Inhibition of human estrogen synthetase (aromatase) by flavones.Science. 1984 Sep 07; 225(4666):1032-4.Sci
Abstract
Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes. These flavones include (in order of decreasing potency) 7,8-benzoflavone, chrysin, apigenin, flavone, flavanone, and quercetin; 5,6-benzoflavone was not inhibitory. 7,8-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement. Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism.
Links
MeSH
Pub Type(s)
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Language
eng
PubMed ID
6474163
Citation
Kellis, J T., and L E. Vickery. "Inhibition of Human Estrogen Synthetase (aromatase) By Flavones." Science (New York, N.Y.), vol. 225, no. 4666, 1984, pp. 1032-4.
Kellis JT, Vickery LE. Inhibition of human estrogen synthetase (aromatase) by flavones. Science. 1984;225(4666):1032-4.
Kellis, J. T., & Vickery, L. E. (1984). Inhibition of human estrogen synthetase (aromatase) by flavones. Science (New York, N.Y.), 225(4666), 1032-4.
Kellis JT, Vickery LE. Inhibition of Human Estrogen Synthetase (aromatase) By Flavones. Science. 1984 Sep 7;225(4666):1032-4. PubMed PMID: 6474163.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Inhibition of human estrogen synthetase (aromatase) by flavones.
AU - Kellis,J T,Jr
AU - Vickery,L E,
PY - 1984/9/7/pubmed
PY - 2001/3/28/medline
PY - 1984/9/7/entrez
SP - 1032
EP - 4
JF - Science (New York, N.Y.)
JO - Science
VL - 225
IS - 4666
N2 - Several naturally occurring and synthetic flavones were found to inhibit the aromatization of androstenedione and testosterone to estrogens catalyzed by human placental and ovarian microsomes. These flavones include (in order of decreasing potency) 7,8-benzoflavone, chrysin, apigenin, flavone, flavanone, and quercetin; 5,6-benzoflavone was not inhibitory. 7,8-Benzoflavone and chrysin were potent competitive inhibitors and induced spectral changes in the aromatase cytochrome P-450 indicative of substrate displacement. Flavones may thus compete with steroids in their interaction with certain monooxygenases and thereby alter steroid hormone metabolism.
SN - 0036-8075
UR - https://www.unboundmedicine.com/medline/citation/6474163/full_citation
L2 - https://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=6474163
DB - PRIME
DP - Unbound Medicine
ER -
