TY - JOUR T1 - The Effectiveness of Vitamin E Treatment in Alzheimer's Disease. AU - Lloret,Ana, AU - Esteve,Daniel, AU - Monllor,Paloma, AU - Cervera-Ferri,Ana, AU - Lloret,Angeles, Y1 - 2019/02/18/ PY - 2019/01/07/received PY - 2019/01/31/revised PY - 2019/02/11/accepted PY - 2019/2/21/entrez PY - 2019/2/20/pubmed PY - 2019/6/1/medline KW - Alzheimer’s disease KW - antioxidants KW - brain health KW - non-respondents KW - respondents to vitamin E JF - International journal of molecular sciences JO - Int J Mol Sci VL - 20 IS - 4 N2 - Vitamin E was proposed as treatment for Alzheimer's disease many years ago. However, the effectiveness of the drug is not clear. Vitamin E is an antioxidant and neuroprotector and it has anti-inflammatory and hypocholesterolemic properties, driving to its importance for brain health. Moreover, the levels of vitamin E in Alzheimer's disease patients are lower than in non-demented controls. Thus, vitamin E could be a good candidate to have beneficial effects against Alzheimer's. However, evidence is consistent with a limited effectiveness of vitamin E in slowing progression of dementia; the information is mixed and inconclusive. The question is why does vitamin E fail to treat Alzheimer's disease? In this paper we review the studies with and without positive results in Alzheimer's disease and we discuss the reasons why vitamin E as treatment sometimes has positive results on cognition but at others, it does not. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/30781638/full_citation DB - PRIME DP - Unbound Medicine ER -