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Galactokinase activity in patients with idiopathic cataracts.
Ophthalmology 1986; 93(2):210-5O

Abstract

Ninety-four consecutive patients admitted for elective cataract surgery were prospectively examined for erythrocyte galactokinase activity. The presumed etiology for the cataract was established by history and physical examination in 51 patients (21 were diabetic). The cataract was classified as idiopathic in 43 patients. Galactokinase activity was significantly lower in idiopathic vs. presumed (nondiabetic) etiology patients 50 years of age or younger (P less than 0.05) and in idiopathic cataract patients 50 years of age or younger vs. those older than 51 years of age (P = 0.0033). Three of the idiopathic cataract patients (6.9%) had galactokinase levels less than two standard deviations below the mean galactokinase level for age-matched patients with suspected (nondiabetic) etiology. Compared with the expected distribution for the heterozygote in the general population (0.2%), this was highly significant (P = 0.0001). Diminished galactokinase activity may increase the risk of developing presenile cataracts requiring surgery by the fourth decade.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3951827

Citation

Elman, M J., et al. "Galactokinase Activity in Patients With Idiopathic Cataracts." Ophthalmology, vol. 93, no. 2, 1986, pp. 210-5.
Elman MJ, Miller MT, Matalon R. Galactokinase activity in patients with idiopathic cataracts. Ophthalmology. 1986;93(2):210-5.
Elman, M. J., Miller, M. T., & Matalon, R. (1986). Galactokinase activity in patients with idiopathic cataracts. Ophthalmology, 93(2), pp. 210-5.
Elman MJ, Miller MT, Matalon R. Galactokinase Activity in Patients With Idiopathic Cataracts. Ophthalmology. 1986;93(2):210-5. PubMed PMID: 3951827.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Galactokinase activity in patients with idiopathic cataracts. AU - Elman,M J, AU - Miller,M T, AU - Matalon,R, PY - 1986/2/1/pubmed PY - 1986/2/1/medline PY - 1986/2/1/entrez SP - 210 EP - 5 JF - Ophthalmology JO - Ophthalmology VL - 93 IS - 2 N2 - Ninety-four consecutive patients admitted for elective cataract surgery were prospectively examined for erythrocyte galactokinase activity. The presumed etiology for the cataract was established by history and physical examination in 51 patients (21 were diabetic). The cataract was classified as idiopathic in 43 patients. Galactokinase activity was significantly lower in idiopathic vs. presumed (nondiabetic) etiology patients 50 years of age or younger (P less than 0.05) and in idiopathic cataract patients 50 years of age or younger vs. those older than 51 years of age (P = 0.0033). Three of the idiopathic cataract patients (6.9%) had galactokinase levels less than two standard deviations below the mean galactokinase level for age-matched patients with suspected (nondiabetic) etiology. Compared with the expected distribution for the heterozygote in the general population (0.2%), this was highly significant (P = 0.0001). Diminished galactokinase activity may increase the risk of developing presenile cataracts requiring surgery by the fourth decade. SN - 0161-6420 UR - https://www.unboundmedicine.com/medline/citation/3951827/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(86)33761-8 DB - PRIME DP - Unbound Medicine ER -