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Influence of delta infection on severity of hepatitis B.

Abstract

The prevalence of serum markers of primary delta infection was determined in 532 patients with acute benign hepatitis B seen in Italy, and in 111 patients with fulminant hepatitis B seen in Italy, France and England. Patients with fulminant hepatitis had significantly higher prevalence of delta markers (43/111, 39%) than did those with benign hepatitis (101/532, 19%). In 25 of the 43 patients with delta-positive fulminant hepatitis, serum markers indicated a primary hepatitis B infection while in the remaining 18, IgM antibody to hepatitis B core antigen was absent, indicating that hepatitis B preceded superinfection with the delta agent. The increased morbidity of HBsAg hepatitis with delta infection may result from the cumulative simultaneous exposure to hepatitis B virus and delta, or from superinfection of HBsAg carriers with delta.

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  • Authors

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    Source

    Lancet (London, England) 2:8305 1982 Oct 30 pg 945-7

    MeSH

    Acute Disease
    Carrier State
    Cytopathogenic Effect, Viral
    England
    France
    Hepatitis B
    Hepatitis B Antibodies
    Hepatitis B Antigens
    Hepatitis delta Antigens
    Humans
    Immunoglobulin M
    Italy
    Risk

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    6127458

    Citation

    Smedile, A, et al. "Influence of Delta Infection On Severity of Hepatitis B." Lancet (London, England), vol. 2, no. 8305, 1982, pp. 945-7.
    Smedile A, Farci P, Verme G, et al. Influence of delta infection on severity of hepatitis B. Lancet. 1982;2(8305):945-7.
    Smedile, A., Farci, P., Verme, G., Caredda, F., Cargnel, A., Caporaso, N., ... Rizzetto, M. (1982). Influence of delta infection on severity of hepatitis B. Lancet (London, England), 2(8305), pp. 945-7.
    Smedile A, et al. Influence of Delta Infection On Severity of Hepatitis B. Lancet. 1982 Oct 30;2(8305):945-7. PubMed PMID: 6127458.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Influence of delta infection on severity of hepatitis B. AU - Smedile,A, AU - Farci,P, AU - Verme,G, AU - Caredda,F, AU - Cargnel,A, AU - Caporaso,N, AU - Dentico,P, AU - Trepo,C, AU - Opolon,P, AU - Gimson,A, AU - Vergani,D, AU - Williams,R, AU - Rizzetto,M, PY - 1982/10/30/pubmed PY - 1982/10/30/medline PY - 1982/10/30/entrez SP - 945 EP - 7 JF - Lancet (London, England) JO - Lancet VL - 2 IS - 8305 N2 - The prevalence of serum markers of primary delta infection was determined in 532 patients with acute benign hepatitis B seen in Italy, and in 111 patients with fulminant hepatitis B seen in Italy, France and England. Patients with fulminant hepatitis had significantly higher prevalence of delta markers (43/111, 39%) than did those with benign hepatitis (101/532, 19%). In 25 of the 43 patients with delta-positive fulminant hepatitis, serum markers indicated a primary hepatitis B infection while in the remaining 18, IgM antibody to hepatitis B core antigen was absent, indicating that hepatitis B preceded superinfection with the delta agent. The increased morbidity of HBsAg hepatitis with delta infection may result from the cumulative simultaneous exposure to hepatitis B virus and delta, or from superinfection of HBsAg carriers with delta. SN - 0140-6736 UR - https://www.unboundmedicine.com/medline/citation/6127458/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(82)90156-8 DB - PRIME DP - Unbound Medicine ER -