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Locally delivered simvastatin and rosuvastatin in the treatment of chronic periodontitis: A systematic review and meta-analysis.
Am J Dent. 2026 Jun; 39(3):125-133.AJ

Abstract

PURPOSE

This systematic review and meta-analysis evaluated the effectiveness of locally delivered simvastatin and rosuvastatin in the treatment of chronic periodontitis.

METHODS

A thorough literature review was performed utilizing PubMed, Scopus, Google Scholar, and ClinicalTrials.gov for studies published until June 2025. Titles, abstracts, and full texts of the eligible studies were obtained and reviewed. Data were subsequently extracted from the chosen studies and analyzed accordingly.

RESULTS

A total of 30 RCT studies with 1,211 participants were included. Our study showed that the local delivery of simvastatin and rosuvastatin significantly improved pocket depth [Weighted Mean Difference (WMD) 95% confidence interval (CI)] = -0.83, -1.31 respectively, P< 0.001), clinical attachment level (-1.20, -1.59, P< 0.001), gingival index (-0.60, -1.42, P< 0.001), modified sulcus bleeding index (-0.61, -0.36, P< 0.001), plaque index (-0.38, P< 0.001), and relative attachment level (-0.54, -0.89, P< 0.001). However, there was no significant association between the plaque index and the use of rosuvastatin (-0.20, P< 0.05).

CLINICAL SIGNIFICANCE

The local delivery of simvastatin and rosuvastatin along with scaling and root planing significantly reduced pocket depth and improved clinical attachment level, gingival index, modified sulcus bleeding index, and relative attachment level. Further clinical trials are still required to support the results of the current meta-analysis.

Authors+Show Affiliations

Zarei R
Islamic Azad University Pharmaceutical Sciences Branch, Tehran, Iran.
Vatankhah P
Student Research Committee, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
Chaparzade S
School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Ebrahimirad F
Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hassani P
Faculty of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Khamisi N
Student Research Committee, School of Dentistry, Islamic Azad University (Khorasgan Branch), Isfahan, Iran.
Dehzadeh S
Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Sezavar Z
Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Deravi N
School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran, niloofarderavi@sbmu.ac.ir.
Jahangiri S
Student Research Committee, School of Dentistry, Islamic Azad University (Khorasgan Branch), Isfahan, Iran.
Fakhimi Resaei H
Nakhchivan State University Faculty of Dentistry, Nakhchivan, Azerbaijan.
Khashayer Jafari A
School of Dentistry, Islamic Azad University of Tehran, Iran.
Mokhtari Sakhvidi A
Dental Faculty, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran, dralirezamokhtari95@gmail.com.

MeSH

HumansSimvastatinChronic PeriodontitisRosuvastatin CalciumHydroxymethylglutaryl-CoA Reductase Inhibitors

Pub Type(s)

Journal Article
Systematic Review
Meta-Analysis

Language

eng

PubMed ID

42247362

Citation

Zarei, Roza, et al. "Locally Delivered Simvastatin and Rosuvastatin in the Treatment of Chronic Periodontitis: a Systematic Review and Meta-analysis." American Journal of Dentistry, vol. 39, no. 3, 2026, pp. 125-133.
Zarei R, Vatankhah P, Chaparzade S, et al. Locally delivered simvastatin and rosuvastatin in the treatment of chronic periodontitis: A systematic review and meta-analysis. Am J Dent. 2026;39(3):125-133.
Zarei, R., Vatankhah, P., Chaparzade, S., Ebrahimirad, F., Hassani, P., Khamisi, N., Dehzadeh, S., Sezavar, Z., Deravi, N., Jahangiri, S., Fakhimi Resaei, H., Khashayer Jafari, A., & Mokhtari Sakhvidi, A. (2026). Locally delivered simvastatin and rosuvastatin in the treatment of chronic periodontitis: A systematic review and meta-analysis. American Journal of Dentistry, 39(3), 125-133.
Zarei R, et al. Locally Delivered Simvastatin and Rosuvastatin in the Treatment of Chronic Periodontitis: a Systematic Review and Meta-analysis. Am J Dent. 2026;39(3):125-133. PubMed PMID: 42247362.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Locally delivered simvastatin and rosuvastatin in the treatment of chronic periodontitis: A systematic review and meta-analysis. AU - Zarei,Roza, AU - Vatankhah,Pooya, AU - Chaparzade,Saman, AU - Ebrahimirad,Farbod, AU - Hassani,Pardis, AU - Khamisi,Nima, AU - Dehzadeh,Sahar, AU - Sezavar,Zahra, AU - Deravi,Niloofar, AU - Jahangiri,Sharare, AU - Fakhimi Resaei,Haleh, AU - Khashayer Jafari,Amir, AU - Mokhtari Sakhvidi,Alireza, PY - 2026/6/12/medline PY - 2026/6/5/pubmed PY - 2026/6/5/entrez SP - 125 EP - 133 JF - American journal of dentistry JO - Am J Dent VL - 39 IS - 3 N2 - PURPOSE: This systematic review and meta-analysis evaluated the effectiveness of locally delivered simvastatin and rosuvastatin in the treatment of chronic periodontitis. METHODS: A thorough literature review was performed utilizing PubMed, Scopus, Google Scholar, and ClinicalTrials.gov for studies published until June 2025. Titles, abstracts, and full texts of the eligible studies were obtained and reviewed. Data were subsequently extracted from the chosen studies and analyzed accordingly. RESULTS: A total of 30 RCT studies with 1,211 participants were included. Our study showed that the local delivery of simvastatin and rosuvastatin significantly improved pocket depth [Weighted Mean Difference (WMD) 95% confidence interval (CI)] = -0.83, -1.31 respectively, P< 0.001), clinical attachment level (-1.20, -1.59, P< 0.001), gingival index (-0.60, -1.42, P< 0.001), modified sulcus bleeding index (-0.61, -0.36, P< 0.001), plaque index (-0.38, P< 0.001), and relative attachment level (-0.54, -0.89, P< 0.001). However, there was no significant association between the plaque index and the use of rosuvastatin (-0.20, P< 0.05). CLINICAL SIGNIFICANCE: The local delivery of simvastatin and rosuvastatin along with scaling and root planing significantly reduced pocket depth and improved clinical attachment level, gingival index, modified sulcus bleeding index, and relative attachment level. Further clinical trials are still required to support the results of the current meta-analysis. SN - 0894-8275 UR - https://www.unboundmedicine.com/medline/citation/42247362/full_citation DB - PRIME DP - Unbound Medicine ER -

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