TY - JOUR T1 - Emerging Pandemic Diseases: How We Got to COVID-19. AU - Morens,David M, AU - Fauci,Anthony S, Y1 - 2020/08/15/ PY - 2020/07/07/received PY - 2020/08/07/revised PY - 2020/08/12/accepted PY - 2020/8/28/pubmed PY - 2020/9/18/medline PY - 2020/8/27/entrez KW - COVID-19 KW - One Health KW - disease ecology KW - epidemic KW - epizootic KW - infection KW - medical history KW - pandemic KW - virology KW - zoonosis SP - 1077 EP - 1092 JF - Cell JO - Cell VL - 182 IS - 5 N2 - Infectious diseases prevalent in humans and animals are caused by pathogens that once emerged from other animal hosts. In addition to these established infections, new infectious diseases periodically emerge. In extreme cases they may cause pandemics such as COVID-19; in other cases, dead-end infections or smaller epidemics result. Established diseases may also re-emerge, for example by extending geographically or by becoming more transmissible or more pathogenic. Disease emergence reflects dynamic balances and imbalances, within complex globally distributed ecosystems comprising humans, animals, pathogens, and the environment. Understanding these variables is a necessary step in controlling future devastating disease emergences. SN - 1097-4172 UR - https://www.unboundmedicine.com/medline/citation/32846157/Emerging_Pandemic_Diseases:_How_We_Got_to_COVID-19. DB - PRIME DP - Unbound Medicine ER -