COVID-19 and Selenium Deficiency: a Systematic Review.
Biol Trace Elem Res. 2022 Sep; 200(9):3945-3956.BT

Abstract

Several studies have indicated that selenium deficiency may be detrimental in the context of various viral disorders, and in the case of COVID-19, several studies have reported heterogeneous results concerning the association of selenium deficiency with the severity of disease. To summarize the available data surrounding the association of body selenium levels with the outcomes of COVID-19, a systematic search was performed in the Medline database (PubMed), Scopus, Cochrane Library, Embase, and Web of Science using keywords including "SARS-CoV-2," "COVID-19," and "selenium," Studies evaluating the association of COVID-19 with body selenium levels were included. Among 1,862 articles viewed in the database search, 10 articles were included after title, abstract, and full-text review. One study was further included after searching the literature again for any newly published articles. Out of 11 included studies, 10 studies measured serum selenium level, and one study investigated urinary selenium level. Three of 10 studies measured serum SELENOP level as well as selenium level. Glutathione peroxidase-3 level in serum was also assessed in one study. The reported outcomes were severity, mortality, and risk of COVID-19. Nine studies indicated that a lower serum selenium level is associated with worse outcomes. Two studies reported no significant association between serum selenium level and COVID-19. In one study, urinary selenium level was reported to be higher in severe and fatal cases compared to non-severe and recovered patients, respectively. In most cases, selenium deficiency was associated with worse outcomes, and selenium levels in COVID-19 patients were lower than in healthy individuals. Thus, it could be concluded that cautious selenium supplementation in COVID-19 patients may be helpful to prevent disease progression. However, randomized clinical trials are needed to confirm this.

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Authors+Show Affiliations

Fakhrolmobasheri M

Isfahan Cardiovascular Research Center (Heart Failure Research Center), 81746-73461, Isfahan, Iran.

Mazaheri-Tehrani S

Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, 81746-73461, Isfahan, Iran.

Kieliszek M

Department of Food Biotechnology and Microbiology, Institute of Food Sciences, Warsaw University of Life Sciences - SGGW, Nowoursynowska 159C, 02-776, Warsaw, Poland. marek_kieliszek@sggw.edu.pl.

Zeinalian M

Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, 81746-73461, Isfahan, Iran. zeinalianmehrdad@gmail.com.

Abbasi M

School of Medicine, Isfahan University of Medical Sciences, 81746-73461, Esfahan, Iran.

Karimi F

Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, 81746-73461, Isfahan, Iran.

Mozafari AM

Medical Library and Information Sciences Department, Health Information Technology Research Center, School of Management and Medical Information Sciences, Isfahan University of Medical Sciences, 81746-73461, Isfahan, Iran.

MeSH

COVID-19HumansMalnutritionSARS-CoV-2SeleniumSelenoprotein P

Pub Type(s)

Journal Article

Systematic Review

Language

eng

PubMed ID

34739678

Citation

Fakhrolmobasheri, Mohammad, et al. "COVID-19 and Selenium Deficiency: a Systematic Review." Biological Trace Element Research, vol. 200, no. 9, 2022, pp. 3945-3956.

Fakhrolmobasheri M, Mazaheri-Tehrani S, Kieliszek M, et al. COVID-19 and Selenium Deficiency: a Systematic Review. Biol Trace Elem Res. 2022;200(9):3945-3956.

Fakhrolmobasheri, M., Mazaheri-Tehrani, S., Kieliszek, M., Zeinalian, M., Abbasi, M., Karimi, F., & Mozafari, A. M. (2022). COVID-19 and Selenium Deficiency: a Systematic Review. Biological Trace Element Research, 200(9), 3945-3956. https://doi.org/10.1007/s12011-021-02997-4

Fakhrolmobasheri M, et al. COVID-19 and Selenium Deficiency: a Systematic Review. Biol Trace Elem Res. 2022;200(9):3945-3956. PubMed PMID: 34739678.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - COVID-19 and Selenium Deficiency: a Systematic Review. AU - Fakhrolmobasheri,Mohammad, AU - Mazaheri-Tehrani,Sadegh, AU - Kieliszek,Marek, AU - Zeinalian,Mehrdad, AU - Abbasi,Mehdi, AU - Karimi,Fateme, AU - Mozafari,Amir Mohamad, Y1 - 2021/11/05/ PY - 2021/08/20/received PY - 2021/10/24/accepted PY - 2021/11/6/pubmed PY - 2022/8/17/medline PY - 2021/11/5/entrez KW - COVID-19 KW - Micronutrients KW - Oxidative stress KW - SARS-CoV-2 KW - Selenium KW - Trace elements SP - 3945 EP - 3956 JF - Biological trace element research JO - Biol Trace Elem Res VL - 200 IS - 9 N2 - Several studies have indicated that selenium deficiency may be detrimental in the context of various viral disorders, and in the case of COVID-19, several studies have reported heterogeneous results concerning the association of selenium deficiency with the severity of disease. To summarize the available data surrounding the association of body selenium levels with the outcomes of COVID-19, a systematic search was performed in the Medline database (PubMed), Scopus, Cochrane Library, Embase, and Web of Science using keywords including "SARS-CoV-2," "COVID-19," and "selenium," Studies evaluating the association of COVID-19 with body selenium levels were included. Among 1,862 articles viewed in the database search, 10 articles were included after title, abstract, and full-text review. One study was further included after searching the literature again for any newly published articles. Out of 11 included studies, 10 studies measured serum selenium level, and one study investigated urinary selenium level. Three of 10 studies measured serum SELENOP level as well as selenium level. Glutathione peroxidase-3 level in serum was also assessed in one study. The reported outcomes were severity, mortality, and risk of COVID-19. Nine studies indicated that a lower serum selenium level is associated with worse outcomes. Two studies reported no significant association between serum selenium level and COVID-19. In one study, urinary selenium level was reported to be higher in severe and fatal cases compared to non-severe and recovered patients, respectively. In most cases, selenium deficiency was associated with worse outcomes, and selenium levels in COVID-19 patients were lower than in healthy individuals. Thus, it could be concluded that cautious selenium supplementation in COVID-19 patients may be helpful to prevent disease progression. However, randomized clinical trials are needed to confirm this. SN - 1559-0720 UR - https://www.unboundmedicine.com/medline/citation/34739678/full_citation DB - PRIME DP - Unbound Medicine ER -

Tags

COVID-19 and Selenium Deficiency: a Systematic Review.Biol Trace Elem Res. 2022 Sep; 200(9):3945-3956.BT