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Caffeine metabolism and coffee-attributed sleep disturbances.

Abstract

In six healthy subjects with a history of caffeine-induced wakefulness caffeine kinetics were compared to with those in six subjects not affected by caffeine. The data indicated that the former have a longer plasma t 1/2 (mean 7.4 and 4.2 hr) and slower plasma clearance (mean 1.2 and 1.7 ml . min-1 . kg-1) of caffeine. Plasma caffeine concentration at midnight, 8 hr after afternoon coffee, is higher in those with caffeine-attributed insomnia. Those reporting "coffee wakefulness" also tend to drink less coffee. We conclude that the rate of caffeine metabolism is a determinant of individual variation in the effect of drinking coffee on sleep.

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    MeSH

    Adult
    Caffeine
    Coffee
    Female
    Humans
    Kinetics
    Male
    Middle Aged
    Sleep Initiation and Maintenance Disorders
    Time Factors

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    6851408

    Citation

    Levy, M, and E Zylber-Katz. "Caffeine Metabolism and Coffee-attributed Sleep Disturbances." Clinical Pharmacology and Therapeutics, vol. 33, no. 6, 1983, pp. 770-5.
    Levy M, Zylber-Katz E. Caffeine metabolism and coffee-attributed sleep disturbances. Clin Pharmacol Ther. 1983;33(6):770-5.
    Levy, M., & Zylber-Katz, E. (1983). Caffeine metabolism and coffee-attributed sleep disturbances. Clinical Pharmacology and Therapeutics, 33(6), pp. 770-5.
    Levy M, Zylber-Katz E. Caffeine Metabolism and Coffee-attributed Sleep Disturbances. Clin Pharmacol Ther. 1983;33(6):770-5. PubMed PMID: 6851408.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Caffeine metabolism and coffee-attributed sleep disturbances. AU - Levy,M, AU - Zylber-Katz,E, PY - 1983/6/1/pubmed PY - 1983/6/1/medline PY - 1983/6/1/entrez SP - 770 EP - 5 JF - Clinical pharmacology and therapeutics JO - Clin. Pharmacol. Ther. VL - 33 IS - 6 N2 - In six healthy subjects with a history of caffeine-induced wakefulness caffeine kinetics were compared to with those in six subjects not affected by caffeine. The data indicated that the former have a longer plasma t 1/2 (mean 7.4 and 4.2 hr) and slower plasma clearance (mean 1.2 and 1.7 ml . min-1 . kg-1) of caffeine. Plasma caffeine concentration at midnight, 8 hr after afternoon coffee, is higher in those with caffeine-attributed insomnia. Those reporting "coffee wakefulness" also tend to drink less coffee. We conclude that the rate of caffeine metabolism is a determinant of individual variation in the effect of drinking coffee on sleep. SN - 0009-9236 UR - https://www.unboundmedicine.com/medline/citation/6851408/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0009-9236&date=1983&volume=33&issue=6&spage=770 DB - PRIME DP - Unbound Medicine ER -