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Failure of lactose-restricted diets to prevent radiation-induced diarrhea in patients undergoing whole pelvis irradiation.

Abstract

Sixty-four patients were randomized prior to pelvic radiotherapy into one of three dietary groups: the control group maintained a regular diet except that they drank at least 480 cc of milk daily; the lactose-restricted group was placed on a lactose-restricted diet; and the lactase group drank at least 480 cc of milk with lactase enzyme added to hydrolyze 90% of the lactose. The patients kept records of their stool frequency and the number of diphenoxylate tablets required to control their diarrhea during a 5 week course of standard whole pelvis irradiation. The data does not support the concept that one of the mechanisms of radiation-induced diarrhea associated with pelvic irradiation is a reduction the ability of the intestine to hydrolyze ingested lactose due to the effect of the radiation on the small intestine. There was not a significant difference in stool frequency or diphenoxylate usage among the dietary groups.

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    MeSH

    Animals
    Diarrhea
    Dietary Carbohydrates
    Diphenoxylate
    Female
    Humans
    Hydrolysis
    Lactose
    Lactose Intolerance
    Male
    Middle Aged
    Milk
    Pelvic Neoplasms
    Radiation Injuries
    Random Allocation
    beta-Galactosidase

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    3086261

    Citation

    Stryker, J A., and M Bartholomew. "Failure of Lactose-restricted Diets to Prevent Radiation-induced Diarrhea in Patients Undergoing Whole Pelvis Irradiation." International Journal of Radiation Oncology, Biology, Physics, vol. 12, no. 5, 1986, pp. 789-92.
    Stryker JA, Bartholomew M. Failure of lactose-restricted diets to prevent radiation-induced diarrhea in patients undergoing whole pelvis irradiation. Int J Radiat Oncol Biol Phys. 1986;12(5):789-92.
    Stryker, J. A., & Bartholomew, M. (1986). Failure of lactose-restricted diets to prevent radiation-induced diarrhea in patients undergoing whole pelvis irradiation. International Journal of Radiation Oncology, Biology, Physics, 12(5), pp. 789-92.
    Stryker JA, Bartholomew M. Failure of Lactose-restricted Diets to Prevent Radiation-induced Diarrhea in Patients Undergoing Whole Pelvis Irradiation. Int J Radiat Oncol Biol Phys. 1986;12(5):789-92. PubMed PMID: 3086261.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Failure of lactose-restricted diets to prevent radiation-induced diarrhea in patients undergoing whole pelvis irradiation. AU - Stryker,J A, AU - Bartholomew,M, PY - 1986/5/1/pubmed PY - 1986/5/1/medline PY - 1986/5/1/entrez SP - 789 EP - 92 JF - International journal of radiation oncology, biology, physics JO - Int. J. Radiat. Oncol. Biol. Phys. VL - 12 IS - 5 N2 - Sixty-four patients were randomized prior to pelvic radiotherapy into one of three dietary groups: the control group maintained a regular diet except that they drank at least 480 cc of milk daily; the lactose-restricted group was placed on a lactose-restricted diet; and the lactase group drank at least 480 cc of milk with lactase enzyme added to hydrolyze 90% of the lactose. The patients kept records of their stool frequency and the number of diphenoxylate tablets required to control their diarrhea during a 5 week course of standard whole pelvis irradiation. The data does not support the concept that one of the mechanisms of radiation-induced diarrhea associated with pelvic irradiation is a reduction the ability of the intestine to hydrolyze ingested lactose due to the effect of the radiation on the small intestine. There was not a significant difference in stool frequency or diphenoxylate usage among the dietary groups. SN - 0360-3016 UR - https://www.unboundmedicine.com/medline/citation/3086261/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/0360-3016(86)90037-4 DB - PRIME DP - Unbound Medicine ER -