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Infection with the delta agent in chronic HBsAg carriers.

Abstract

To establish the mechanism of progression to chronicity of the HBsAg-associated delta infection, serum hepatitis B virus and delta markers were tested in five babies born to HBsAg-positive mothers with anti-delta, in 42 follow-up patients with acute hepatitis B virus and delta hepatitis, and in collections of sera from 8 HBsAg carriers with anti-delta. Evidence of delta infection was found in the baby born to a mother with serum HBeAg and in none of the four babies born to mothers with anti-HBe. Hepatitis was self-limited in the 42 patients acutely infected by hepatitis B virus and delta agent; none developed persistent HBs-antigenemia and the majority displayed transient anti-delta of IgM class. In seven HBsAg carriers high titers of anti-delta developed during the follow-up; coincident with the rise of the antibody, aminotransferase elevation occurred in five previously asymptomatic carriers and persisted in three of them. No sign of infectious hepatitis B virus replication was detected in five of the carriers throughout the follow-up, and all of them had anti-HBe before the rise of anti-delta and of aminotransferase. HBsAg carriers with diminished hepatitis B virus synthesis appear to be at high risk of developing chronic delta infection and disease when exposed to the delta-infectious serum of other carriers.

Authors

, , , , , ,

Source

Gastroenterology 81:6 1981 Dec pg 992-7

MeSH

Adult
Antibodies
Carrier State
Chronic Disease
Female
Hepatitis B
Hepatitis B Antigens
Hepatitis B Surface Antigens
Hepatitis B virus
Hepatitis delta Antigens
Humans
Infant, Newborn
Male
Pregnancy
Prenatal Exposure Delayed Effects
Prospective Studies
Retrospective Studies

Pub Type(s)

Journal Article

Language

eng

PubMed ID

7286594

Citation

Smedile, A, et al. "Infection With the Delta Agent in Chronic HBsAg Carriers." Gastroenterology, vol. 81, no. 6, 1981, pp. 992-7.
Smedile A, Dentico P, Zanetti A, et al. Infection with the delta agent in chronic HBsAg carriers. Gastroenterology. 1981;81(6):992-7.
Smedile, A., Dentico, P., Zanetti, A., Sagnelli, E., Nordenfelt, E., Actis, G. C., & Rizzetto, M. (1981). Infection with the delta agent in chronic HBsAg carriers. Gastroenterology, 81(6), pp. 992-7.
Smedile A, et al. Infection With the Delta Agent in Chronic HBsAg Carriers. Gastroenterology. 1981;81(6):992-7. PubMed PMID: 7286594.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Infection with the delta agent in chronic HBsAg carriers. AU - Smedile,A, AU - Dentico,P, AU - Zanetti,A, AU - Sagnelli,E, AU - Nordenfelt,E, AU - Actis,G C, AU - Rizzetto,M, PY - 1981/12/1/pubmed PY - 1981/12/1/medline PY - 1981/12/1/entrez SP - 992 EP - 7 JF - Gastroenterology JO - Gastroenterology VL - 81 IS - 6 N2 - To establish the mechanism of progression to chronicity of the HBsAg-associated delta infection, serum hepatitis B virus and delta markers were tested in five babies born to HBsAg-positive mothers with anti-delta, in 42 follow-up patients with acute hepatitis B virus and delta hepatitis, and in collections of sera from 8 HBsAg carriers with anti-delta. Evidence of delta infection was found in the baby born to a mother with serum HBeAg and in none of the four babies born to mothers with anti-HBe. Hepatitis was self-limited in the 42 patients acutely infected by hepatitis B virus and delta agent; none developed persistent HBs-antigenemia and the majority displayed transient anti-delta of IgM class. In seven HBsAg carriers high titers of anti-delta developed during the follow-up; coincident with the rise of the antibody, aminotransferase elevation occurred in five previously asymptomatic carriers and persisted in three of them. No sign of infectious hepatitis B virus replication was detected in five of the carriers throughout the follow-up, and all of them had anti-HBe before the rise of anti-delta and of aminotransferase. HBsAg carriers with diminished hepatitis B virus synthesis appear to be at high risk of developing chronic delta infection and disease when exposed to the delta-infectious serum of other carriers. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/7286594/full_citation L2 - https://medlineplus.gov/hepatitisb.html DB - PRIME DP - Unbound Medicine ER -