Iron accumulation/overload and Alzheimer's disease risk factors in the precuneus region: A comprehensive narrative review.
Aging Med (Milton). 2024 Oct; 7(5):649-667.AM

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease that is characterized by amyloid plaques, neurofibrillary tangles, and neuronal loss. Early cerebral and body iron dysregulation and accumulation interact with AD pathology, particularly in the precuneus, a crucial functional hub in cognitive functions. Quantitative susceptibility mapping (QSM), a novel post-processing approach, provides insights into tissue iron levels and cerebral oxygen metabolism and reveals abnormal iron accumulation early in AD. Increased iron deposition in the precuneus can lead to oxidative stress, neuroinflammation, and accelerated neurodegeneration. Metabolic disorders (diabetes, non-alcoholic fatty liver disease (NAFLD), and obesity), genetic factors, and small vessel pathology contribute to abnormal iron accumulation in the precuneus. Therefore, in line with the growing body of literature in the precuneus region of patients with AD, QSM as a neuroimaging method could serve as a non-invasive biomarker to track disease progression, complement other imaging modalities, and aid in early AD diagnosis and monitoring.

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Authors+Show Affiliations

Mohammadi S

Neuromuscular Research Center, Department of Neurology, Shariati Hospital Tehran University of Medical Sciences Tehran Iran.

Ghaderi S

Neuromuscular Research Center, Department of Neurology, Shariati Hospital Tehran University of Medical Sciences Tehran Iran. Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine Tehran University of Medical Sciences Tehran Iran.

Fatehi F

Neuromuscular Research Center, Department of Neurology, Shariati Hospital Tehran University of Medical Sciences Tehran Iran. Neurology Department University Hospitals of Leicester NHS Trust Leicester UK.

Pub Type(s)

Journal Article

Review

Language

eng

PubMed ID

39507230

Citation

Mohammadi, Sana, et al. "Iron Accumulation/overload and Alzheimer's Disease Risk Factors in the Precuneus Region: a Comprehensive Narrative Review." Aging Medicine (Milton (N.S.W)), vol. 7, no. 5, 2024, pp. 649-667.

Mohammadi S, Ghaderi S, Fatehi F. Iron accumulation/overload and Alzheimer's disease risk factors in the precuneus region: A comprehensive narrative review. Aging Med (Milton). 2024;7(5):649-667.

Mohammadi, S., Ghaderi, S., & Fatehi, F. (2024). Iron accumulation/overload and Alzheimer's disease risk factors in the precuneus region: A comprehensive narrative review. Aging Medicine (Milton (N.S.W)), 7(5), 649-667. https://doi.org/10.1002/agm2.12363

Mohammadi S, Ghaderi S, Fatehi F. Iron Accumulation/overload and Alzheimer's Disease Risk Factors in the Precuneus Region: a Comprehensive Narrative Review. Aging Med (Milton). 2024;7(5):649-667. PubMed PMID: 39507230.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Iron accumulation/overload and Alzheimer's disease risk factors in the precuneus region: A comprehensive narrative review. AU - Mohammadi,Sana, AU - Ghaderi,Sadegh, AU - Fatehi,Farzad, Y1 - 2024/10/22/ PY - 2024/06/14/received PY - 2024/09/25/accepted PY - 2024/11/12/medline PY - 2024/11/12/pubmed PY - 2024/11/7/entrez KW - Alzheimer's disease KW - iron KW - precuneus SP - 649 EP - 667 JF - Aging medicine (Milton (N.S.W)) JO - Aging Med (Milton) VL - 7 IS - 5 N2 - Alzheimer's disease (AD) is a neurodegenerative disease that is characterized by amyloid plaques, neurofibrillary tangles, and neuronal loss. Early cerebral and body iron dysregulation and accumulation interact with AD pathology, particularly in the precuneus, a crucial functional hub in cognitive functions. Quantitative susceptibility mapping (QSM), a novel post-processing approach, provides insights into tissue iron levels and cerebral oxygen metabolism and reveals abnormal iron accumulation early in AD. Increased iron deposition in the precuneus can lead to oxidative stress, neuroinflammation, and accelerated neurodegeneration. Metabolic disorders (diabetes, non-alcoholic fatty liver disease (NAFLD), and obesity), genetic factors, and small vessel pathology contribute to abnormal iron accumulation in the precuneus. Therefore, in line with the growing body of literature in the precuneus region of patients with AD, QSM as a neuroimaging method could serve as a non-invasive biomarker to track disease progression, complement other imaging modalities, and aid in early AD diagnosis and monitoring. SN - 2475-0360 UR - https://www.unboundmedicine.com/medline/citation/39507230/full_citation DB - PRIME DP - Unbound Medicine ER -

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Iron accumulation/overload and Alzheimer's disease risk factors in the precuneus region: A comprehensive narrative review.Aging Med (Milton). 2024 Oct; 7(5):649-667.AM