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Association of vitamin E intake in diet and supplements with risk of dementia: A meta-analysis.
Front Aging Neurosci. 2022; 14:955878.FA

Abstract

Background

Dementia is a chronic progressive neurodegenerative disease that can lead to disability and death in humans, but there is still no effective prevention and treatment. Due to the neuroprotective effects of vitamin E, a large number of researchers have explored whether vitamin E can reduce the risk of dementia. Some researchers believe that vitamin E can reduce the risk of dementia, while others hold the opposite conclusion. We therefore performed a meta-analysis to clarify the relationship between them.

Methods

We searched PubMed, Embase, and Web of Science databases for articles on the connection of dietary and supplementation vitamin E with dementia risk from inception through April 2022 using the main keywords "dementia," "Alzheimer's disease," "vitamin E," and "tocopherol," and used a random-utility model for pooled effect sizes. Odds ratios (OR) and 95% confidence intervals were derived using lower and higher doses as contrasts. Obtained data were shown and assessed using Stata12.0 free software.

Results

We included 15 articles in sum. Among them, there were nine articles containing AD. By comparing the highest intake with the lowest intake, Combined ORs for high intake were as follows: dementia (OR = 0.79, 95% CI 0.70-0.88 I 2 = 35.0%), Alzheimer's disease (OR = 0.78, 95% CI 0.64-0.94 I 2 = 36.9%). Subgroup analyses were also performed by study type, diet and supplementation, and NOS score.

Conclusions

High vitamin E intake from diet and supplements significantly reduces the risk of dementia and Alzheimer's disease.

Links

Authors+Show Affiliations

Gansu University of Chinese Medicine, First Clinical Medical College, Lanzhou, China. Sino-French Department of Neurological Rehabilitation, Gansu Provincial Hospital, Lanzhou, China.

Graduate School, Ning Xia Medical University, Yinchuan, China.

Sino-French Department of Neurological Rehabilitation, Gansu Provincial Hospital, Lanzhou, China.

Sino-French Department of Neurological Rehabilitation, Gansu Provincial Hospital, Lanzhou, China.

Sino-French Department of Neurological Rehabilitation, Gansu Provincial Hospital, Lanzhou, China.

Sino-French Department of Neurological Rehabilitation, Gansu Provincial Hospital, Lanzhou, China.

Sino-French Department of Neurological Rehabilitation, Gansu Provincial Hospital, Lanzhou, China.

Lanzhou No.1 People's Hospital, Lanzhou, China.

General Surgery Clinical Medical Center, Gansu Provincial Hospital, Lanzhou, China. Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province, Gansu Provincial Hospital, Lanzhou, China. First Clinical College of Medicine, Lanzhou University, Lanzhou, China. NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Gansu Provincial Hospital, Lanzhou, China.

Sino-French Department of Neurological Rehabilitation, Gansu Provincial Hospital, Lanzhou, China.

Pub Type(s)

Systematic Review

Language

eng

PubMed ID

35978949

Citation

Zhao, Rangyin, et al. "Association of Vitamin E Intake in Diet and Supplements With Risk of Dementia: a Meta-analysis." Frontiers in Aging Neuroscience, vol. 14, 2022, p. 955878.

Zhao R, Han X, Zhang H, et al. Association of vitamin E intake in diet and supplements with risk of dementia: A meta-analysis. Front Aging Neurosci. 2022;14:955878.

Zhao, R., Han, X., Zhang, H., Liu, J., Zhang, M., Zhao, W., Jiang, S., Li, R., Cai, H., & You, H. (2022). Association of vitamin E intake in diet and supplements with risk of dementia: A meta-analysis. Frontiers in Aging Neuroscience, 14, 955878. https://doi.org/10.3389/fnagi.2022.955878

Zhao R, et al. Association of Vitamin E Intake in Diet and Supplements With Risk of Dementia: a Meta-analysis. Front Aging Neurosci. 2022;14:955878. PubMed PMID: 35978949.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Association of vitamin E intake in diet and supplements with risk of dementia: A meta-analysis. AU - Zhao,Rangyin, AU - Han,Xiaoyong, AU - Zhang,Hongxia, AU - Liu,Jia, AU - Zhang,Min, AU - Zhao,Weijing, AU - Jiang,Shangrong, AU - Li,Ruilin, AU - Cai,Hui, AU - You,Hong, Y1 - 2022/08/01/ PY - 2022/05/29/received PY - 2022/07/12/accepted PY - 2022/8/18/entrez PY - 2022/8/19/pubmed PY - 2022/8/19/medline KW - dementia KW - diet KW - meta-analysis KW - risk KW - supplements KW - vitamin E SP - 955878 EP - 955878 JF - Frontiers in aging neuroscience JO - Front Aging Neurosci VL - 14 N2 - Background: Dementia is a chronic progressive neurodegenerative disease that can lead to disability and death in humans, but there is still no effective prevention and treatment. Due to the neuroprotective effects of vitamin E, a large number of researchers have explored whether vitamin E can reduce the risk of dementia. Some researchers believe that vitamin E can reduce the risk of dementia, while others hold the opposite conclusion. We therefore performed a meta-analysis to clarify the relationship between them. Methods: We searched PubMed, Embase, and Web of Science databases for articles on the connection of dietary and supplementation vitamin E with dementia risk from inception through April 2022 using the main keywords "dementia," "Alzheimer's disease," "vitamin E," and "tocopherol," and used a random-utility model for pooled effect sizes. Odds ratios (OR) and 95% confidence intervals were derived using lower and higher doses as contrasts. Obtained data were shown and assessed using Stata12.0 free software. Results: We included 15 articles in sum. Among them, there were nine articles containing AD. By comparing the highest intake with the lowest intake, Combined ORs for high intake were as follows: dementia (OR = 0.79, 95% CI 0.70-0.88 I 2 = 35.0%), Alzheimer's disease (OR = 0.78, 95% CI 0.64-0.94 I 2 = 36.9%). Subgroup analyses were also performed by study type, diet and supplementation, and NOS score. Conclusions: High vitamin E intake from diet and supplements significantly reduces the risk of dementia and Alzheimer's disease. SN - 1663-4365 UR - https://www.unboundmedicine.com/medline/citation/35978949/full_citation DB - PRIME DP - Unbound Medicine ER -