Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections.
NPJ Vaccines. 2025 Jun 25; 10(1):130.NV

Abstract

AS01-adjuvanted shingles (herpes zoster) vaccination is associated with a lower risk of dementia, but the underlying mechanisms are unclear. In propensity-score matched cohort studies with 436,788 individuals, both the AS01-adjuvanted shingles and respiratory syncytial virus (RSV) vaccines, individually or combined, were associated with reduced 18-month risk of dementia. No difference was observed between the two AS01-adjuvanted vaccines, suggesting that the AS01 adjuvant itself plays a direct role in lowering dementia risk.

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Authors+Show Affiliations

Taquet M

Department of Psychiatry, University of Oxford, Oxford, UK. maxime.taquet@psych.ox.ac.uk. Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK. maxime.taquet@psych.ox.ac.uk.

Todd JA

Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Harrison PJ

Department of Psychiatry, University of Oxford, Oxford, UK. paul.harrison@psych.ox.ac.uk. Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK. paul.harrison@psych.ox.ac.uk.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

40562756

Citation

Taquet, Maxime, et al. "Lower Risk of Dementia With AS01-adjuvanted Vaccination Against Shingles and Respiratory Syncytial Virus Infections." NPJ Vaccines, vol. 10, no. 1, 2025, p. 130.

Taquet M, Todd JA, Harrison PJ. Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections. NPJ Vaccines. 2025;10(1):130.

Taquet, M., Todd, J. A., & Harrison, P. J. (2025). Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections. NPJ Vaccines, 10(1), 130. https://doi.org/10.1038/s41541-025-01172-3

Taquet M, Todd JA, Harrison PJ. Lower Risk of Dementia With AS01-adjuvanted Vaccination Against Shingles and Respiratory Syncytial Virus Infections. NPJ Vaccines. 2025 Jun 25;10(1):130. PubMed PMID: 40562756.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections. AU - Taquet,Maxime, AU - Todd,John A, AU - Harrison,Paul J, Y1 - 2025/06/25/ PY - 2025/02/19/received PY - 2025/05/23/accepted PY - 2025/6/26/medline PY - 2025/6/26/pubmed PY - 2025/6/25/entrez SP - 130 EP - 130 JF - NPJ vaccines JO - NPJ Vaccines VL - 10 IS - 1 N2 - AS01-adjuvanted shingles (herpes zoster) vaccination is associated with a lower risk of dementia, but the underlying mechanisms are unclear. In propensity-score matched cohort studies with 436,788 individuals, both the AS01-adjuvanted shingles and respiratory syncytial virus (RSV) vaccines, individually or combined, were associated with reduced 18-month risk of dementia. No difference was observed between the two AS01-adjuvanted vaccines, suggesting that the AS01 adjuvant itself plays a direct role in lowering dementia risk. SN - 2059-0105 UR - https://www.unboundmedicine.com/medline/citation/40562756/full_citation DB - PRIME DP - Unbound Medicine ER -

Tags

Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections.NPJ Vaccines. 2025 Jun 25; 10(1):130.NV