Tags

Type your tag names separated by a space and hit enter

Epidemic non-A, non-B hepatitis in Nepal. Recovery of a possible etiologic agent and transmission studies in marmosets.
JAMA 1984; 252(22):3140-5JAMA

Abstract

An epidemic of non-A, non-B hepatitis occurred in Kathmandu Valley, Nepal, during 1981-1982, with approximately 7.6% of households and 1.4% of individuals affected. Cases occurred preponderantly in the 15- to 34-year-old age group (70%), with most cases (75%) occurring in males. A high mortality rate (21%) occurred in pregnant women admitted to the hospital. No single water source was implicated, but epidemic peaks occurred during monsoon rains, and multiple opportunities for enteric transmission existed. One of eight patient stools examined by immune electron microscopy revealed aggregated, antibody-coated, 27-nm viruslike particles when convalescent serum samples were used as sources of antibody. Inoculation of two chimpanzees and four marmosets with a suspension of this stool resulted in elevated liver enzyme activity in three marmosets. Fecal excretion of 27-nm particles during the acute phase of disease (with temporally coincident antigen activity by radioimmunoassay) was observed in one marmoset, which also developed convalescent antibody against the particles in the original inoculum.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6438353

Citation

Kane, M A., et al. "Epidemic non-A, non-B Hepatitis in Nepal. Recovery of a Possible Etiologic Agent and Transmission Studies in Marmosets." JAMA, vol. 252, no. 22, 1984, pp. 3140-5.
Kane MA, Bradley DW, Shrestha SM, et al. Epidemic non-A, non-B hepatitis in Nepal. Recovery of a possible etiologic agent and transmission studies in marmosets. JAMA. 1984;252(22):3140-5.
Kane, M. A., Bradley, D. W., Shrestha, S. M., Maynard, J. E., Cook, E. H., Mishra, R. P., & Joshi, D. D. (1984). Epidemic non-A, non-B hepatitis in Nepal. Recovery of a possible etiologic agent and transmission studies in marmosets. JAMA, 252(22), pp. 3140-5.
Kane MA, et al. Epidemic non-A, non-B Hepatitis in Nepal. Recovery of a Possible Etiologic Agent and Transmission Studies in Marmosets. JAMA. 1984 Dec 14;252(22):3140-5. PubMed PMID: 6438353.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemic non-A, non-B hepatitis in Nepal. Recovery of a possible etiologic agent and transmission studies in marmosets. AU - Kane,M A, AU - Bradley,D W, AU - Shrestha,S M, AU - Maynard,J E, AU - Cook,E H, AU - Mishra,R P, AU - Joshi,D D, PY - 1984/12/14/pubmed PY - 1984/12/14/medline PY - 1984/12/14/entrez SP - 3140 EP - 5 JF - JAMA JO - JAMA VL - 252 IS - 22 N2 - An epidemic of non-A, non-B hepatitis occurred in Kathmandu Valley, Nepal, during 1981-1982, with approximately 7.6% of households and 1.4% of individuals affected. Cases occurred preponderantly in the 15- to 34-year-old age group (70%), with most cases (75%) occurring in males. A high mortality rate (21%) occurred in pregnant women admitted to the hospital. No single water source was implicated, but epidemic peaks occurred during monsoon rains, and multiple opportunities for enteric transmission existed. One of eight patient stools examined by immune electron microscopy revealed aggregated, antibody-coated, 27-nm viruslike particles when convalescent serum samples were used as sources of antibody. Inoculation of two chimpanzees and four marmosets with a suspension of this stool resulted in elevated liver enzyme activity in three marmosets. Fecal excretion of 27-nm particles during the acute phase of disease (with temporally coincident antigen activity by radioimmunoassay) was observed in one marmoset, which also developed convalescent antibody against the particles in the original inoculum. SN - 0098-7484 UR - https://www.unboundmedicine.com/medline/citation/6438353/full_citation L2 - https://jamanetwork.com/journals/jama/fullarticle/vol/252/pg/3140 DB - PRIME DP - Unbound Medicine ER -