The Impact of Obesity on Breast Cancer Diagnosis and Treatment.
Curr Oncol Rep. 2019 Mar 27; 21(5):41.CO

Abstract

PURPOSE OF REVIEW

Obesity is a recognized risk factor for the development of breast cancer and recurrence even when patients are treated appropriately. We reviewed the literature that addresses the impact of obesity on diagnosis and the individual therapeutic interventions, and present a summary of the findings.

RECENT FINDINGS

Compared to non-obese women with breast cancer, obese women with breast cancer have a worse disease-free and overall survival despite appropriate local and systemic therapies. In brief, obese breast cancer patients experience more complications related to surgery, radiation, and chemotherapy. Further, obese patients are at increased risk for local recurrence compared to normal-weight women. Similarly, systemic chemotherapy is less effective, even when dosed appropriately on the basis of actual weight. Overall, endocrine therapy is less effective in obese women, and there is a suggestion that aromatase inhibitors may be selectively less effective than tamoxifen. Obese women are less likely to undergo breast reconstruction than normal-weight women, and those who do have surgery experience more surgical complications. The efficacy of cancer treatments is significantly lower in obese breast cancer survivors, posing greater challenges in patient care and disease management in this patient population. Further investigations are warranted to assess the effects on treatment outcomes and optimize therapeutic mechanisms in order to successfully target breast cancer associated with obesity.

Links

PMC Free PDF

Authors+Show Affiliations

Lee K

Division of Biokinesiology and Physical Therapy, University of Southern California (USC), 1540 E. Alcazar Street, CHP 155, Los Angeles, CA, 90033, USA.

Kruper L

Department of Surgical Oncology, City of Hope Comprehensive Cancer Center, 1500 E Duarte Rd, Duarte, CA, 91010, USA.

Dieli-Conwright CM

Division of Biokinesiology and Physical Therapy, University of Southern California (USC), 1540 E. Alcazar Street, CHP 155, Los Angeles, CA, 90033, USA.

Mortimer JE

Department of Medical Oncology & Experimental Therapeutics, City of Hope Comprehensive Cancer, 1500 E Duarte Rd, Duarte, CA, 91010, USA. jmortimer@coh.org. Department of Medical Oncology & Experimental Therapeutics, City of Hope National Medical Center, 1500 E Duarte Rd, Duarte, CA, 91010, USA. jmortimer@coh.org.

MeSH

Antineoplastic Agents, HormonalBreast NeoplasmsEarly Detection of CancerFemaleHumansObesityPhysician-Patient RelationsPostoperative ComplicationsRadiotherapyTreatment Outcome

Pub Type(s)

Journal Article

Review

Language

eng

PubMed ID

30919143

Citation

Lee, Kyuwan, et al. "The Impact of Obesity On Breast Cancer Diagnosis and Treatment." Current Oncology Reports, vol. 21, no. 5, 2019, p. 41.

Lee K, Kruper L, Dieli-Conwright CM, et al. The Impact of Obesity on Breast Cancer Diagnosis and Treatment. Curr Oncol Rep. 2019;21(5):41.

Lee, K., Kruper, L., Dieli-Conwright, C. M., & Mortimer, J. E. (2019). The Impact of Obesity on Breast Cancer Diagnosis and Treatment. Current Oncology Reports, 21(5), 41. https://doi.org/10.1007/s11912-019-0787-1

Lee K, et al. The Impact of Obesity On Breast Cancer Diagnosis and Treatment. Curr Oncol Rep. 2019 03 27;21(5):41. PubMed PMID: 30919143.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - The Impact of Obesity on Breast Cancer Diagnosis and Treatment. AU - Lee,Kyuwan, AU - Kruper,Laura, AU - Dieli-Conwright,Christina M, AU - Mortimer,Joanne E, Y1 - 2019/03/27/ PY - 2019/3/29/entrez PY - 2019/3/29/pubmed PY - 2020/8/1/medline KW - Breast cancer KW - Clinical outcomes KW - Diagnosis KW - Obesity KW - Treatment SP - 41 EP - 41 JF - Current oncology reports JO - Curr Oncol Rep VL - 21 IS - 5 N2 - PURPOSE OF REVIEW: Obesity is a recognized risk factor for the development of breast cancer and recurrence even when patients are treated appropriately. We reviewed the literature that addresses the impact of obesity on diagnosis and the individual therapeutic interventions, and present a summary of the findings. RECENT FINDINGS: Compared to non-obese women with breast cancer, obese women with breast cancer have a worse disease-free and overall survival despite appropriate local and systemic therapies. In brief, obese breast cancer patients experience more complications related to surgery, radiation, and chemotherapy. Further, obese patients are at increased risk for local recurrence compared to normal-weight women. Similarly, systemic chemotherapy is less effective, even when dosed appropriately on the basis of actual weight. Overall, endocrine therapy is less effective in obese women, and there is a suggestion that aromatase inhibitors may be selectively less effective than tamoxifen. Obese women are less likely to undergo breast reconstruction than normal-weight women, and those who do have surgery experience more surgical complications. The efficacy of cancer treatments is significantly lower in obese breast cancer survivors, posing greater challenges in patient care and disease management in this patient population. Further investigations are warranted to assess the effects on treatment outcomes and optimize therapeutic mechanisms in order to successfully target breast cancer associated with obesity. SN - 1534-6269 UR - https://www.unboundmedicine.com/medline/citation/30919143/full_citation DB - PRIME DP - Unbound Medicine ER -

Tags

The Impact of Obesity on Breast Cancer Diagnosis and Treatment.Curr Oncol Rep. 2019 Mar 27; 21(5):41.CO