studies." Annals of Oncology : Official Journal of the European Society for Medical Oncology, vol. 30, no. 4, 2019, pp. 528-541.

Abar L, Sobiecki JG, Cariolou M, et al. Body size and obesity during adulthood, and risk of lympho-haematopoietic cancers: an update of the WCRF-AICR systematic review of published prospective studies. Ann Oncol. 2019;30(4):528-541.

Abar, L., Sobiecki, J. G., Cariolou, M., Nanu, N., Vieira, A. R., Stevens, C., Aune, D., Greenwood, D. C., Chan, D. S. M., & Norat, T. (2019). Body size and obesity during adulthood, and risk of lympho-haematopoietic cancers: an update of the WCRF-AICR systematic review of published prospective studies. Annals of Oncology : Official Journal of the European Society for Medical Oncology, 30(4), 528-541. https://doi.org/10.1093/annonc/mdz045

Abar L, et al. Body Size and Obesity During Adulthood, and Risk of Lympho-haematopoietic Cancers: an Update of the WCRF-AICR Systematic Review of Published Prospective Studies. Ann Oncol. 2019 04 1;30(4):528-541. PubMed PMID: 30753270.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Body size and obesity during adulthood, and risk of lympho-haematopoietic cancers: an update of the WCRF-AICR systematic review of published prospective studies. AU - Abar,L, AU - Sobiecki,J G, AU - Cariolou,M, AU - Nanu,N, AU - Vieira,A R, AU - Stevens,C, AU - Aune,D, AU - Greenwood,D C, AU - Chan,D S M, AU - Norat,T, PY - 2019/2/13/pubmed PY - 2020/4/21/medline PY - 2019/2/13/entrez KW - met analysis BMI leukaemia KW - met analysis BMI lymphoma KW - met analysis BMI myeloma KW - met analysis abdominal obesity lympho-haematopoietic cancer KW - met analysis general obesity lymphoma KW - met analysis height lympho-haematopoietic cancer SP - 528 EP - 541 JF - Annals of oncology : official journal of the European Society for Medical Oncology JO - Ann Oncol VL - 30 IS - 4 N2 - BACKGROUND: To summarise the evidence on the associations between body mass index (BMI) and BMI in early adulthood, height, waist circumference (WC) and waist-to-hip ratio (WHR), and risk of lympho-haematopoietic cancers. METHOD: We conducted a meta-analysis of prospective studies and identified relevant studies published up to December 2017 by searching PubMed. A random-effects model was used to calculate dose-response summary relative risks (RRs). RESULTS: Our findings showed BMI, and BMI in early adulthood (aged 18-21 years) is associated with the risk of Hodgkin's and non-Hodgkin's lymphoma (HL and NHL), diffuse large beta-cell lymphoma (DLBCL), Leukaemia including acute and chronic myeloid lymphoma (AML and CML), and chronic lymphocytic leukaemia (CLL) and multiple myeloma (MM). The summary RR per 5 kg/m2 increase in BMI were 1.12 [95% confidence interval (CI): 1.05-1.20] for HL, 1.05 (95% CI: 1.03-1.08) for NHL, 1.11 (95% CI: 1.05-1.16) for DLBCL, 1.06 (95% CI: 1.03-1.09) for ML, 1.09 (95% CI: 1.03-1.15) for leukaemia, 1.13 (95% CI: 1.04-1.24) for AML, 1.13 (95% CI: 1.05-1.22) for CML and 1.04 (95% CI: 1.00-1.09) for CLL, and were1.12 (95% CI: 1.05-1.19) for NHL, 1.22 (95% CI: 1.09-1.37) for DLBCL, and 1.19 (95% CI: 1.03-1.38) for FL for BMI in early adulthood analysis. Results on mortality showed a 15%, 16% and 17% increased risk of NHL, MM and leukaemia, respectively. Greater height increased the risk of NHL by 7%, DLBCL by 10%, FL by 9%, MM by 5% and Leukaemia by 7%. WHR was associated with increased risk of DLBCL by 12%. No association was found between higher WC and risk of MM. CONCLUSION: Our results revealed that general adiposity in adulthood and early adulthood, and greater height may increase the risk of almost all types of lympho-haematopoietic cancers and this adds to a growing body of evidence linking body fatness to several types of cancers. SN - 1569-8041 UR - https://www.unboundmedicine.com/medline/citation/30753270/full_citation DB - PRIME DP - Unbound Medicine ER -