Caffeine metabolism and coffee-attributed sleep disturbances.Clin Pharmacol Ther. 1983 Jun; 33(6):770-5.CP
Abstract
In six healthy subjects with a history of caffeine-induced wakefulness caffeine kinetics were compared to with those in six subjects not affected by caffeine. The data indicated that the former have a longer plasma t 1/2 (mean 7.4 and 4.2 hr) and slower plasma clearance (mean 1.2 and 1.7 ml . min-1 . kg-1) of caffeine. Plasma caffeine concentration at midnight, 8 hr after afternoon coffee, is higher in those with caffeine-attributed insomnia. Those reporting "coffee wakefulness" also tend to drink less coffee. We conclude that the rate of caffeine metabolism is a determinant of individual variation in the effect of drinking coffee on sleep.
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MeSH
Pub Type(s)
Journal Article
Language
eng
PubMed ID
6851408
Citation
Levy, M, and E Zylber-Katz. "Caffeine Metabolism and Coffee-attributed Sleep Disturbances." Clinical Pharmacology and Therapeutics, vol. 33, no. 6, 1983, pp. 770-5.
Levy M, Zylber-Katz E. Caffeine metabolism and coffee-attributed sleep disturbances. Clin Pharmacol Ther. 1983;33(6):770-5.
Levy, M., & Zylber-Katz, E. (1983). Caffeine metabolism and coffee-attributed sleep disturbances. Clinical Pharmacology and Therapeutics, 33(6), 770-5.
Levy M, Zylber-Katz E. Caffeine Metabolism and Coffee-attributed Sleep Disturbances. Clin Pharmacol Ther. 1983;33(6):770-5. PubMed PMID: 6851408.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Caffeine metabolism and coffee-attributed sleep disturbances.
AU - Levy,M,
AU - Zylber-Katz,E,
PY - 1983/6/1/pubmed
PY - 1983/6/1/medline
PY - 1983/6/1/entrez
SP - 770
EP - 5
JF - Clinical pharmacology and therapeutics
JO - Clin Pharmacol Ther
VL - 33
IS - 6
N2 - In six healthy subjects with a history of caffeine-induced wakefulness caffeine kinetics were compared to with those in six subjects not affected by caffeine. The data indicated that the former have a longer plasma t 1/2 (mean 7.4 and 4.2 hr) and slower plasma clearance (mean 1.2 and 1.7 ml . min-1 . kg-1) of caffeine. Plasma caffeine concentration at midnight, 8 hr after afternoon coffee, is higher in those with caffeine-attributed insomnia. Those reporting "coffee wakefulness" also tend to drink less coffee. We conclude that the rate of caffeine metabolism is a determinant of individual variation in the effect of drinking coffee on sleep.
SN - 0009-9236
UR - https://www.unboundmedicine.com/medline/citation/6851408/full_citation
L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0009-9236&date=1983&volume=33&issue=6&spage=770
DB - PRIME
DP - Unbound Medicine
ER -