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Frequency of illness associated with epidemic hepatitis A virus infections in adults.

Abstract

Hepatitis A virus infection is often described as mild or asymptomatic, particularly in children. The failure of most adults who are found to be immune to remember symptoms of an illness suggestive of hepatitis A virus supports this belief. In 1982, two large outbreaks occurred in well documented populations of military personnel. These outbreaks were each extensively studied epidemiologically and serologically. It was found that 28/29 (96.6%) hepatitis A infections recognized prior to immune serum globulin in Outbreak A and 35/46 (76.1%) infections in Outbreak A were symptomatic. Symptomatic cases failed to occur beyond eight days of immune serum globulin administration to these predominantly susceptible groups. Between 40 and 70% of patients were icteric. Apparent contrasts in symptoms associated with hepatitis A infection in adults and children suggest a basic age-dependent difference in immune response to such infection.

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  • Authors

    , , , , ,

    Source

    American journal of epidemiology 122:2 1985 Aug pg 226-33

    MeSH

    Adolescent
    Adult
    Age Factors
    Disease Outbreaks
    Epidemiologic Methods
    Germany, West
    Hepatitis A
    Histocompatibility Antigens Class II
    Humans
    Immunization, Passive
    Immunoglobulin M
    Kansas
    Male
    Middle Aged
    Military Medicine
    Radioimmunoassay

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    3860002

    Citation

    Lednar, W M., et al. "Frequency of Illness Associated With Epidemic Hepatitis a Virus Infections in Adults." American Journal of Epidemiology, vol. 122, no. 2, 1985, pp. 226-33.
    Lednar WM, Lemon SM, Kirkpatrick JW, et al. Frequency of illness associated with epidemic hepatitis A virus infections in adults. Am J Epidemiol. 1985;122(2):226-33.
    Lednar, W. M., Lemon, S. M., Kirkpatrick, J. W., Redfield, R. R., Fields, M. L., & Kelley, P. W. (1985). Frequency of illness associated with epidemic hepatitis A virus infections in adults. American Journal of Epidemiology, 122(2), pp. 226-33.
    Lednar WM, et al. Frequency of Illness Associated With Epidemic Hepatitis a Virus Infections in Adults. Am J Epidemiol. 1985;122(2):226-33. PubMed PMID: 3860002.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Frequency of illness associated with epidemic hepatitis A virus infections in adults. AU - Lednar,W M, AU - Lemon,S M, AU - Kirkpatrick,J W, AU - Redfield,R R, AU - Fields,M L, AU - Kelley,P W, PY - 1985/8/1/pubmed PY - 1985/8/1/medline PY - 1985/8/1/entrez SP - 226 EP - 33 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 122 IS - 2 N2 - Hepatitis A virus infection is often described as mild or asymptomatic, particularly in children. The failure of most adults who are found to be immune to remember symptoms of an illness suggestive of hepatitis A virus supports this belief. In 1982, two large outbreaks occurred in well documented populations of military personnel. These outbreaks were each extensively studied epidemiologically and serologically. It was found that 28/29 (96.6%) hepatitis A infections recognized prior to immune serum globulin in Outbreak A and 35/46 (76.1%) infections in Outbreak A were symptomatic. Symptomatic cases failed to occur beyond eight days of immune serum globulin administration to these predominantly susceptible groups. Between 40 and 70% of patients were icteric. Apparent contrasts in symptoms associated with hepatitis A infection in adults and children suggest a basic age-dependent difference in immune response to such infection. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/3860002/full_citation L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/oxfordjournals.aje.a114093 DB - PRIME DP - Unbound Medicine ER -