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Mercury Exposure and Risk of Type 2 Diabetes: A Systematic Review and Meta-Analysis.
Int J Clin Pract. 2022; 2022:7640227.IJ

Abstract

METHODS

Scopus and PubMed databases were systematically searched from their inception to November 2021 to obtain pertinent studies. Standardized mean differences (SMDs) with corresponding 95% confidence intervals (CIs) were calculated to evaluate the difference in Hg levels between people with and without T2DM. The association of the Hg exposure with T2DM was assessed using a random-effects model by pooling the odds ratios (ORs) and 95% CIs.

RESULTS

A total of 17 studies, with 42,917 participants, aged ≥18 years, were analyzed. Overall, Hg levels were significantly higher in T2DM patients compared with non-T2DM controls (SMD = 1.07; 95%CI = 0.59 to 1.55, P ≤ 0.001), with significant heterogeneity across studies (I2 = 96.1%; P=≤0.001). No significant association was found between Hg exposure and risk of T2DM in the overall analysis and subgroup analysis based on the source of sample and study design. However, higher exposure to Hg was related to reduced risk of T2DM in men (OR = 0.71; 95%CI = 0.57 to 0.88), but not in women. No significant evidence for publication bias was detected.

CONCLUSIONS

Although the Hg level in T2DM is significantly higher than that of nondiabetics, there was no association between Hg exposure and the overall risk of T2DM. Nevertheless, our study shows that higher exposure to Hg might reduce the risk of T2DM in men.

Links

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Authors+Show Affiliations

Ghorbani Nejad B
Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman Medical University, Kerman, Iran.
Raeisi T
Department of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Janmohammadi P
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Mehravar F
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Zarei M
Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Dehghani A
Nutrition Research Center, Department of Community Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
Bahrampour N
Department of Nutrition, Science and Research Branch, Islamic Azad University (SRBIAU), Tehran, Iran.
Darijani MH
Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman Medical University, Kerman, Iran.
Ahmadipour F
Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman Medical University, Kerman, Iran.
Mohajeri M
Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman Medical University, Kerman, Iran.
Alizadeh S
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

MeSH

AdolescentAdultDiabetes Mellitus, Type 2FemaleHumansMaleMercuryOdds Ratio

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

36101810

Citation

Ghorbani Nejad, Behnam, et al. "Mercury Exposure and Risk of Type 2 Diabetes: a Systematic Review and Meta-Analysis." International Journal of Clinical Practice, vol. 2022, 2022, p. 7640227.
Ghorbani Nejad B, Raeisi T, Janmohammadi P, et al. Mercury Exposure and Risk of Type 2 Diabetes: A Systematic Review and Meta-Analysis. Int J Clin Pract. 2022;2022:7640227.
Ghorbani Nejad, B., Raeisi, T., Janmohammadi, P., Mehravar, F., Zarei, M., Dehghani, A., Bahrampour, N., Darijani, M. H., Ahmadipour, F., Mohajeri, M., & Alizadeh, S. (2022). Mercury Exposure and Risk of Type 2 Diabetes: A Systematic Review and Meta-Analysis. International Journal of Clinical Practice, 2022, 7640227. https://doi.org/10.1155/2022/7640227
Ghorbani Nejad B, et al. Mercury Exposure and Risk of Type 2 Diabetes: a Systematic Review and Meta-Analysis. Int J Clin Pract. 2022;2022:7640227. PubMed PMID: 36101810.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mercury Exposure and Risk of Type 2 Diabetes: A Systematic Review and Meta-Analysis. AU - Ghorbani Nejad,Behnam, AU - Raeisi,Tahereh, AU - Janmohammadi,Parisa, AU - Mehravar,Fatemeh, AU - Zarei,Mahtab, AU - Dehghani,Azadeh, AU - Bahrampour,Niki, AU - Darijani,Mohammad Hosein, AU - Ahmadipour,Fatemeh, AU - Mohajeri,Mohammad, AU - Alizadeh,Shahab, Y1 - 2022/09/02/ PY - 2022/3/3/received PY - 2022/8/2/revised PY - 2022/8/5/accepted PY - 2022/9/14/entrez PY - 2022/9/15/pubmed PY - 2022/9/16/medline SP - 7640227 EP - 7640227 JF - International journal of clinical practice JO - Int J Clin Pract VL - 2022 N2 - METHODS: Scopus and PubMed databases were systematically searched from their inception to November 2021 to obtain pertinent studies. Standardized mean differences (SMDs) with corresponding 95% confidence intervals (CIs) were calculated to evaluate the difference in Hg levels between people with and without T2DM. The association of the Hg exposure with T2DM was assessed using a random-effects model by pooling the odds ratios (ORs) and 95% CIs. RESULTS: A total of 17 studies, with 42,917 participants, aged ≥18 years, were analyzed. Overall, Hg levels were significantly higher in T2DM patients compared with non-T2DM controls (SMD = 1.07; 95%CI = 0.59 to 1.55, P ≤ 0.001), with significant heterogeneity across studies (I2 = 96.1%; P=≤0.001). No significant association was found between Hg exposure and risk of T2DM in the overall analysis and subgroup analysis based on the source of sample and study design. However, higher exposure to Hg was related to reduced risk of T2DM in men (OR = 0.71; 95%CI = 0.57 to 0.88), but not in women. No significant evidence for publication bias was detected. CONCLUSIONS: Although the Hg level in T2DM is significantly higher than that of nondiabetics, there was no association between Hg exposure and the overall risk of T2DM. Nevertheless, our study shows that higher exposure to Hg might reduce the risk of T2DM in men. SN - 1742-1241 UR - https://www.unboundmedicine.com/medline/citation/36101810/full_citation DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓12 ↑51]

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