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The Impact of Routine Vaccinations on Alzheimer's Disease Risk in Persons 65 Years and Older: A Claims-Based Cohort Study using Propensity Score Matching.
J Alzheimers Dis. 2023; 95(2):703-718.JA

Abstract

BACKGROUND

Accumulating evidence suggests that adult vaccinations can reduce the risk of developing Alzheimer's disease (AD) and Alzheimer's disease related dementias.

OBJECTIVE

To compare the risk for developing AD between adults with and without prior vaccination against tetanus and diphtheria, with or without pertussis (Tdap/Td); herpes zoster (HZ); or pneumococcus.

METHODS

A retrospective cohort study was performed using Optum's de-identified Clinformatics® Data Mart Database. Included patients were free of dementia during a 2-year look-back period and were≥65 years old by the start of the 8-year follow-up period. We compared two similar cohorts identified using propensity score matching (PSM), one vaccinated and another unvaccinated, with Tdap/Td, HZ, or pneumococcal vaccines. We calculated the relative risk (RR) and absolute risk reduction (ARR) for developing AD.

RESULTS

For the Tdap/Td vaccine, 7.2% (n = 8,370) of vaccinated patients and 10.2% (n = 11,857) of unvaccinated patients developed AD during follow-up; the RR was 0.70 (95% CI, 0.68-0.72) and ARR was 0.03 (95% CI, 0.02-0.03). For the HZ vaccine, 8.1% (n = 16,106) of vaccinated patients and 10.7% (n = 21,417) of unvaccinated patients developed AD during follow-up; the RR was 0.75 (95% CI, 0.73-0.76) and ARR was 0.02 (95% CI, 0.02-0.02). For the pneumococcal vaccine, 7.92% (n = 20,583) of vaccinated patients and 10.9% (n = 28,558) of unvaccinated patients developed AD during follow-up; the RR was 0.73 (95% CI, 0.71-0.74) and ARR was 0.02 (95% CI, 0.02-0.03).

CONCLUSION

Several vaccinations, including Tdap/Td, HZ, and pneumococcal, are associated with a reduced risk for developing AD.

Links

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Authors+Show Affiliations

Harris K
Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Ling Y
School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX, USA.
Bukhbinder AS
Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA. Division of Pediatric Neurology, Massachusetts General Hospital, Boston, MA, USA.
Chen L
School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX, USA.
Phelps KN
Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Cruz G
Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Thomas J
Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Kim Y
School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX, USA.
Jiang X
School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX, USA.
Schulz PE
Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.

MeSH

HumansAgedDiphtheria-Tetanus-acellular Pertussis VaccinesCohort StudiesRetrospective StudiesAlzheimer DiseasePropensity ScoreVaccinationHerpes Zoster

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

37574727

Citation

Harris, Kristofer, et al. "The Impact of Routine Vaccinations On Alzheimer's Disease Risk in Persons 65 Years and Older: a Claims-Based Cohort Study Using Propensity Score Matching." Journal of Alzheimer's Disease : JAD, vol. 95, no. 2, 2023, pp. 703-718.
Harris K, Ling Y, Bukhbinder AS, et al. The Impact of Routine Vaccinations on Alzheimer's Disease Risk in Persons 65 Years and Older: A Claims-Based Cohort Study using Propensity Score Matching. J Alzheimers Dis. 2023;95(2):703-718.
Harris, K., Ling, Y., Bukhbinder, A. S., Chen, L., Phelps, K. N., Cruz, G., Thomas, J., Kim, Y., Jiang, X., & Schulz, P. E. (2023). The Impact of Routine Vaccinations on Alzheimer's Disease Risk in Persons 65 Years and Older: A Claims-Based Cohort Study using Propensity Score Matching. Journal of Alzheimer's Disease : JAD, 95(2), 703-718. https://doi.org/10.3233/JAD-221231
Harris K, et al. The Impact of Routine Vaccinations On Alzheimer's Disease Risk in Persons 65 Years and Older: a Claims-Based Cohort Study Using Propensity Score Matching. J Alzheimers Dis. 2023;95(2):703-718. PubMed PMID: 37574727.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Impact of Routine Vaccinations on Alzheimer's Disease Risk in Persons 65 Years and Older: A Claims-Based Cohort Study using Propensity Score Matching. AU - Harris,Kristofer, AU - Ling,Yaobin, AU - Bukhbinder,Avram S, AU - Chen,Luyao, AU - Phelps,Kamal N, AU - Cruz,Gabriela, AU - Thomas,Jenna, AU - Kim,Yejin, AU - Jiang,Xiaoqian, AU - Schulz,Paul E, PY - 2023/9/19/medline PY - 2023/8/14/pubmed PY - 2023/8/14/entrez KW - Alzheimer’s disease KW - cohort KW - dementia KW - diphtheria KW - epidemiology KW - herpes zoster KW - pertussis KW - pneumococcus KW - tetanus KW - vaccine SP - 703 EP - 718 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 95 IS - 2 N2 - BACKGROUND: Accumulating evidence suggests that adult vaccinations can reduce the risk of developing Alzheimer's disease (AD) and Alzheimer's disease related dementias. OBJECTIVE: To compare the risk for developing AD between adults with and without prior vaccination against tetanus and diphtheria, with or without pertussis (Tdap/Td); herpes zoster (HZ); or pneumococcus. METHODS: A retrospective cohort study was performed using Optum's de-identified Clinformatics® Data Mart Database. Included patients were free of dementia during a 2-year look-back period and were≥65 years old by the start of the 8-year follow-up period. We compared two similar cohorts identified using propensity score matching (PSM), one vaccinated and another unvaccinated, with Tdap/Td, HZ, or pneumococcal vaccines. We calculated the relative risk (RR) and absolute risk reduction (ARR) for developing AD. RESULTS: For the Tdap/Td vaccine, 7.2% (n = 8,370) of vaccinated patients and 10.2% (n = 11,857) of unvaccinated patients developed AD during follow-up; the RR was 0.70 (95% CI, 0.68-0.72) and ARR was 0.03 (95% CI, 0.02-0.03). For the HZ vaccine, 8.1% (n = 16,106) of vaccinated patients and 10.7% (n = 21,417) of unvaccinated patients developed AD during follow-up; the RR was 0.75 (95% CI, 0.73-0.76) and ARR was 0.02 (95% CI, 0.02-0.02). For the pneumococcal vaccine, 7.92% (n = 20,583) of vaccinated patients and 10.9% (n = 28,558) of unvaccinated patients developed AD during follow-up; the RR was 0.73 (95% CI, 0.71-0.74) and ARR was 0.02 (95% CI, 0.02-0.03). CONCLUSION: Several vaccinations, including Tdap/Td, HZ, and pneumococcal, are associated with a reduced risk for developing AD. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/37574727/full_citation DB - PRIME DP - Unbound Medicine ER -
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