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The Effect of Cinnamon on Glycolipid Metabolism: A Dose-Response Meta-Analysis of Randomized Controlled Trials.
Nutrients. 2023 Jun 30; 15(13)N

Abstract

(1) Background: The effect of cinnamon on the regulation of glycolipid levels in type 2 diabetic patients is still controversial, and there is a lack of research on the dose-response relationship between cinnamon and glycolipid indicators in type 2 diabetic patients. (2) Methods: This dose-response meta-analysis was performed to explore the effect of the cinnamon intervention on glycolipid metabolism. We conducted a comprehensive database search for literature published before November 2022. Nonlinear models were used for dose-response relationship analysis. (3) Results: We identified that a cinnamon intervention was effective in controlling triglyceride (TG) levels (mean difference = -7.31; 95%CI: -12.37, -2.25, p = 0.005) and low-density lipoprotein cholesterol (LDL-C) levels (mean difference = -6.78; 95%CI: -11.35, -2.22, p = 0.004) in type 2 diabetic patients; however, it also was able to increase high-density lipoprotein cholesterol (HDL-C) levels in patients with type 2 diabetes (mean difference = 1.53; 95%CI: 1.01, 2.05, p < 0.001). However, the cinnamon intervention had no significant effect on the level of fasting blood glucose, glycated hemoglobin (HbA1c), or total cholesterol (TC) levels. We found a significant effect of the cinnamon intervention dose on the TG level (p-nonlinearity = 0.016) and LDL-C (p-nonlinearity = 0.019) in the nonlinear dose-response analysis. In the subgroup analysis, we found a hypoglycemic effect with the cinnamon dose ≤1200 mg (mean difference = -11.1, 95%CI: -14.64, -7.58, p < 0.001). (4) Conclusion: Cinnamon intervention may be beneficial in lowering TG and LDL-C levels while enhancing HDL-C levels, and the dosage of the intervention was an important factor in influencing the TG and LDL-C levels.

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Authors+Show Affiliations

Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China.

Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China.

Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China.

Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China.

Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China.

Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China.

Public Service Platform of South China Sea for R&D Marine Biomedicine Resources, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524023, China.

Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China.

MeSH

HumansDiabetes Mellitus, Type 2Cholesterol, LDLCinnamomum zeylanicumRandomized Controlled Trials as TopicGlycolipidsBlood GlucoseCholesterol, HDLTriglycerides

Pub Type(s)

Meta-Analysis

Journal Article

Review

Language

eng

PubMed ID

37447309

Citation

Yu, Tingqing, et al. "The Effect of Cinnamon On Glycolipid Metabolism: a Dose-Response Meta-Analysis of Randomized Controlled Trials." Nutrients, vol. 15, no. 13, 2023.

Yu T, Lu K, Cao X, et al. The Effect of Cinnamon on Glycolipid Metabolism: A Dose-Response Meta-Analysis of Randomized Controlled Trials. Nutrients. 2023;15(13).

Yu, T., Lu, K., Cao, X., Xia, H., Wang, S., Sun, G., Chen, L., & Liao, W. (2023). The Effect of Cinnamon on Glycolipid Metabolism: A Dose-Response Meta-Analysis of Randomized Controlled Trials. Nutrients, 15(13). https://doi.org/10.3390/nu15132983

Yu T, et al. The Effect of Cinnamon On Glycolipid Metabolism: a Dose-Response Meta-Analysis of Randomized Controlled Trials. Nutrients. 2023 Jun 30;15(13) PubMed PMID: 37447309.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - The Effect of Cinnamon on Glycolipid Metabolism: A Dose-Response Meta-Analysis of Randomized Controlled Trials. AU - Yu,Tingqing, AU - Lu,Kun, AU - Cao,Xinyi, AU - Xia,Hui, AU - Wang,Shaokang, AU - Sun,Guiju, AU - Chen,Liang, AU - Liao,Wang, Y1 - 2023/06/30/ PY - 2023/06/08/received PY - 2023/06/28/revised PY - 2023/06/29/accepted PY - 2023/7/17/medline PY - 2023/7/14/pubmed PY - 2023/7/14/entrez KW - cinnamon KW - dose–response KW - glycolipid metabolism KW - meta-analysis KW - randomized controlled trials JF - Nutrients JO - Nutrients VL - 15 IS - 13 N2 - (1) Background: The effect of cinnamon on the regulation of glycolipid levels in type 2 diabetic patients is still controversial, and there is a lack of research on the dose-response relationship between cinnamon and glycolipid indicators in type 2 diabetic patients. (2) Methods: This dose-response meta-analysis was performed to explore the effect of the cinnamon intervention on glycolipid metabolism. We conducted a comprehensive database search for literature published before November 2022. Nonlinear models were used for dose-response relationship analysis. (3) Results: We identified that a cinnamon intervention was effective in controlling triglyceride (TG) levels (mean difference = -7.31; 95%CI: -12.37, -2.25, p = 0.005) and low-density lipoprotein cholesterol (LDL-C) levels (mean difference = -6.78; 95%CI: -11.35, -2.22, p = 0.004) in type 2 diabetic patients; however, it also was able to increase high-density lipoprotein cholesterol (HDL-C) levels in patients with type 2 diabetes (mean difference = 1.53; 95%CI: 1.01, 2.05, p < 0.001). However, the cinnamon intervention had no significant effect on the level of fasting blood glucose, glycated hemoglobin (HbA1c), or total cholesterol (TC) levels. We found a significant effect of the cinnamon intervention dose on the TG level (p-nonlinearity = 0.016) and LDL-C (p-nonlinearity = 0.019) in the nonlinear dose-response analysis. In the subgroup analysis, we found a hypoglycemic effect with the cinnamon dose ≤1200 mg (mean difference = -11.1, 95%CI: -14.64, -7.58, p < 0.001). (4) Conclusion: Cinnamon intervention may be beneficial in lowering TG and LDL-C levels while enhancing HDL-C levels, and the dosage of the intervention was an important factor in influencing the TG and LDL-C levels. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/37447309/full_citation DB - PRIME DP - Unbound Medicine ER -