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Galactokinase activity in patients with idiopathic cataracts.

Abstract

Ninety-four consecutive patients admitted for elective cataract surgery were prospectively examined for erythrocyte galactokinase activity. The presumed etiology for the cataract was established by history and physical examination in 51 patients (21 were diabetic). The cataract was classified as idiopathic in 43 patients. Galactokinase activity was significantly lower in idiopathic vs. presumed (nondiabetic) etiology patients 50 years of age or younger (P less than 0.05) and in idiopathic cataract patients 50 years of age or younger vs. those older than 51 years of age (P = 0.0033). Three of the idiopathic cataract patients (6.9%) had galactokinase levels less than two standard deviations below the mean galactokinase level for age-matched patients with suspected (nondiabetic) etiology. Compared with the expected distribution for the heterozygote in the general population (0.2%), this was highly significant (P = 0.0001). Diminished galactokinase activity may increase the risk of developing presenile cataracts requiring surgery by the fourth decade.

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  • Publisher Full Text
  • Authors

    , ,

    Source

    Ophthalmology 93:2 1986 Feb pg 210-5

    MeSH

    Adult
    Aged
    Cataract
    Diabetes Complications
    Female
    Galactokinase
    Heterozygote
    Humans
    Male
    Middle Aged

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    3951827

    Citation

    Elman, M J., et al. "Galactokinase Activity in Patients With Idiopathic Cataracts." Ophthalmology, vol. 93, no. 2, 1986, pp. 210-5.
    Elman MJ, Miller MT, Matalon R. Galactokinase activity in patients with idiopathic cataracts. Ophthalmology. 1986;93(2):210-5.
    Elman, M. J., Miller, M. T., & Matalon, R. (1986). Galactokinase activity in patients with idiopathic cataracts. Ophthalmology, 93(2), pp. 210-5.
    Elman MJ, Miller MT, Matalon R. Galactokinase Activity in Patients With Idiopathic Cataracts. Ophthalmology. 1986;93(2):210-5. PubMed PMID: 3951827.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Galactokinase activity in patients with idiopathic cataracts. AU - Elman,M J, AU - Miller,M T, AU - Matalon,R, PY - 1986/2/1/pubmed PY - 1986/2/1/medline PY - 1986/2/1/entrez SP - 210 EP - 5 JF - Ophthalmology JO - Ophthalmology VL - 93 IS - 2 N2 - Ninety-four consecutive patients admitted for elective cataract surgery were prospectively examined for erythrocyte galactokinase activity. The presumed etiology for the cataract was established by history and physical examination in 51 patients (21 were diabetic). The cataract was classified as idiopathic in 43 patients. Galactokinase activity was significantly lower in idiopathic vs. presumed (nondiabetic) etiology patients 50 years of age or younger (P less than 0.05) and in idiopathic cataract patients 50 years of age or younger vs. those older than 51 years of age (P = 0.0033). Three of the idiopathic cataract patients (6.9%) had galactokinase levels less than two standard deviations below the mean galactokinase level for age-matched patients with suspected (nondiabetic) etiology. Compared with the expected distribution for the heterozygote in the general population (0.2%), this was highly significant (P = 0.0001). Diminished galactokinase activity may increase the risk of developing presenile cataracts requiring surgery by the fourth decade. SN - 0161-6420 UR - https://www.unboundmedicine.com/medline/citation/3951827/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(86)33761-8 DB - PRIME DP - Unbound Medicine ER -