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Immune complexes, complement, and anti-DNA in exacerbations of systemic lupus erythematosus (SLE).

Abstract

The usefulness of serological parameters in assessing clinical exacerbations of SLE was examined. Patients with active renal disease tend to have lower levels of CH50 and C3 and highest levels of immune complexes detected by C1qBA than those patients with extrarenal manifestations only. Patients with a combination of both active extrarenal and renal disease are more likely to demonstrate the lowest levels of CH50, C4, and C3. However, immune complex levels are not higher than levels detected in patients with only active nephritis. A normal C3 level argues against active nephritis. Low complement levels without appreciably elevated levels of C1qBA suggest that significant renal disease is unlikely. The serial measurements that best reflect evolving clinical activity and which may serve as markers of impending exacerbation are, in decreasing order of usefulness: C4, CH50, C1qBA, C4, C3 and ADA. However, a combination of CH50, C4, C3 and C1qBA appeared to be the most useful. Given various serologic changes, guidelines for following patients are offered.

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  • Authors

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    Source

    Medicine 60:3 1981 May pg 208-17

    MeSH

    Antibody-Dependent Cell Cytotoxicity
    Antigen-Antibody Complex
    Autoantibodies
    Complement C1
    Complement C3
    Complement C4
    Complement Fixation Tests
    Complement System Proteins
    DNA
    Female
    Humans
    Lupus Erythematosus, Systemic
    Male

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    7231154

    Citation

    Lloyd, W, and P H. Schur. "Immune Complexes, Complement, and anti-DNA in Exacerbations of Systemic Lupus Erythematosus (SLE)." Medicine, vol. 60, no. 3, 1981, pp. 208-17.
    Lloyd W, Schur PH. Immune complexes, complement, and anti-DNA in exacerbations of systemic lupus erythematosus (SLE). Medicine (Baltimore). 1981;60(3):208-17.
    Lloyd, W., & Schur, P. H. (1981). Immune complexes, complement, and anti-DNA in exacerbations of systemic lupus erythematosus (SLE). Medicine, 60(3), pp. 208-17.
    Lloyd W, Schur PH. Immune Complexes, Complement, and anti-DNA in Exacerbations of Systemic Lupus Erythematosus (SLE). Medicine (Baltimore). 1981;60(3):208-17. PubMed PMID: 7231154.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Immune complexes, complement, and anti-DNA in exacerbations of systemic lupus erythematosus (SLE). AU - Lloyd,W, AU - Schur,P H, PY - 1981/5/1/pubmed PY - 1981/5/1/medline PY - 1981/5/1/entrez SP - 208 EP - 17 JF - Medicine JO - Medicine (Baltimore) VL - 60 IS - 3 N2 - The usefulness of serological parameters in assessing clinical exacerbations of SLE was examined. Patients with active renal disease tend to have lower levels of CH50 and C3 and highest levels of immune complexes detected by C1qBA than those patients with extrarenal manifestations only. Patients with a combination of both active extrarenal and renal disease are more likely to demonstrate the lowest levels of CH50, C4, and C3. However, immune complex levels are not higher than levels detected in patients with only active nephritis. A normal C3 level argues against active nephritis. Low complement levels without appreciably elevated levels of C1qBA suggest that significant renal disease is unlikely. The serial measurements that best reflect evolving clinical activity and which may serve as markers of impending exacerbation are, in decreasing order of usefulness: C4, CH50, C1qBA, C4, C3 and ADA. However, a combination of CH50, C4, C3 and C1qBA appeared to be the most useful. Given various serologic changes, guidelines for following patients are offered. SN - 0025-7974 UR - https://www.unboundmedicine.com/medline/citation/7231154/full_citation L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=7231154.ui DB - PRIME DP - Unbound Medicine ER -