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Oxygen radicals and human disease.

Abstract

Toxic oxygen free radicals have been implicated as important pathologic mediators in many clinical disorders. We discuss the chemistry of oxygen radical production and the roles of iron and of various antioxidants as well as the diseases that have received active attention in oxy-radical research. Particular attention is focused on cigarette smoke oxidants, ischemia-reperfusion-induced radical production, carcinogenesis, and aging. Such research may well provide a firm foundation for therapeutic breakthroughs.

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  • Publisher Full Text
  • Authors

    , , , , , , ,

    Source

    Annals of internal medicine 107:4 1987 Oct pg 526-45

    MeSH

    Aging
    Animals
    DNA Damage
    Disease
    Free Radicals
    Humans
    Iron
    Ischemia
    Neoplasms
    Oxidation-Reduction
    Oxygen
    Smoking

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, Non-P.H.S.
    Research Support, U.S. Gov't, P.H.S.
    Review

    Language

    eng

    PubMed ID

    3307585

    Citation

    Cross, C E., et al. "Oxygen Radicals and Human Disease." Annals of Internal Medicine, vol. 107, no. 4, 1987, pp. 526-45.
    Cross CE, Halliwell B, Borish ET, et al. Oxygen radicals and human disease. Ann Intern Med. 1987;107(4):526-45.
    Cross, C. E., Halliwell, B., Borish, E. T., Pryor, W. A., Ames, B. N., Saul, R. L., ... Harman, D. (1987). Oxygen radicals and human disease. Annals of Internal Medicine, 107(4), pp. 526-45.
    Cross CE, et al. Oxygen Radicals and Human Disease. Ann Intern Med. 1987;107(4):526-45. PubMed PMID: 3307585.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Oxygen radicals and human disease. AU - Cross,C E, AU - Halliwell,B, AU - Borish,E T, AU - Pryor,W A, AU - Ames,B N, AU - Saul,R L, AU - McCord,J M, AU - Harman,D, PY - 1987/10/1/pubmed PY - 1987/10/1/medline PY - 1987/10/1/entrez SP - 526 EP - 45 JF - Annals of internal medicine JO - Ann. Intern. Med. VL - 107 IS - 4 N2 - Toxic oxygen free radicals have been implicated as important pathologic mediators in many clinical disorders. We discuss the chemistry of oxygen radical production and the roles of iron and of various antioxidants as well as the diseases that have received active attention in oxy-radical research. Particular attention is focused on cigarette smoke oxidants, ischemia-reperfusion-induced radical production, carcinogenesis, and aging. Such research may well provide a firm foundation for therapeutic breakthroughs. SN - 0003-4819 UR - https://www.unboundmedicine.com/medline/citation/3307585/full_citation L2 - https://www.annals.org/article.aspx?volume=107&issue=4&page=526 DB - PRIME DP - Unbound Medicine ER -