Association of late-life body mass index with the risk of Alzheimer disease: a 10-year nationwide population-based cohort study.
Sci Rep. 2022 Sep 12; 12(1):15298.SR

Abstract

Existing data for the association between late-life body mass index (BMI) and the risk of Alzheimer's disease (AD) in the underweight population are limited with conflicting results. A large population-based cohort study of 148,534 individuals aged ≥ 65 years who participated in the national health screening program from 2002 to 2005 was performed using the Korean National Health Insurance Service-Senior cohort database 2006-2015. The risk of AD according to BMI category (kg/m2) in Asians was evaluated using a multivariable Cox regression model, after adjustments for age, sex, lifestyle, low-income status, and comorbidities. To evaluate the association between BMI and AD risk, the underweight population was further subdivided according to the degree of thinness. During the 10-year follow-up period, 22,279 individuals developed AD. Relative to the normal-weight population, the estimated adjusted hazard ratio (HR) for incident AD in the underweight, overweight, and obese populations was 1.17 (95% confidence interval [CI], 1.09-1.24), 0.90 (0.87-0.93), and 0.83 (0.80-0.85), respectively. In the underweight population, AD risk increased as the degree of thinness increased (p for the trend, < .001). Late-life BMI showed a significant inverse relationship with AD risk, especially in the underweight population. Public health strategies to screen for AD more actively in the underweight population and improve their weight status may help reduce the burden of AD.

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Authors+Show Affiliations

Cho SH

Department of Family Medicine, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

Jang M

Department of Family Medicine, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

Ju H

Department of Family Medicine, Dankook University Hospital, 201, Manghyang-ro, Dongnam-gu, Cheonan, Chung Nam, 31116, Republic of Korea.

Kang MJ

Department of Neurology, Veterans Health Service Medical Center, Seoul, Republic of Korea.

Yun JM

Department of Family Medicine, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea. jaemoon2@gmail.com.

Yun JW

Veterans Health Service Medical Center, Veterans Medical Research Institute, Jinhwangdo-ro 61-gil 53, Gangdong-gu, Seoul, 05368, Republic of Korea. jwyunmd@gmail.com.

MeSH

Alzheimer DiseaseBody Mass IndexCohort StudiesHumansRisk FactorsThinness

Pub Type(s)

Journal Article

Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

36097042

Citation

Cho, Su Hwan, et al. "Association of Late-life Body Mass Index With the Risk of Alzheimer Disease: a 10-year Nationwide Population-based Cohort Study." Scientific Reports, vol. 12, no. 1, 2022, p. 15298.

Cho SH, Jang M, Ju H, et al. Association of late-life body mass index with the risk of Alzheimer disease: a 10-year nationwide population-based cohort study. Sci Rep. 2022;12(1):15298.

Cho, S. H., Jang, M., Ju, H., Kang, M. J., Yun, J. M., & Yun, J. W. (2022). Association of late-life body mass index with the risk of Alzheimer disease: a 10-year nationwide population-based cohort study. Scientific Reports, 12(1), 15298. https://doi.org/10.1038/s41598-022-19696-2

Cho SH, et al. Association of Late-life Body Mass Index With the Risk of Alzheimer Disease: a 10-year Nationwide Population-based Cohort Study. Sci Rep. 2022 Sep 12;12(1):15298. PubMed PMID: 36097042.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Association of late-life body mass index with the risk of Alzheimer disease: a 10-year nationwide population-based cohort study. AU - Cho,Su Hwan, AU - Jang,Minseol, AU - Ju,Hyorim, AU - Kang,Min Ju, AU - Yun,Jae Moon, AU - Yun,Jae Won, Y1 - 2022/09/12/ PY - 2022/04/13/received PY - 2022/09/02/accepted PY - 2022/9/12/entrez PY - 2022/9/13/pubmed PY - 2022/9/15/medline SP - 15298 EP - 15298 JF - Scientific reports JO - Sci Rep VL - 12 IS - 1 N2 - Existing data for the association between late-life body mass index (BMI) and the risk of Alzheimer's disease (AD) in the underweight population are limited with conflicting results. A large population-based cohort study of 148,534 individuals aged ≥ 65 years who participated in the national health screening program from 2002 to 2005 was performed using the Korean National Health Insurance Service-Senior cohort database 2006-2015. The risk of AD according to BMI category (kg/m2) in Asians was evaluated using a multivariable Cox regression model, after adjustments for age, sex, lifestyle, low-income status, and comorbidities. To evaluate the association between BMI and AD risk, the underweight population was further subdivided according to the degree of thinness. During the 10-year follow-up period, 22,279 individuals developed AD. Relative to the normal-weight population, the estimated adjusted hazard ratio (HR) for incident AD in the underweight, overweight, and obese populations was 1.17 (95% confidence interval [CI], 1.09-1.24), 0.90 (0.87-0.93), and 0.83 (0.80-0.85), respectively. In the underweight population, AD risk increased as the degree of thinness increased (p for the trend, < .001). Late-life BMI showed a significant inverse relationship with AD risk, especially in the underweight population. Public health strategies to screen for AD more actively in the underweight population and improve their weight status may help reduce the burden of AD. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/36097042/full_citation DB - PRIME DP - Unbound Medicine ER -

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Association of late-life body mass index with the risk of Alzheimer disease: a 10-year nationwide population-based cohort study.Sci Rep. 2022 Sep 12; 12(1):15298.SR