Differences in gray matter volume in episodic migraine patients with and without prior diagnosis or clinical care: a cross-sectional study.
J Headache Pain. 2021 Oct 23; 22(1):127.JH

Abstract

BACKGROUND

Migraine sufferers face difficulties getting appropriate care and treatment. Migraine is associated with reduced gray matter volume (GMV) in several brain regions, which could be related to various clinical characteristics of the disorder.

OBJECTIVES

To examine differences in GMV in migraine patients with and without prior clinical care for migraine and examine differences in migraine clinical variables, psychosocial symptoms and their relationship with GMV.

METHODS

We utilized the baseline MRI scan and psychosocial symptom questionnaires from a longitudinal randomized controlled trial. Prior care of migraine was determined by diagnosis by a medical practitioner or prescription of migraine specific medication.

RESULTS

117 patients were included in the study. Patients without prior care (n=23) had reduced GMV in the right dorsal medial prefrontal cortex (dMPFC) relative to patients who had prior care (p=0.034, FWE corrected). Both patient groups had reduced GMV compared to healthy controls (n=36). Patient groups did not differ in headache clinical variables. Regardless of care status, increasing scores on the stress (Perceived Stress Score) and depression questionnaires (Patient Health Questionnaire) were associated with increased GMV in the dMPFC.

CONCLUSIONS

Clinical care may impact GMV in migraine patients. Patients may need different treatment options to address this baseline deficit.

TRIAL REGISTRATION

NCT02133209.

Links

PMC Free PDF

Authors+Show Affiliations

Burrowes SAB

Section of Infectious Diseases, Department of Medicine, Boston University School of Medicine, 02218, Boston, MA, USA. shanab@bu.edu. Department of Neural and Pain Sciences, School of Dentistry, University of Maryland Baltimore, 21201, Baltimore, MD, USA. shanab@bu.edu. Center to Advance Chronic Pain Research, University of Maryland Baltimore, 21201, Baltimore, MD, USA. shanab@bu.edu. Department of Epidemiology and Public Health, School of Medicine, University of Maryland Baltimore, 21201, Baltimore, MD, USA. shanab@bu.edu. Boston University School of Medicine, 801 Massachusetts Avenue Room 2004, MA, 02118, Boston, USA. shanab@bu.edu.

Goloubeva O

Greenebaum Comprehensive Cancer Center, University of Maryland, University of Maryland Baltimore, 21201, Baltimore, MD, USA.

Keaser ML

Department of Neural and Pain Sciences, School of Dentistry, University of Maryland Baltimore, 21201, Baltimore, MD, USA. Center to Advance Chronic Pain Research, University of Maryland Baltimore, 21201, Baltimore, MD, USA.

Haythornthwaite JA

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Seminowicz DA

MeSH

BrainCross-Sectional StudiesGray MatterHumansMagnetic Resonance ImagingMigraine Disorders

Pub Type(s)

Journal Article

Randomized Controlled Trial

Language

eng

PubMed ID

34688253

Clinical Trial Links

Clinical trial which this article describes

Citation

Burrowes, Shana A B., et al. "Differences in Gray Matter Volume in Episodic Migraine Patients With and Without Prior Diagnosis or Clinical Care: a Cross-sectional Study." The Journal of Headache and Pain, vol. 22, no. 1, 2021, p. 127.

Burrowes SAB, Goloubeva O, Keaser ML, et al. Differences in gray matter volume in episodic migraine patients with and without prior diagnosis or clinical care: a cross-sectional study. J Headache Pain. 2021;22(1):127.

Burrowes, S. A. B., Goloubeva, O., Keaser, M. L., Haythornthwaite, J. A., & Seminowicz, D. A. (2021). Differences in gray matter volume in episodic migraine patients with and without prior diagnosis or clinical care: a cross-sectional study. The Journal of Headache and Pain, 22(1), 127. https://doi.org/10.1186/s10194-021-01340-5

Burrowes SAB, et al. Differences in Gray Matter Volume in Episodic Migraine Patients With and Without Prior Diagnosis or Clinical Care: a Cross-sectional Study. J Headache Pain. 2021 Oct 23;22(1):127. PubMed PMID: 34688253.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Differences in gray matter volume in episodic migraine patients with and without prior diagnosis or clinical care: a cross-sectional study. AU - Burrowes,Shana A B, AU - Goloubeva,Olga, AU - Keaser,Michael L, AU - Haythornthwaite,Jennifer A, AU - Seminowicz,David A, Y1 - 2021/10/23/ PY - 2021/8/23/received PY - 2021/10/6/accepted PY - 2021/10/24/entrez PY - 2021/10/25/pubmed PY - 2021/10/27/medline KW - Depression KW - Gray matter volume KW - Headache KW - MRI KW - Migraine KW - Prior care KW - Stress KW - Treatment naïve SP - 127 EP - 127 JF - The journal of headache and pain JO - J Headache Pain VL - 22 IS - 1 N2 - BACKGROUND: Migraine sufferers face difficulties getting appropriate care and treatment. Migraine is associated with reduced gray matter volume (GMV) in several brain regions, which could be related to various clinical characteristics of the disorder. OBJECTIVES: To examine differences in GMV in migraine patients with and without prior clinical care for migraine and examine differences in migraine clinical variables, psychosocial symptoms and their relationship with GMV. METHODS: We utilized the baseline MRI scan and psychosocial symptom questionnaires from a longitudinal randomized controlled trial. Prior care of migraine was determined by diagnosis by a medical practitioner or prescription of migraine specific medication. RESULTS: 117 patients were included in the study. Patients without prior care (n=23) had reduced GMV in the right dorsal medial prefrontal cortex (dMPFC) relative to patients who had prior care (p=0.034, FWE corrected). Both patient groups had reduced GMV compared to healthy controls (n=36). Patient groups did not differ in headache clinical variables. Regardless of care status, increasing scores on the stress (Perceived Stress Score) and depression questionnaires (Patient Health Questionnaire) were associated with increased GMV in the dMPFC. CONCLUSIONS: Clinical care may impact GMV in migraine patients. Patients may need different treatment options to address this baseline deficit. TRIAL REGISTRATION: NCT02133209. SN - 1129-2377 UR - https://www.unboundmedicine.com/medline/citation/34688253 DB - PRIME DP - Unbound Medicine ER -

Tags

Differences in gray matter volume in episodic migraine patients with and without prior diagnosis or clinical care: a cross-sectional study.J Headache Pain. 2021 Oct 23; 22(1):127.JH