Dietary fiber intake and risk of gallstone: a case-control study.
BMC Gastroenterol. 2023 Apr 11; 23(1):119.BG

Abstract

BACKGROUND

Gallstone disease (GSD) and its complications are major public health issues globally. Although many community-based studies had addressed the risk factors for GSD, little is known about the associations between dietary factors and risk of disease. The present study aimed to investigate the potential associations between dietary fibers with the risk of gallstone disease.

METHODS

In this case-control study, 189 GSD patients with less than one month of diagnosis and 342 age‑matched controls were enrolled. Dietary intakes were assessed using a 168-item semi-quantitative validated food frequency questionnaire. Crude and multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated through cox proportional hazards regression models.

RESULTS

Comparing the highest versus the lowest tertile, significant reverse associations were observed between odds of GSD and each category of dietary fiber intake including total (OR T3 vs. T1 = 0.44, 95% CI: 0.37-0.7, P for trend = 0.015), soluble (OR T3 vs. T1 = 0.51, 95% CI: 0.3-0.8, P for trend = 0.048) and insoluble (OR T3 vs. T1 = 0.56, 95% CI: 0.3-0.9, P for trend < 0.001). The relationship between dietary fiber intake and the risk of gallstones was more prominent in overweight and obese subjects than in subjects with a normal body mass index.

CONCLUSION

Comprehensive assessment of the associations of dietary fiber intake with GSD showed that higher intakes of dietary fiber were significantly associated with reduced GSD risk.

Links

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Authors+Show Affiliations

Tehrani AN

Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Saadati S

Department of Medicine, School of Clinical Sciences, Monash University, Melbourne, Australia.

Yari Z

Department of Nutrition Research, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences Tehran, West Arghavan St. Farahzadi Blvd., Sharake Qods, Tehran, Iran. zahrayari_nut@yahoo.com.

Salehpour A

School of Public Health, Occupational Health Research Center, Iran Universityof Medical Sciences, Tehran, Iran.

Sadeghi A

Research Institute for Gastroenterology and Liver Diseases of Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Daftari G

School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Ghorbani M

Department of Community Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

Hekmatdoost A

Clinical Nutrition and Dietetics Department, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences Tehran, Tehran, Iran.

MeSH

HumansGallstonesCase-Control StudiesRisk FactorsObesityDietary Fiber

Pub Type(s)

Journal Article

Language

eng

PubMed ID

37041462

Citation

Tehrani, Asal Neshatbini, et al. "Dietary Fiber Intake and Risk of Gallstone: a Case-control Study." BMC Gastroenterology, vol. 23, no. 1, 2023, p. 119.

Tehrani AN, Saadati S, Yari Z, et al. Dietary fiber intake and risk of gallstone: a case-control study. BMC Gastroenterol. 2023;23(1):119.

Tehrani, A. N., Saadati, S., Yari, Z., Salehpour, A., Sadeghi, A., Daftari, G., Ghorbani, M., & Hekmatdoost, A. (2023). Dietary fiber intake and risk of gallstone: a case-control study. BMC Gastroenterology, 23(1), 119. https://doi.org/10.1186/s12876-023-02752-0

Tehrani AN, et al. Dietary Fiber Intake and Risk of Gallstone: a Case-control Study. BMC Gastroenterol. 2023 Apr 11;23(1):119. PubMed PMID: 37041462.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Dietary fiber intake and risk of gallstone: a case-control study. AU - Tehrani,Asal Neshatbini, AU - Saadati,Saeede, AU - Yari,Zahra, AU - Salehpour,Amin, AU - Sadeghi,Amir, AU - Daftari,Ghazal, AU - Ghorbani,Moloud, AU - Hekmatdoost,Azita, Y1 - 2023/04/11/ PY - 2022/12/26/received PY - 2023/03/29/accepted PY - 2023/4/13/medline PY - 2023/4/11/entrez PY - 2023/4/12/pubmed KW - Cholelithiasis KW - Dietary fiber KW - Gallstone SP - 119 EP - 119 JF - BMC gastroenterology JO - BMC Gastroenterol VL - 23 IS - 1 N2 - BACKGROUND: Gallstone disease (GSD) and its complications are major public health issues globally. Although many community-based studies had addressed the risk factors for GSD, little is known about the associations between dietary factors and risk of disease. The present study aimed to investigate the potential associations between dietary fibers with the risk of gallstone disease. METHODS: In this case-control study, 189 GSD patients with less than one month of diagnosis and 342 age‑matched controls were enrolled. Dietary intakes were assessed using a 168-item semi-quantitative validated food frequency questionnaire. Crude and multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated through cox proportional hazards regression models. RESULTS: Comparing the highest versus the lowest tertile, significant reverse associations were observed between odds of GSD and each category of dietary fiber intake including total (OR T3 vs. T1 = 0.44, 95% CI: 0.37-0.7, P for trend = 0.015), soluble (OR T3 vs. T1 = 0.51, 95% CI: 0.3-0.8, P for trend = 0.048) and insoluble (OR T3 vs. T1 = 0.56, 95% CI: 0.3-0.9, P for trend < 0.001). The relationship between dietary fiber intake and the risk of gallstones was more prominent in overweight and obese subjects than in subjects with a normal body mass index. CONCLUSION: Comprehensive assessment of the associations of dietary fiber intake with GSD showed that higher intakes of dietary fiber were significantly associated with reduced GSD risk. SN - 1471-230X UR - https://www.unboundmedicine.com/medline/citation/37041462/full_citation DB - PRIME DP - Unbound Medicine ER -

Tags

Dietary fiber intake and risk of gallstone: a case-control study.BMC Gastroenterol. 2023 Apr 11; 23(1):119.BG