ALWAYS ICSI? A SWOT analysis.
J Assist Reprod Genet. 2020 Sep; 37(9):2081-2092.JA

Abstract

PURPOSE

Intracytroplasmatic sperm injection (ICSI) is a common procedure used to improve reproductive results, even among couples without male factor infertility. However, the evidence available is still uncertain on the possible advantages and deficiencies that this procedure may have in patients with no formal indication for ICSI.

METHODS

A SWOT (strengths, weaknesses, opportunities, threats) analysis examines the possible advantages and deficiencies of performing ICSI in these patients with no formal indication.

RESULTS

The evidence suggests that ICSI is not justified for non-male factor infertile couples requiring in vitro conception. One of the major strengths associated to the procedure is the virtual elimination of cases further complicated by total fertilization failure and a combination between IVF and ICSI on sibling oocytes has been advised in the literature. Greater technical difficulties, higher costs and performing an unnecessary invasive technique in some cases represent some of the weaknesses of the procedure, and questions regarding safety issues should not be ruled out.

CONCLUSION

Despite the widespread use of ICSI in patients without a formal diagnosis of male factor infertility, evidence demonstrating its effectiveness in this population is still lacking. Additional large and well-designed randomized controlled trials are needed to clarify definitive indications for ICSI in non-male factor infertility.

Links

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Authors+Show Affiliations

Bosch E

IVI RMA Valencia, Plaza de la Policía Local, 3, 46015, Valencia, Spain. Ernesto.Bosch@ivirma.com.

Espinós JJ

Fertty, Ausiàs March 25, 08010, Barcelona, Spain. Universidad Autónoma de Barcelona, Campus de la UAB, Plaza Cívica, s/n, 08193, Bellaterra (Barcelona), Spain.

Fabregues F

Institut Clinic Gynecology, Obstetrics and Neonatology (ICGON), Hospital Clinic, C/Villarroel 160, 08036, Barcelona, Spain.

Fontes J

Hospital Universitario Virgen de las Nieves, Avd Fuerzas Armadas s/n, 18014, Granada, Spain.

García-Velasco J

IVI RMA Madrid, Avda. del Talgo 68, 28023, Madrid, Spain.

Llácer J

Instituto Bernabeu Alicante, Av. Albufereta, 31, 03540, Alacant (Alicante), Spain.

Requena A

IVI RMA Madrid, Avda. del Talgo 68, 28023, Madrid, Spain.

Checa MA

Hospital del Mar-Parc de Salut Mar, Paseo Maritimo 25-29, 08005, Barcelona, Spain.

Bellver J

IVI RMA Valencia, Plaza de la Policía Local, 3, 46015, Valencia, Spain. Departamento de Pediatría, Obstetricia y Ginecología. Facultad de Medicina, Universidad de Valencia, Valencia, Spain.

Spanish Infertility SWOT Group (SISG)

No affiliation info available

MeSH

AdultEmbryo TransferFemaleFertilization in VitroHumansInfertility, MaleMaleOocytesPregnancyPregnancy RateSemenSperm Injections, IntracytoplasmicSpermatozoa

Pub Type(s)

Journal Article

Review

Language

eng

PubMed ID

32578032

Citation

Bosch, E, et al. "ALWAYS ICSI? a SWOT Analysis." Journal of Assisted Reproduction and Genetics, vol. 37, no. 9, 2020, pp. 2081-2092.

Bosch E, Espinós JJ, Fabregues F, et al. ALWAYS ICSI? A SWOT analysis. J Assist Reprod Genet. 2020;37(9):2081-2092.

Bosch, E., Espinós, J. J., Fabregues, F., Fontes, J., García-Velasco, J., Llácer, J., Requena, A., Checa, M. A., & Bellver, J. (2020). ALWAYS ICSI? A SWOT analysis. Journal of Assisted Reproduction and Genetics, 37(9), 2081-2092. https://doi.org/10.1007/s10815-020-01836-0

Bosch E, et al. ALWAYS ICSI? a SWOT Analysis. J Assist Reprod Genet. 2020;37(9):2081-2092. PubMed PMID: 32578032.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - ALWAYS ICSI? A SWOT analysis. AU - Bosch,E, AU - Espinós,J J, AU - Fabregues,F, AU - Fontes,J, AU - García-Velasco,J, AU - Llácer,J, AU - Requena,A, AU - Checa,M A, AU - Bellver,J, AU - ,, Y1 - 2020/06/24/ PY - 2020/02/25/received PY - 2020/05/17/accepted PY - 2020/6/25/pubmed PY - 2021/5/28/medline PY - 2020/6/25/entrez KW - Assisted reproduction KW - In vitro fertilization (IVF) KW - Infertility KW - Intracytoplasmic sperm injection (ICSI) KW - Pregnancy KW - Severe non-male factor SP - 2081 EP - 2092 JF - Journal of assisted reproduction and genetics JO - J Assist Reprod Genet VL - 37 IS - 9 N2 - PURPOSE: Intracytroplasmatic sperm injection (ICSI) is a common procedure used to improve reproductive results, even among couples without male factor infertility. However, the evidence available is still uncertain on the possible advantages and deficiencies that this procedure may have in patients with no formal indication for ICSI. METHODS: A SWOT (strengths, weaknesses, opportunities, threats) analysis examines the possible advantages and deficiencies of performing ICSI in these patients with no formal indication. RESULTS: The evidence suggests that ICSI is not justified for non-male factor infertile couples requiring in vitro conception. One of the major strengths associated to the procedure is the virtual elimination of cases further complicated by total fertilization failure and a combination between IVF and ICSI on sibling oocytes has been advised in the literature. Greater technical difficulties, higher costs and performing an unnecessary invasive technique in some cases represent some of the weaknesses of the procedure, and questions regarding safety issues should not be ruled out. CONCLUSION: Despite the widespread use of ICSI in patients without a formal diagnosis of male factor infertility, evidence demonstrating its effectiveness in this population is still lacking. Additional large and well-designed randomized controlled trials are needed to clarify definitive indications for ICSI in non-male factor infertility. SN - 1573-7330 UR - https://www.unboundmedicine.com/medline/citation/32578032/ALWAYS_ICSI_A_SWOT_analysis. DB - PRIME DP - Unbound Medicine ER -

Tags

ALWAYS ICSI? A SWOT analysis.J Assist Reprod Genet. 2020 Sep; 37(9):2081-2092.JA