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Food allergy and adult migraine: double-blind and mediator confirmation of an allergic etiology.
Ann Allergy 1985; 55(2):126-9AA

Abstract

Foods as a cause for migraine attacks were evaluated in 43 adults with recurrent migraine. Skin testing, elimination diets, double-blind challenges, and measurements of plasma histamine were performed. Thirteen subjects experienced 66% or greater reduction in headache frequency during a diet trial. Six subjects became headache free. Eleven of 16 skin test-positive patients responded to diet manipulation, while only two of 27 skin test-negatives did (P less than .005). Seven subjects agreed to double-blind challenges. In five of seven, at least one food provoked migraine. Placebo challenges did not provoke migraine. In three subjects, plasma histamine rose during migraine provoking challenges. The relationship between food ingestion and migraine is based in part on allergic mechanism. Tests for IgE-specific food allergy appear helpful in selecting patients likely to benefit from diet therapy.

Authors

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Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

4025956

Citation

Mansfield, L E., et al. "Food Allergy and Adult Migraine: Double-blind and Mediator Confirmation of an Allergic Etiology." Annals of Allergy, vol. 55, no. 2, 1985, pp. 126-9.
Mansfield LE, Vaughan TR, Waller SF, et al. Food allergy and adult migraine: double-blind and mediator confirmation of an allergic etiology. Ann Allergy. 1985;55(2):126-9.
Mansfield, L. E., Vaughan, T. R., Waller, S. F., Haverly, R. W., & Ting, S. (1985). Food allergy and adult migraine: double-blind and mediator confirmation of an allergic etiology. Annals of Allergy, 55(2), pp. 126-9.
Mansfield LE, et al. Food Allergy and Adult Migraine: Double-blind and Mediator Confirmation of an Allergic Etiology. Ann Allergy. 1985;55(2):126-9. PubMed PMID: 4025956.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Food allergy and adult migraine: double-blind and mediator confirmation of an allergic etiology. AU - Mansfield,L E, AU - Vaughan,T R, AU - Waller,S F, AU - Haverly,R W, AU - Ting,S, PY - 1985/8/1/pubmed PY - 1985/8/1/medline PY - 1985/8/1/entrez SP - 126 EP - 9 JF - Annals of allergy JO - Ann Allergy VL - 55 IS - 2 N2 - Foods as a cause for migraine attacks were evaluated in 43 adults with recurrent migraine. Skin testing, elimination diets, double-blind challenges, and measurements of plasma histamine were performed. Thirteen subjects experienced 66% or greater reduction in headache frequency during a diet trial. Six subjects became headache free. Eleven of 16 skin test-positive patients responded to diet manipulation, while only two of 27 skin test-negatives did (P less than .005). Seven subjects agreed to double-blind challenges. In five of seven, at least one food provoked migraine. Placebo challenges did not provoke migraine. In three subjects, plasma histamine rose during migraine provoking challenges. The relationship between food ingestion and migraine is based in part on allergic mechanism. Tests for IgE-specific food allergy appear helpful in selecting patients likely to benefit from diet therapy. SN - 0003-4738 UR - https://www.unboundmedicine.com/medline/citation/4025956/full_citation L2 - http://www.diseaseinfosearch.org/result/4811 DB - PRIME DP - Unbound Medicine ER -