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Low-Fat Dietary Pattern and Cancer Mortality in the Women's Health Initiative (WHI) Randomized Controlled Trial.
JNCI Cancer Spectr. 2018 Oct; 2(4):pky065.JC

Abstract

BACKGROUND

In the Women's Health Initiative Dietary Modification trial, a low-fat dietary pattern reduced deaths after breast cancer. Mortality from other cancer sites has not been reported.

METHODS

A low-fat dietary pattern influence on deaths from and after site-specific cancers was examined during 8.5 years (median) of dietary intervention and cumulatively during 17.7 years (median) of follow-up. A total 48 835 postmenopausal women, ages 50-79 years, were randomly assigned from 1993 to 1998 at 40 US clinical centers to dietary intervention (40%, n = 19 541 or a usual diet comparison group (60%, n = 29 294). Dietary intervention influence on mortality from protocol-specified cancers (breast, colon and rectum, endometrium and ovary), individually and as a composite, represented the primary analyses.

RESULTS

During the dietary intervention period, a reduction in deaths after breast cancer (HR = 0.65 95% CI = 0.45 to 0.94, P = .02) was the only statistically significant cancer mortality finding. During intervention, the HRs for deaths after the protocol-specified cancer composite were 0.90 (95% CI = 0.73 to 1.10) and 0.95 (95% CI = 0.85 to 1.06) for deaths after all cancers. During 17.7 years of follow-up with 3867 deaths after all cancers, reduction in deaths after breast cancer continued in the dietary intervention group (HR = 0.85, 95% CI = 0.74 to 0.99, P = .03). However, no dietary intervention influence on deaths from or after any other cancer or cancer composite was seen.

CONCLUSIONS

A low-fat dietary pattern reduced deaths after breast cancer. No reduction in mortality from or after any other cancer or cancer composite was seen.

Links

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Authors+Show Affiliations

Chlebowski RT
Los Angeles Biomedical Research Institute, Torrance, CA.
Anderson GL
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.
Manson JE
Harvard Medical School, Brigham and Women's Hospital, Boston, MA.
Prentice RL
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.
Aragaki AK
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.
Snetselaar L
University of Iowa, Iowa City/Davenport, IA.
Beresford SAA
Department of Epidemiology, University of Washington, Seattle, WA.
Kuller LH
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA.
Johnson K
Department of Preventive Medicine, University of Tennessee, Memphis, TN.
Lane D
Preventive Medicine, Stony Brook University, Stony Brook, NY.
Luo J
School of Public Health, University of Indiana, Bloomington, IN.
Rohan TE
Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY.
Jiao L
Department of Medicine, Baylor College of Medicine, Houston, TX.
Barac A
MedStar Health Research Institute and Georgetown/Howard Universities Center for Clinical and Translational Sciences, Washington, DC.
Womack C
Methodist Healthcare, Memphis, TN.
Coday M
Department of Preventive Medicine, University of Tennessee, Memphis, TN.
Datta M
School of Public Health, University of Purdue, West Lafayette, IN.
Thomson CA
Mel and Enid Zuckerman College of Public Health, University of Arizona Cancer Center, Tucson, AZ.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31360880

Citation

Chlebowski, Rowan T., et al. "Low-Fat Dietary Pattern and Cancer Mortality in the Women's Health Initiative (WHI) Randomized Controlled Trial." JNCI Cancer Spectrum, vol. 2, no. 4, 2018, pp. pky065.
Chlebowski RT, Anderson GL, Manson JE, et al. Low-Fat Dietary Pattern and Cancer Mortality in the Women's Health Initiative (WHI) Randomized Controlled Trial. JNCI Cancer Spectr. 2018;2(4):pky065.
Chlebowski, R. T., Anderson, G. L., Manson, J. E., Prentice, R. L., Aragaki, A. K., Snetselaar, L., Beresford, S. A. A., Kuller, L. H., Johnson, K., Lane, D., Luo, J., Rohan, T. E., Jiao, L., Barac, A., Womack, C., Coday, M., Datta, M., & Thomson, C. A. (2018). Low-Fat Dietary Pattern and Cancer Mortality in the Women's Health Initiative (WHI) Randomized Controlled Trial. JNCI Cancer Spectrum, 2(4), pky065. https://doi.org/10.1093/jncics/pky065
Chlebowski RT, et al. Low-Fat Dietary Pattern and Cancer Mortality in the Women's Health Initiative (WHI) Randomized Controlled Trial. JNCI Cancer Spectr. 2018;2(4):pky065. PubMed PMID: 31360880.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low-Fat Dietary Pattern and Cancer Mortality in the Women's Health Initiative (WHI) Randomized Controlled Trial. AU - Chlebowski,Rowan T, AU - Anderson,Garnet L, AU - Manson,JoAnn E, AU - Prentice,Ross L, AU - Aragaki,Aaron K, AU - Snetselaar,Linda, AU - Beresford,Shirley A A, AU - Kuller,Lewis H, AU - Johnson,Karen, AU - Lane,Dorothy, AU - Luo,Juhua, AU - Rohan,Thomas E, AU - Jiao,Li, AU - Barac,Ana, AU - Womack,Catherine, AU - Coday,Mace, AU - Datta,Mridul, AU - Thomson,Cynthia A, Y1 - 2019/01/07/ PY - 2018/05/10/received PY - 2018/07/19/revised PY - 2018/10/03/accepted PY - 2019/7/31/entrez PY - 2019/7/31/pubmed PY - 2019/7/31/medline SP - pky065 EP - pky065 JF - JNCI cancer spectrum JO - JNCI Cancer Spectr VL - 2 IS - 4 N2 - BACKGROUND: In the Women's Health Initiative Dietary Modification trial, a low-fat dietary pattern reduced deaths after breast cancer. Mortality from other cancer sites has not been reported. METHODS: A low-fat dietary pattern influence on deaths from and after site-specific cancers was examined during 8.5 years (median) of dietary intervention and cumulatively during 17.7 years (median) of follow-up. A total 48 835 postmenopausal women, ages 50-79 years, were randomly assigned from 1993 to 1998 at 40 US clinical centers to dietary intervention (40%, n = 19 541 or a usual diet comparison group (60%, n = 29 294). Dietary intervention influence on mortality from protocol-specified cancers (breast, colon and rectum, endometrium and ovary), individually and as a composite, represented the primary analyses. RESULTS: During the dietary intervention period, a reduction in deaths after breast cancer (HR = 0.65 95% CI = 0.45 to 0.94, P = .02) was the only statistically significant cancer mortality finding. During intervention, the HRs for deaths after the protocol-specified cancer composite were 0.90 (95% CI = 0.73 to 1.10) and 0.95 (95% CI = 0.85 to 1.06) for deaths after all cancers. During 17.7 years of follow-up with 3867 deaths after all cancers, reduction in deaths after breast cancer continued in the dietary intervention group (HR = 0.85, 95% CI = 0.74 to 0.99, P = .03). However, no dietary intervention influence on deaths from or after any other cancer or cancer composite was seen. CONCLUSIONS: A low-fat dietary pattern reduced deaths after breast cancer. No reduction in mortality from or after any other cancer or cancer composite was seen. SN - 2515-5091 UR - https://www.unboundmedicine.com/medline/citation/31360880/full_citation DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓14 ↑37]

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