Atherosclerosis: Recent developments.
Cell. 2022 May 12; 185(10):1630-1645.Cell

Abstract

Atherosclerosis is an inflammatory disease of the large arteries that is the major cause of cardiovascular disease (CVD) and stroke. Here, we review the current understanding of the molecular, cellular, genetic, and environmental contributions to atherosclerosis, from both individual pathway and systems perspectives. We place an emphasis on recent developments, some of which have yielded unexpected biology, including previously unknown heterogeneity of inflammatory and smooth muscle cells in atherosclerotic lesions, roles for senescence and clonal hematopoiesis, and links to the gut microbiome.

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Authors+Show Affiliations

Björkegren JLM

Department of Genetics and Genomic Sciences, Division of Cardiology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Medicine, Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. Electronic address: johan.bjorkegren@mssm.edu.

Lusis AJ

Department of Medicine/Division of Cardiology, Department of Microbiology, Immunology and Molecular Genetics, Department of Human Genetics, A2-237 Center for the Health Sciences, University of California, Los Angeles, Los Angeles, CA USA. Electronic address: jlusis@mednet.ucla.edu.

MeSH

ArteriesAtherosclerosisClonal HematopoiesisGastrointestinal MicrobiomeHumansMyocytes, Smooth Muscle

Pub Type(s)

Journal Article

Review

Research Support, Non-U.S. Gov't

Research Support, N.I.H., Extramural

Language

eng

PubMed ID

35504280

Citation

Björkegren, Johan L M., and Aldons J. Lusis. "Atherosclerosis: Recent Developments." Cell, vol. 185, no. 10, 2022, pp. 1630-1645.

Björkegren JLM, Lusis AJ. Atherosclerosis: Recent developments. Cell. 2022;185(10):1630-1645.

Björkegren, J. L. M., & Lusis, A. J. (2022). Atherosclerosis: Recent developments. Cell, 185(10), 1630-1645. https://doi.org/10.1016/j.cell.2022.04.004

Björkegren JLM, Lusis AJ. Atherosclerosis: Recent Developments. Cell. 2022 05 12;185(10):1630-1645. PubMed PMID: 35504280.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Atherosclerosis: Recent developments. AU - Björkegren,Johan L M, AU - Lusis,Aldons J, Y1 - 2022/05/02/ PY - 2022/01/28/received PY - 2022/03/30/revised PY - 2022/04/01/accepted PY - 2022/5/4/pubmed PY - 2022/5/18/medline PY - 2022/5/3/entrez SP - 1630 EP - 1645 JF - Cell JO - Cell VL - 185 IS - 10 N2 - Atherosclerosis is an inflammatory disease of the large arteries that is the major cause of cardiovascular disease (CVD) and stroke. Here, we review the current understanding of the molecular, cellular, genetic, and environmental contributions to atherosclerosis, from both individual pathway and systems perspectives. We place an emphasis on recent developments, some of which have yielded unexpected biology, including previously unknown heterogeneity of inflammatory and smooth muscle cells in atherosclerotic lesions, roles for senescence and clonal hematopoiesis, and links to the gut microbiome. SN - 1097-4172 UR - https://www.unboundmedicine.com/medline/citation/35504280/Atherosclerosis:_Recent_developments_ DB - PRIME DP - Unbound Medicine ER -

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Atherosclerosis: Recent developments.Cell. 2022 May 12; 185(10):1630-1645.Cell