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Caffeine metabolism and coffee-attributed sleep disturbances.

Abstract

In six healthy subjects with a history of caffeine-induced wakefulness caffeine kinetics were compared to with those in six subjects not affected by caffeine. The data indicated that the former have a longer plasma t 1/2 (mean 7.4 and 4.2 hr) and slower plasma clearance (mean 1.2 and 1.7 ml . min-1 . kg-1) of caffeine. Plasma caffeine concentration at midnight, 8 hr after afternoon coffee, is higher in those with caffeine-attributed insomnia. Those reporting "coffee wakefulness" also tend to drink less coffee. We conclude that the rate of caffeine metabolism is a determinant of individual variation in the effect of drinking coffee on sleep.

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  • Publisher Full Text

    • Grapherence [↓5]

    Authors

    Levy M
    ,
    Zylber-Katz E

    Source

    MeSH

    Adult
    Caffeine
    Coffee
    Female
    Humans
    Kinetics
    Male
    Middle Aged
    Sleep Initiation and Maintenance Disorders
    Time Factors

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    6851408

    Citation

    Levy, M, and E Zylber-Katz. "Caffeine Metabolism and Coffee-attributed Sleep Disturbances." Clinical Pharmacology and Therapeutics, vol. 33, no. 6, 1983, pp. 770-5.
    Levy M, Zylber-Katz E. Caffeine metabolism and coffee-attributed sleep disturbances. Clin Pharmacol Ther. 1983;33(6):770-5.
    Levy, M., & Zylber-Katz, E. (1983). Caffeine metabolism and coffee-attributed sleep disturbances. Clinical Pharmacology and Therapeutics, 33(6), pp. 770-5.
    Levy M, Zylber-Katz E. Caffeine Metabolism and Coffee-attributed Sleep Disturbances. Clin Pharmacol Ther. 1983;33(6):770-5. PubMed PMID: 6851408.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Caffeine metabolism and coffee-attributed sleep disturbances. AU - Levy,M, AU - Zylber-Katz,E, PY - 1983/6/1/pubmed PY - 1983/6/1/medline PY - 1983/6/1/entrez SP - 770 EP - 5 JF - Clinical pharmacology and therapeutics JO - Clin. Pharmacol. Ther. VL - 33 IS - 6 N2 - In six healthy subjects with a history of caffeine-induced wakefulness caffeine kinetics were compared to with those in six subjects not affected by caffeine. The data indicated that the former have a longer plasma t 1/2 (mean 7.4 and 4.2 hr) and slower plasma clearance (mean 1.2 and 1.7 ml . min-1 . kg-1) of caffeine. Plasma caffeine concentration at midnight, 8 hr after afternoon coffee, is higher in those with caffeine-attributed insomnia. Those reporting "coffee wakefulness" also tend to drink less coffee. We conclude that the rate of caffeine metabolism is a determinant of individual variation in the effect of drinking coffee on sleep. SN - 0009-9236 UR - https://www.unboundmedicine.com/medline/citation/6851408/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0009-9236&date=1983&volume=33&issue=6&spage=770 DB - PRIME DP - Unbound Medicine ER -