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Multiple sclerosis: the lipid relationship.

Abstract

Between 1949 and 1984, 150 multiple sclerosis patients consumed low-fat diets. Fats, oils, and protein intakes; disability; and deaths were determined. On daily fat consumption of less than 20.1 g (average 17 g), 31% died and deterioration was slight. Daily intakes of greater than 20 g (average of either 25 or 41 g) were attended by serious disability and deaths of 79% and 81%, respectively. Oil intakes bore an indirect relationship to fat consumption. Treatment early and before severe disability developed improved prognosis, and females tended to do better than males. High sensitivity to fats suggests they are involved in the genesis of multiple sclerosis.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Neurology, Oregon Health Sciences University, Portland 97201.

    Source

    MeSH

    Adult
    Dietary Fats
    Female
    Humans
    Male
    Multiple Sclerosis
    Oils
    Prognosis
    Sex Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    3202088

    Citation

    Swank, R L., and A Grimsgaard. "Multiple Sclerosis: the Lipid Relationship." The American Journal of Clinical Nutrition, vol. 48, no. 6, 1988, pp. 1387-93.
    Swank RL, Grimsgaard A. Multiple sclerosis: the lipid relationship. Am J Clin Nutr. 1988;48(6):1387-93.
    Swank, R. L., & Grimsgaard, A. (1988). Multiple sclerosis: the lipid relationship. The American Journal of Clinical Nutrition, 48(6), pp. 1387-93.
    Swank RL, Grimsgaard A. Multiple Sclerosis: the Lipid Relationship. Am J Clin Nutr. 1988;48(6):1387-93. PubMed PMID: 3202088.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Multiple sclerosis: the lipid relationship. AU - Swank,R L, AU - Grimsgaard,A, PY - 1988/12/1/pubmed PY - 1988/12/1/medline PY - 1988/12/1/entrez SP - 1387 EP - 93 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 48 IS - 6 N2 - Between 1949 and 1984, 150 multiple sclerosis patients consumed low-fat diets. Fats, oils, and protein intakes; disability; and deaths were determined. On daily fat consumption of less than 20.1 g (average 17 g), 31% died and deterioration was slight. Daily intakes of greater than 20 g (average of either 25 or 41 g) were attended by serious disability and deaths of 79% and 81%, respectively. Oil intakes bore an indirect relationship to fat consumption. Treatment early and before severe disability developed improved prognosis, and females tended to do better than males. High sensitivity to fats suggests they are involved in the genesis of multiple sclerosis. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/3202088/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/48.6.1387 DB - PRIME DP - Unbound Medicine ER -