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Dietary Patterns, Carbohydrates, and Age-Related Eye Diseases.
Nutrients. 2020 Sep 18; 12(9)N

Abstract

Over a third of older adults in the U.S. experience significant vision loss, which decreases independence and is a biomarker of decreased health span. As the global aging population is expanding, it is imperative to uncover strategies to increase health span and reduce the economic burden of this age-related disease. While there are some treatments available for age-related vision loss, such as surgical removal of cataracts, many causes of vision loss, such as dry age-related macular degeneration (AMD), remain poorly understood and no treatments are currently available. Therefore, it is necessary to better understand the factors that contribute to disease progression for age-related vision loss and to uncover methods for disease prevention. One such factor is the effect of diet on ocular diseases. There are many reviews regarding micronutrients and their effect on eye health. Here, we discuss the impact of dietary patterns on the incidence and progression of age-related eye diseases, namely AMD, cataracts, diabetic retinopathy, and glaucoma. Then, we focus on the specific role of dietary carbohydrates, first by outlining the physiological effects of carbohydrates on the body and then how these changes translate into eye and age-related ocular diseases. Finally, we discuss future directions of nutrition research as it relates to aging and vision loss, with a discussion of caloric restriction, intermittent fasting, drug interventions, and emerging randomized clinical trials. This is a rich field with the capacity to improve life quality for millions of people so they may live with clear vision for longer and avoid the high cost of vision-saving surgeries.

Links

Authors+Show Affiliations

JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.

JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA. Friedman School of Nutrition and Science Policy, Tufts University, Boston, MA 02111, USA.

JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.

JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.

JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.

JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.

JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.

JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA. Friedman School of Nutrition and Science Policy, Tufts University, Boston, MA 02111, USA. Department of Ophthalmology, Tufts University School of Medicine, Boston, MA 02111, USA.

JM-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA. Friedman School of Nutrition and Science Policy, Tufts University, Boston, MA 02111, USA. Department of Ophthalmology, Tufts University School of Medicine, Boston, MA 02111, USA.

MeSH

DietDietary CarbohydratesFeeding BehaviorHumansMacular DegenerationRisk Factors

Pub Type(s)

Journal Article

Review

Language

eng

PubMed ID

32962100

Citation

Francisco, Sarah G., et al. "Dietary Patterns, Carbohydrates, and Age-Related Eye Diseases." Nutrients, vol. 12, no. 9, 2020.

Francisco SG, Smith KM, Aragonès G, et al. Dietary Patterns, Carbohydrates, and Age-Related Eye Diseases. Nutrients. 2020;12(9).

Francisco, S. G., Smith, K. M., Aragonès, G., Whitcomb, E. A., Weinberg, J., Wang, X., Bejarano, E., Taylor, A., & Rowan, S. (2020). Dietary Patterns, Carbohydrates, and Age-Related Eye Diseases. Nutrients, 12(9). https://doi.org/10.3390/nu12092862

Francisco SG, et al. Dietary Patterns, Carbohydrates, and Age-Related Eye Diseases. Nutrients. 2020 Sep 18;12(9) PubMed PMID: 32962100.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Dietary Patterns, Carbohydrates, and Age-Related Eye Diseases. AU - Francisco,Sarah G, AU - Smith,Kelsey M, AU - Aragonès,Gemma, AU - Whitcomb,Elizabeth A, AU - Weinberg,Jasper, AU - Wang,Xuedi, AU - Bejarano,Eloy, AU - Taylor,Allen, AU - Rowan,Sheldon, Y1 - 2020/09/18/ PY - 2020/09/02/received PY - 2020/09/16/revised PY - 2020/09/16/accepted PY - 2020/9/23/entrez PY - 2020/9/24/pubmed PY - 2021/4/2/medline KW - Mediterranean diet KW - age-related macular degeneration KW - caloric restriction KW - cataract KW - diabetic retinopathy KW - dietary pattern KW - glaucoma KW - glycemic index KW - intermittent fasting JF - Nutrients JO - Nutrients VL - 12 IS - 9 N2 - Over a third of older adults in the U.S. experience significant vision loss, which decreases independence and is a biomarker of decreased health span. As the global aging population is expanding, it is imperative to uncover strategies to increase health span and reduce the economic burden of this age-related disease. While there are some treatments available for age-related vision loss, such as surgical removal of cataracts, many causes of vision loss, such as dry age-related macular degeneration (AMD), remain poorly understood and no treatments are currently available. Therefore, it is necessary to better understand the factors that contribute to disease progression for age-related vision loss and to uncover methods for disease prevention. One such factor is the effect of diet on ocular diseases. There are many reviews regarding micronutrients and their effect on eye health. Here, we discuss the impact of dietary patterns on the incidence and progression of age-related eye diseases, namely AMD, cataracts, diabetic retinopathy, and glaucoma. Then, we focus on the specific role of dietary carbohydrates, first by outlining the physiological effects of carbohydrates on the body and then how these changes translate into eye and age-related ocular diseases. Finally, we discuss future directions of nutrition research as it relates to aging and vision loss, with a discussion of caloric restriction, intermittent fasting, drug interventions, and emerging randomized clinical trials. This is a rich field with the capacity to improve life quality for millions of people so they may live with clear vision for longer and avoid the high cost of vision-saving surgeries. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/32962100/full_citation DB - PRIME DP - Unbound Medicine ER -