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Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers.
Molecules. 2020 Oct 11; 25(20)M

Abstract

Peptic ulcer disease is a common gastrointestinal tract disorder that affects up to 20% of the population of the world. Treatment of peptic ulcer remains challenging due to the limited effectiveness and severe side effects of the currently available drugs. Hence, natural compounds, owing to their medicinal, ecological, and other safe properties, are becoming popular potential candidates in preventing and treating peptic ulcers. Flavonoids, the most abundant polyphenols in plants, exhibit gastroprotective effects against peptic ulcer both in vivo and in vitro. In this review, we summarized the anti-ulcer functions and mechanisms, and also the bioavailability, efficacy, and safety, of flavonoid monomers in the gastrointestinal tract. Flavonoids exerted cytoprotective and rehabilitative effects by not only strengthening defense factors, such as mucus and prostaglandins, but also protecting against potentially harmful factors via their antioxidative, anti-inflammatory, and antibacterial activities. Although controlled clinical studies are limited at present, flavonoids have shown a promising preventable and therapeutic potential in peptic ulcers.

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Authors+Show Affiliations

Tea Research Institute, Guangdong Academy of Agricultural Sciences or Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Guangzhou 510640, China.

School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China.

Tea Research Institute, Guangdong Academy of Agricultural Sciences or Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Guangzhou 510640, China.

Tea Research Institute, Guangdong Academy of Agricultural Sciences or Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Guangzhou 510640, China.

Tea Research Institute, Guangdong Academy of Agricultural Sciences or Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Guangzhou 510640, China.

Tea Research Institute, Guangdong Academy of Agricultural Sciences or Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Guangzhou 510640, China.

Tea Research Institute, Guangdong Academy of Agricultural Sciences or Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Guangzhou 510640, China.

School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China.

Tea Research Institute, Guangdong Academy of Agricultural Sciences or Guangdong Key Laboratory of Tea Resources Innovation & Utilization, Guangzhou 510640, China.

MeSH

Anti-Inflammatory AgentsAntioxidantsFlavonoidsHumansPeptic Ulcer

Pub Type(s)

Journal Article

Review

Language

eng

PubMed ID

33050668

Citation

Zhang, Wenji, et al. "Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers." Molecules (Basel, Switzerland), vol. 25, no. 20, 2020.

Zhang W, Lian Y, Li Q, et al. Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers. Molecules. 2020;25(20).

Zhang, W., Lian, Y., Li, Q., Sun, L., Chen, R., Lai, X., Lai, Z., Yuan, E., & Sun, S. (2020). Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers. Molecules (Basel, Switzerland), 25(20). https://doi.org/10.3390/molecules25204626

Zhang W, et al. Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers. Molecules. 2020 Oct 11;25(20) PubMed PMID: 33050668.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers. AU - Zhang,Wenji, AU - Lian,Yingyi, AU - Li,Qiuhua, AU - Sun,Lingli, AU - Chen,Ruohong, AU - Lai,Xingfei, AU - Lai,Zhaoxiang, AU - Yuan,Erdong, AU - Sun,Shili, Y1 - 2020/10/11/ PY - 2020/08/25/received PY - 2020/10/08/revised PY - 2020/10/10/accepted PY - 2020/10/14/entrez PY - 2020/10/15/pubmed PY - 2021/5/18/medline KW - anti-inflammation KW - antibacterial KW - antioxidation KW - flavonoids KW - gastroprotective effects KW - peptic ulcer JF - Molecules (Basel, Switzerland) JO - Molecules VL - 25 IS - 20 N2 - Peptic ulcer disease is a common gastrointestinal tract disorder that affects up to 20% of the population of the world. Treatment of peptic ulcer remains challenging due to the limited effectiveness and severe side effects of the currently available drugs. Hence, natural compounds, owing to their medicinal, ecological, and other safe properties, are becoming popular potential candidates in preventing and treating peptic ulcers. Flavonoids, the most abundant polyphenols in plants, exhibit gastroprotective effects against peptic ulcer both in vivo and in vitro. In this review, we summarized the anti-ulcer functions and mechanisms, and also the bioavailability, efficacy, and safety, of flavonoid monomers in the gastrointestinal tract. Flavonoids exerted cytoprotective and rehabilitative effects by not only strengthening defense factors, such as mucus and prostaglandins, but also protecting against potentially harmful factors via their antioxidative, anti-inflammatory, and antibacterial activities. Although controlled clinical studies are limited at present, flavonoids have shown a promising preventable and therapeutic potential in peptic ulcers. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/33050668/full_citation DB - PRIME DP - Unbound Medicine ER -