TY - JOUR T1 - Stability of Ceftazidime Pentahydrate Investigated by Thermal Analysis Techniques. AU - Alves de Santana,Maria Silmara, AU - Santiago de Oliveira,Yara, AU - de Castro Fonseca,Jéssica, AU - Ferreira,Wellington Castro, AU - Neto,Vasco Stascxak, AU - Ayala,Alejandro Pedro, Y1 - 2019/11/27/ PY - 2019/07/09/received PY - 2019/11/05/revised PY - 2019/11/19/accepted PY - 2019/12/1/pubmed PY - 2021/6/22/medline PY - 2019/12/1/entrez KW - ceftazidime pentahydrate KW - cephalosporin KW - stability KW - thermal analysis SP - 1324 EP - 1329 JF - Journal of pharmaceutical sciences JO - J Pharm Sci VL - 109 IS - 3 N2 - Cephalosporins are among the most frequently used broad-spectrum antimicrobial agents. Ceftazidime is a semisynthetic β-lactam antibiotic for parenteral administration widely used in the clinical practice, which has been categorized as a third-generation cephalosporin antibiotic. This drug crystallizes as a pentahydrate and, as all cephalosporins, it is unstable and subject to hydrolytic degradation. Taking this into account, this study investigates the stability under 2 different conditions (high temperature and exposition to vacuum) by using various techniques, as thermal analysis, Raman spectroscopy, and X-ray powder diffraction supported by multivariate curve resolution. It was proved that ceftazidime pentahydrate is unstable under the studied variables, exhibiting several transformation processes, which were discussed in terms of the crystalline structure. SN - 1520-6017 UR - https://www.unboundmedicine.com/medline/citation/31785240 DB - PRIME DP - Unbound Medicine ER -