TY - JOUR T1 - A Plant-Based Meal Stimulates Incretin and Insulin Secretion More Than an Energy- and Macronutrient-Matched Standard Meal in Type 2 Diabetes: A Randomized Crossover Study. AU - Kahleova,Hana, AU - Tura,Andrea, AU - Klementova,Marta, AU - Thieme,Lenka, AU - Haluzik,Martin, AU - Pavlovicova,Renata, AU - Hill,Martin, AU - Pelikanova,Terezie, Y1 - 2019/02/26/ PY - 2019/02/04/received PY - 2019/02/20/revised PY - 2019/02/21/accepted PY - 2019/3/1/entrez PY - 2019/3/1/pubmed PY - 2019/5/11/medline KW - beta-cell function KW - incretins KW - insulin resistance KW - nutrition KW - plant-based KW - type 2 diabetes JF - Nutrients JO - Nutrients VL - 11 IS - 3 N2 - Diminished postprandial secretion of incretins and insulin represents one of the key pathophysiological mechanisms behind type 2 diabetes (T2D). We tested the effects of two energy- and macronutrient-matched meals: A standard meat (M-meal) and a vegan (V-meal) on postprandial incretin and insulin secretion in participants with T2D. A randomized crossover design was used in 20 participants with T2D. Plasma concentrations of glucose, insulin, C-peptide, glucagon-like peptide-1 (GLP-1), amylin, and gastric inhibitory peptide (GIP) were determined at 0, 30, 60, 120, and 180 min. Beta-cell function was assessed with a mathematical model, using C-peptide deconvolution. Repeated-measures ANOVA was used for statistical analysis. Postprandial plasma glucose responses were similar after both test meals (p = 0.64). An increase in the stimulated secretion of insulin (by 30.5%; 95% CI 21.2 to 40.7%; p < 0.001), C-peptide (by 7.1%; 95% CI 4.1 to 9.9%; p < 0.001), and amylin (by 15.7%; 95% CI 11.8 to 19.7%; p < 0.001) was observed following consumption of the V-meal. An increase in stimulated secretion of GLP-1 (by 19.2%; 95% CI 12.4 to 26.7%; p < 0.001) and a decrease in GIP (by -9.4%; 95% CI -17.3 to -0.7%; p = 0.02) were observed after the V-meal. Several parameters of beta-cell function increased after the V-meal, particularly insulin secretion at a fixed glucose value 5 mmol/L, rate sensitivity, and the potentiation factor. Our results showed an increase in postprandial incretin and insulin secretion, after consumption of a V-meal, suggesting a therapeutic potential of plant-based meals for improving beta-cell function in T2D. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/30813546/full_citation DB - PRIME DP - Unbound Medicine ER -