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Failure of lactose-restricted diets to prevent radiation-induced diarrhea in patients undergoing whole pelvis irradiation.
Int J Radiat Oncol Biol Phys 1986; 12(5):789-92IJ

Abstract

Sixty-four patients were randomized prior to pelvic radiotherapy into one of three dietary groups: the control group maintained a regular diet except that they drank at least 480 cc of milk daily; the lactose-restricted group was placed on a lactose-restricted diet; and the lactase group drank at least 480 cc of milk with lactase enzyme added to hydrolyze 90% of the lactose. The patients kept records of their stool frequency and the number of diphenoxylate tablets required to control their diarrhea during a 5 week course of standard whole pelvis irradiation. The data does not support the concept that one of the mechanisms of radiation-induced diarrhea associated with pelvic irradiation is a reduction the ability of the intestine to hydrolyze ingested lactose due to the effect of the radiation on the small intestine. There was not a significant difference in stool frequency or diphenoxylate usage among the dietary groups.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

3086261

Citation

Stryker, J A., and M Bartholomew. "Failure of Lactose-restricted Diets to Prevent Radiation-induced Diarrhea in Patients Undergoing Whole Pelvis Irradiation." International Journal of Radiation Oncology, Biology, Physics, vol. 12, no. 5, 1986, pp. 789-92.
Stryker JA, Bartholomew M. Failure of lactose-restricted diets to prevent radiation-induced diarrhea in patients undergoing whole pelvis irradiation. Int J Radiat Oncol Biol Phys. 1986;12(5):789-92.
Stryker, J. A., & Bartholomew, M. (1986). Failure of lactose-restricted diets to prevent radiation-induced diarrhea in patients undergoing whole pelvis irradiation. International Journal of Radiation Oncology, Biology, Physics, 12(5), pp. 789-92.
Stryker JA, Bartholomew M. Failure of Lactose-restricted Diets to Prevent Radiation-induced Diarrhea in Patients Undergoing Whole Pelvis Irradiation. Int J Radiat Oncol Biol Phys. 1986;12(5):789-92. PubMed PMID: 3086261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Failure of lactose-restricted diets to prevent radiation-induced diarrhea in patients undergoing whole pelvis irradiation. AU - Stryker,J A, AU - Bartholomew,M, PY - 1986/5/1/pubmed PY - 1986/5/1/medline PY - 1986/5/1/entrez SP - 789 EP - 92 JF - International journal of radiation oncology, biology, physics JO - Int. J. Radiat. Oncol. Biol. Phys. VL - 12 IS - 5 N2 - Sixty-four patients were randomized prior to pelvic radiotherapy into one of three dietary groups: the control group maintained a regular diet except that they drank at least 480 cc of milk daily; the lactose-restricted group was placed on a lactose-restricted diet; and the lactase group drank at least 480 cc of milk with lactase enzyme added to hydrolyze 90% of the lactose. The patients kept records of their stool frequency and the number of diphenoxylate tablets required to control their diarrhea during a 5 week course of standard whole pelvis irradiation. The data does not support the concept that one of the mechanisms of radiation-induced diarrhea associated with pelvic irradiation is a reduction the ability of the intestine to hydrolyze ingested lactose due to the effect of the radiation on the small intestine. There was not a significant difference in stool frequency or diphenoxylate usage among the dietary groups. SN - 0360-3016 UR - https://www.unboundmedicine.com/medline/citation/3086261/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/0360-3016(86)90037-4 DB - PRIME DP - Unbound Medicine ER -