Tags

Type your tag names separated by a space and hit enter

Vitamin D supplementation worsens Alzheimer's progression: Animal model and human cohort studies.
Aging Cell. 2022 Aug; 21(8):e13670.AC

Abstract

Vitamin D deficiency has been epidemiologically linked to Alzheimer's disease (AD) and other dementias, but no interventional studies have proved causality. Our previous work revealed that the genomic vitamin D receptor (VDR) is already converted into a non-genomic signaling pathway by forming a complex with p53 in the AD brain. Here, we extend our previous work to assess whether it is beneficial to supplement AD mice and humans with vitamin D. Intriguingly, we first observed that APP/PS1 mice fed a vitamin D-sufficient diet showed significantly lower levels of serum vitamin D, suggesting its deficiency may be a consequence not a cause of AD. Moreover, supplementation of vitamin D led to increased Aβ deposition and exacerbated AD. Mechanistically, vitamin D supplementation did not rescue the genomic VDR/RXR complex but instead enhanced the non-genomic VDR/p53 complex in AD brains. Consistently, our population-based longitudinal study also showed that dementia-free older adults (n = 14,648) taking vitamin D3 supplements for over 146 days/year were 1.8 times more likely to develop dementia than those not taking the supplements. Among those with pre-existing dementia (n = 980), those taking vitamin D3 supplements for over 146 days/year had 2.17 times the risk of mortality than those not taking the supplements. Collectively, these animal model and human cohort studies caution against prolonged use of vitamin D by AD patients.

Links

PMC Free PDF

Authors+Show Affiliations

Lai RH
Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan.
Hsu CC
National Center for Geriatrics and Welfare Research, National Health Research Institutes, Miaoli, Taiwan. Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan. Department of Health Services Administration, China Medical University, Taichung, Taiwan. Department of Family Medicine, Min-Sheng General Hospital, Taoyuan, Taiwan.
Yu BH
Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
Lo YR
Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
Hsu YY
Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan.
Chen MH
Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan.
Juang JL
Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan. Ph.D. Program for Aging, China Medical University, Taichung, Taiwan.

MeSH

AgedAlzheimer DiseaseAnimalsCohort StudiesDietary SupplementsDisease Models, AnimalHumansLongitudinal StudiesMiceTumor Suppressor Protein p53Vitamin D

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

35822270

Citation

Lai, Rai-Hua, et al. "Vitamin D Supplementation Worsens Alzheimer's Progression: Animal Model and Human Cohort Studies." Aging Cell, vol. 21, no. 8, 2022, pp. e13670.
Lai RH, Hsu CC, Yu BH, et al. Vitamin D supplementation worsens Alzheimer's progression: Animal model and human cohort studies. Aging Cell. 2022;21(8):e13670.
Lai, R. H., Hsu, C. C., Yu, B. H., Lo, Y. R., Hsu, Y. Y., Chen, M. H., & Juang, J. L. (2022). Vitamin D supplementation worsens Alzheimer's progression: Animal model and human cohort studies. Aging Cell, 21(8), e13670. https://doi.org/10.1111/acel.13670
Lai RH, et al. Vitamin D Supplementation Worsens Alzheimer's Progression: Animal Model and Human Cohort Studies. Aging Cell. 2022;21(8):e13670. PubMed PMID: 35822270.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D supplementation worsens Alzheimer's progression: Animal model and human cohort studies. AU - Lai,Rai-Hua, AU - Hsu,Chih-Cheng, AU - Yu,Ben-Hui, AU - Lo,Yu-Ru, AU - Hsu,Yueh-Ying, AU - Chen,Mei-Hsin, AU - Juang,Jyh-Lyh, Y1 - 2022/07/12/ PY - 2022/06/24/revised PY - 2022/04/03/received PY - 2022/06/28/accepted PY - 2022/7/14/pubmed PY - 2022/8/19/medline PY - 2022/7/13/entrez KW - Alzheimer's disease KW - longitudinal study KW - non-genomic vitamin D signaling KW - p53 KW - vitamin D KW - vitamin D receptor SP - e13670 EP - e13670 JF - Aging cell JO - Aging Cell VL - 21 IS - 8 N2 - Vitamin D deficiency has been epidemiologically linked to Alzheimer's disease (AD) and other dementias, but no interventional studies have proved causality. Our previous work revealed that the genomic vitamin D receptor (VDR) is already converted into a non-genomic signaling pathway by forming a complex with p53 in the AD brain. Here, we extend our previous work to assess whether it is beneficial to supplement AD mice and humans with vitamin D. Intriguingly, we first observed that APP/PS1 mice fed a vitamin D-sufficient diet showed significantly lower levels of serum vitamin D, suggesting its deficiency may be a consequence not a cause of AD. Moreover, supplementation of vitamin D led to increased Aβ deposition and exacerbated AD. Mechanistically, vitamin D supplementation did not rescue the genomic VDR/RXR complex but instead enhanced the non-genomic VDR/p53 complex in AD brains. Consistently, our population-based longitudinal study also showed that dementia-free older adults (n = 14,648) taking vitamin D3 supplements for over 146 days/year were 1.8 times more likely to develop dementia than those not taking the supplements. Among those with pre-existing dementia (n = 980), those taking vitamin D3 supplements for over 146 days/year had 2.17 times the risk of mortality than those not taking the supplements. Collectively, these animal model and human cohort studies caution against prolonged use of vitamin D by AD patients. SN - 1474-9726 UR - https://www.unboundmedicine.com/medline/citation/35822270/full_citation DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓34 ↑37]

Related Citations

    More

    Others Viewed