TY - JOUR T1 - Current Understanding of an Emerging Role of HLA-DRB1 Gene in Rheumatoid Arthritis-From Research to Clinical Practice. AU - Wysocki,Tomasz, AU - Olesińska,Marzena, AU - Paradowska-Gorycka,Agnieszka, Y1 - 2020/05/02/ PY - 2020/03/27/received PY - 2020/04/28/revised PY - 2020/04/30/accepted PY - 2020/5/7/entrez PY - 2020/5/7/pubmed PY - 2021/2/24/medline KW - HLA-DRB1 KW - polymorphisms KW - rheumatoid arthritis JF - Cells JO - Cells VL - 9 IS - 5 N2 - Rheumatoid arthritis (RA) is an autoimmune disease with an unclear pathogenic mechanism. However, it has been proven that the key underlying risk factor is a genetic predisposition. Association studies of the HLA-DRB1 gene clearly indicate its importance in RA morbidity. This review presents the current state of knowledge on the impact of HLA-DRB1 gene, functioning both as a component of the patient's genome and as an environmental risk factor. The impact of known HLA-DRB1 risk variants on the specific structure of the polymorphic HLA-DR molecule, and epitope binding affinity, is presented. The issues of the potential influence of HLA-DRB1 on the occurrence of non-articular disease manifestations and response to treatment are also discussed. A deeper understanding of the role of the HLA-DRB1 gene is essential to explore the complex nature of RA, which is a result of multiple contributing factors, including genetic, epigenetic and environmental factors. It also creates new opportunities to develop modern and personalized forms of therapy. SN - 2073-4409 UR - https://www.unboundmedicine.com/medline/citation/32370106/full_citation DB - PRIME DP - Unbound Medicine ER -