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Caffeine metabolism and coffee-attributed sleep disturbances.
Clin Pharmacol Ther 1983; 33(6):770-5CP

Abstract

In six healthy subjects with a history of caffeine-induced wakefulness caffeine kinetics were compared to with those in six subjects not affected by caffeine. The data indicated that the former have a longer plasma t 1/2 (mean 7.4 and 4.2 hr) and slower plasma clearance (mean 1.2 and 1.7 ml . min-1 . kg-1) of caffeine. Plasma caffeine concentration at midnight, 8 hr after afternoon coffee, is higher in those with caffeine-attributed insomnia. Those reporting "coffee wakefulness" also tend to drink less coffee. We conclude that the rate of caffeine metabolism is a determinant of individual variation in the effect of drinking coffee on sleep.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6851408

Citation

Levy, M, and E Zylber-Katz. "Caffeine Metabolism and Coffee-attributed Sleep Disturbances." Clinical Pharmacology and Therapeutics, vol. 33, no. 6, 1983, pp. 770-5.
Levy M, Zylber-Katz E. Caffeine metabolism and coffee-attributed sleep disturbances. Clin Pharmacol Ther. 1983;33(6):770-5.
Levy, M., & Zylber-Katz, E. (1983). Caffeine metabolism and coffee-attributed sleep disturbances. Clinical Pharmacology and Therapeutics, 33(6), pp. 770-5.
Levy M, Zylber-Katz E. Caffeine Metabolism and Coffee-attributed Sleep Disturbances. Clin Pharmacol Ther. 1983;33(6):770-5. PubMed PMID: 6851408.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Caffeine metabolism and coffee-attributed sleep disturbances. AU - Levy,M, AU - Zylber-Katz,E, PY - 1983/6/1/pubmed PY - 1983/6/1/medline PY - 1983/6/1/entrez SP - 770 EP - 5 JF - Clinical pharmacology and therapeutics JO - Clin. Pharmacol. Ther. VL - 33 IS - 6 N2 - In six healthy subjects with a history of caffeine-induced wakefulness caffeine kinetics were compared to with those in six subjects not affected by caffeine. The data indicated that the former have a longer plasma t 1/2 (mean 7.4 and 4.2 hr) and slower plasma clearance (mean 1.2 and 1.7 ml . min-1 . kg-1) of caffeine. Plasma caffeine concentration at midnight, 8 hr after afternoon coffee, is higher in those with caffeine-attributed insomnia. Those reporting "coffee wakefulness" also tend to drink less coffee. We conclude that the rate of caffeine metabolism is a determinant of individual variation in the effect of drinking coffee on sleep. SN - 0009-9236 UR - https://www.unboundmedicine.com/medline/citation/6851408/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0009-9236&date=1983&volume=33&issue=6&spage=770 DB - PRIME DP - Unbound Medicine ER -