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Protein redistribution diet restores motor function in patients with dopa-resistant "off" periods.

Abstract

Sixteen parkinsonians with acquired drug-resistant "off" periods without dyskinesia were placed on a diet in which virtually all protein was concentrated in the evening meal. Restoration of sensitivity to levodopa resulted in 88%. Ten patients (62%) have continued to comply with the diet for 7 months (mean). Two patients were studied in detail. Immobility correlated with elevated plasma levels of large neutral amino acids (LNAA), normality with low LNAA.

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  • Authors+Show Affiliations

    ,

    Yale University School of Medicine, Department of Neurology, New Haven, CT.

    Source

    Neurology 38:3 1988 Mar pg 481-3

    MeSH

    Amino Acids
    Dietary Proteins
    Dihydroxyphenylalanine
    Drug Resistance
    Follow-Up Studies
    Humans
    Motor Activity
    Osmolar Concentration
    Parkinson Disease

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    3126411

    Citation

    TY - JOUR T1 - Protein redistribution diet restores motor function in patients with dopa-resistant "off" periods. AU - Pincus,J H, AU - Barry,K, PY - 1988/3/1/pubmed PY - 1988/3/1/medline PY - 1988/3/1/entrez SP - 481 EP - 3 JF - Neurology JO - Neurology VL - 38 IS - 3 N2 - Sixteen parkinsonians with acquired drug-resistant "off" periods without dyskinesia were placed on a diet in which virtually all protein was concentrated in the evening meal. Restoration of sensitivity to levodopa resulted in 88%. Ten patients (62%) have continued to comply with the diet for 7 months (mean). Two patients were studied in detail. Immobility correlated with elevated plasma levels of large neutral amino acids (LNAA), normality with low LNAA. SN - 0028-3878 UR - https://www.unboundmedicine.com/medline/citation/3126411/full_citation L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=3126411.ui ER -