TY - JOUR T1 - Functional Connectomic Approach to Studying Selank and Semax Effects. AU - Panikratova,Ya R, AU - Lebedeva,I S, AU - Sokolov,O Yu, AU - Rumshiskaya,A D, AU - Kupriyanov,D A, AU - Kost,N V, AU - Myasoedov,N F, Y1 - 2020/04/27/ PY - 2019/07/22/received PY - 2019/07/22/accepted PY - 2019/07/22/revised PY - 2020/4/29/entrez PY - 2020/4/29/pubmed PY - 2021/2/26/medline KW - Selank KW - Semax KW - functional connectivity analysis KW - resting-state fMRI SP - 9 EP - 11 JF - Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections JO - Dokl Biol Sci VL - 490 IS - 1 N2 - The present study was aimed at the assessment of effects of anxiolytic Selank and nootropic Semax on the whole-brain resting-state functional connectivity (FC) of each of the predefined regions of interest (ROIs) in 52 healthy participants. The ROIs included amygdala (one of the key regions for the regulation of anxiety) and dorsolateral prefrontal cortex (DLPFC; the key region for executive functions, including working memory) in the right and left hemisphere. Resting-state fMRI was carried out three times, namely before, after 5 and 20 min of the injection of either Semax, or Selank, or placebo. Between-group alongwith between-condition differences were revealed in FC between the right amygdala and a region in fusiform, inferior and middle temporal as well as parahippocampal gyri in the right hemisphere. Post hoc analysis allowed us to define both general and specific effects of Selank and Semax on FC between the right amygdala and the right temporal cortex for the first time. SN - 1608-3105 UR - https://www.unboundmedicine.com/medline/citation/32342318/Functional_Connectomic_Approach_to_Studying_Selank_and_Semax_Effects DB - PRIME DP - Unbound Medicine ER -