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A finite element model for biomechanical characterization of ex vivo peripheral nerve dysfunction during stretch.
Physiol Rep. 2024 Nov; 12(21):e70125.PR

Abstract

Peripheral nerve damage can cause debilitating symptoms ranging from numbness and pain to sensory loss and atrophy. To uncover the underlying mechanisms of peripheral nerve injury, our research aims to develop a relationship between biomechanical peripheral nerve damage and function through finite element modeling. A noncontact, ex vivo electrophysiology chamber, capable of axially stretching explanted nerves while recording electrical signals, was used to investigate peripheral nerve injury. Successive stretch trials were run on eight sciatic nerves (four females and four males) excised from Sprague-Dawley rats. Nerves were stretched until 50% compound action potential (CAP) amplitude reduction was obtained. A constitutive model developed by Raghavan and Vorp was suitable for rat sciatic nerves, with an average α and β of 0.183 MPa and 1.88 MPa, respectively. We then generated 95% confidence intervals for the stretch at which specific CAP amplitude reductions would occur, which compares well to previous studies. We also developed a finite element model that can predict stretch-induced signaling deficits, applicable for complex nerve geometries and injuries. This relationship between nerve biomechanics and function can be expanded upon to create a clinical model for peripheral nerve dysfunction due to stretch.

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Authors+Show Affiliations

Vasas NC
Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Forrest AM
Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Meyers NA
Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Christensen MB
Department of Otolaryngology - Head & Neck Surgery, University of Utah School of Medicine, Salt Lake City, Utah, USA. Division of Urology, Department of Surgery, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Pierce JL
Department of Otolaryngology - Head & Neck Surgery, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Kaufmann SM
Department of Otolaryngology - Head & Neck Surgery, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Lanaghen KB
Department of Otolaryngology - Head & Neck Surgery, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Paniello RC
Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Barkmeier-Kraemer JM
Department of Otolaryngology - Head & Neck Surgery, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Vande Geest JP
Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

MeSH

AnimalsRats, Sprague-DawleyFinite Element AnalysisSciatic NerveFemaleRatsMaleBiomechanical PhenomenaAction PotentialsPeripheral Nerve Injuries

Pub Type(s)

Journal Article

Language

eng

PubMed ID

39537361

Citation

Vasas, Nicholas C., et al. "A Finite Element Model for Biomechanical Characterization of Ex Vivo Peripheral Nerve Dysfunction During Stretch." Physiological Reports, vol. 12, no. 21, 2024, pp. e70125.
Vasas NC, Forrest AM, Meyers NA, et al. A finite element model for biomechanical characterization of ex vivo peripheral nerve dysfunction during stretch. Physiol Rep. 2024;12(21):e70125.
Vasas, N. C., Forrest, A. M., Meyers, N. A., Christensen, M. B., Pierce, J. L., Kaufmann, S. M., Lanaghen, K. B., Paniello, R. C., Barkmeier-Kraemer, J. M., & Vande Geest, J. P. (2024). A finite element model for biomechanical characterization of ex vivo peripheral nerve dysfunction during stretch. Physiological Reports, 12(21), e70125. https://doi.org/10.14814/phy2.70125
Vasas NC, et al. A Finite Element Model for Biomechanical Characterization of Ex Vivo Peripheral Nerve Dysfunction During Stretch. Physiol Rep. 2024;12(21):e70125. PubMed PMID: 39537361.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A finite element model for biomechanical characterization of ex vivo peripheral nerve dysfunction during stretch. AU - Vasas,Nicholas C, AU - Forrest,Adam M, AU - Meyers,Nathaniel A, AU - Christensen,Michael B, AU - Pierce,Jenny L, AU - Kaufmann,Sidney M, AU - Lanaghen,Kimberly B, AU - Paniello,Randal C, AU - Barkmeier-Kraemer,Julie M, AU - Vande Geest,Jonathan P, PY - 2024/11/01/revised PY - 2024/06/28/received PY - 2024/11/04/accepted PY - 2024/11/14/medline PY - 2024/11/14/pubmed PY - 2024/11/13/entrez KW - cauchy stress KW - compound action potential KW - finite element model KW - peripheral nerve damage KW - stretch SP - e70125 EP - e70125 JF - Physiological reports JO - Physiol Rep VL - 12 IS - 21 N2 - Peripheral nerve damage can cause debilitating symptoms ranging from numbness and pain to sensory loss and atrophy. To uncover the underlying mechanisms of peripheral nerve injury, our research aims to develop a relationship between biomechanical peripheral nerve damage and function through finite element modeling. A noncontact, ex vivo electrophysiology chamber, capable of axially stretching explanted nerves while recording electrical signals, was used to investigate peripheral nerve injury. Successive stretch trials were run on eight sciatic nerves (four females and four males) excised from Sprague-Dawley rats. Nerves were stretched until 50% compound action potential (CAP) amplitude reduction was obtained. A constitutive model developed by Raghavan and Vorp was suitable for rat sciatic nerves, with an average α and β of 0.183 MPa and 1.88 MPa, respectively. We then generated 95% confidence intervals for the stretch at which specific CAP amplitude reductions would occur, which compares well to previous studies. We also developed a finite element model that can predict stretch-induced signaling deficits, applicable for complex nerve geometries and injuries. This relationship between nerve biomechanics and function can be expanded upon to create a clinical model for peripheral nerve dysfunction due to stretch. SN - 2051-817X UR - https://www.unboundmedicine.com/medline/citation/39537361/A_finite_element_model_for_biomechanical_characterization_of_ex_vivo_peripheral_nerve_dysfunction_during_stretch DB - PRIME DP - Unbound Medicine ER -
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