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Occult caffeine as a source of sleep problems in an older population.

Abstract

OBJECTIVE

To evaluate the impact of caffeine in medication on sleep complaints in a community population of persons aged 67 or older.

DESIGN

Cross-sectional analysis.

SETTING

Iowa 65+ Rural Health Study.

PARTICIPANTS

Those who completed their own interview, including a section on the use of medications, during the third annual in-person follow-up in 1984-1985.

MEASUREMENTS

MAIN OUTCOMES

trouble falling asleep or other sleep complaints. Covariates: use of caffeine-containing medication, spasmolytic, or sympathomimetic drug; number of drugs used; depressive symptoms; self-perceived health; comorbidity, hip fracture, arthritis, ulcer of stomach or intestines; and consumption of caffeinated beverages.

RESULTS

The prevalence of caffeinated medication use by participants was 5.4%. Those reporting the use of any caffeine-containing medication were at an increased risk of having trouble falling asleep (Odds Ratio [OR] = 1.79, 95% confidence interval [CI] = 1.19-2.68). There was no significant risk of other reported nighttime or daytime sleep problems associated with use of caffeine-containing drugs. Even after adjusting for other factors that could interfere with initiation of sleep, such as painful disease, depressive symptoms, polypharmacy, use of specific medications known to interfere with sleep, and coffee consumption, the use of caffeine-containing medication still presented a significantly increased risk of having trouble falling asleep (OR = 1.60, CI = 1.04-2.46). Although those participants using over-the-counter analgesic medication containing caffeine had an increased risk of trouble falling asleep (OR = 1.88, CI = 1.22-2.90), there was no significant risk of trouble falling asleep for those who took similar noncaffeinated OTC analgesic drugs (OR = 1.26, CI = 0.87-1.83).

CONCLUSIONS

The use of caffeine-containing medication is associated with sleep problems. Healthcare providers should be aware of potential problems associated with over-the-counter medications containing caffeine and should counsel patients about the potential of sleep problems. Older patients should be encouraged to read the label on medications and to select drugs that are caffeine-free when that is possible.

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  • Authors+Show Affiliations

    ,

    Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, Maryland, USA.

    , , , , , ,

    Source

    MeSH

    Aged
    Caffeine
    Cross-Sectional Studies
    Diet Surveys
    Drug-Related Side Effects and Adverse Reactions
    Female
    Follow-Up Studies
    Humans
    Iowa
    Logistic Models
    Male
    Rural Health
    Sleep Wake Disorders
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    7636092

    Citation

    Brown, S L., et al. "Occult Caffeine as a Source of Sleep Problems in an Older Population." Journal of the American Geriatrics Society, vol. 43, no. 8, 1995, pp. 860-4.
    Brown SL, Salive ME, Pahor M, et al. Occult caffeine as a source of sleep problems in an older population. J Am Geriatr Soc. 1995;43(8):860-4.
    Brown, S. L., Salive, M. E., Pahor, M., Foley, D. J., Corti, M. C., Langlois, J. A., ... Harris, T. B. (1995). Occult caffeine as a source of sleep problems in an older population. Journal of the American Geriatrics Society, 43(8), pp. 860-4.
    Brown SL, et al. Occult Caffeine as a Source of Sleep Problems in an Older Population. J Am Geriatr Soc. 1995;43(8):860-4. PubMed PMID: 7636092.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Occult caffeine as a source of sleep problems in an older population. AU - Brown,S L, AU - Salive,M E, AU - Pahor,M, AU - Foley,D J, AU - Corti,M C, AU - Langlois,J A, AU - Wallace,R B, AU - Harris,T B, PY - 1995/8/1/pubmed PY - 1995/8/1/medline PY - 1995/8/1/entrez SP - 860 EP - 4 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 43 IS - 8 N2 - OBJECTIVE: To evaluate the impact of caffeine in medication on sleep complaints in a community population of persons aged 67 or older. DESIGN: Cross-sectional analysis. SETTING: Iowa 65+ Rural Health Study. PARTICIPANTS: Those who completed their own interview, including a section on the use of medications, during the third annual in-person follow-up in 1984-1985. MEASUREMENTS: MAIN OUTCOMES: trouble falling asleep or other sleep complaints. Covariates: use of caffeine-containing medication, spasmolytic, or sympathomimetic drug; number of drugs used; depressive symptoms; self-perceived health; comorbidity, hip fracture, arthritis, ulcer of stomach or intestines; and consumption of caffeinated beverages. RESULTS: The prevalence of caffeinated medication use by participants was 5.4%. Those reporting the use of any caffeine-containing medication were at an increased risk of having trouble falling asleep (Odds Ratio [OR] = 1.79, 95% confidence interval [CI] = 1.19-2.68). There was no significant risk of other reported nighttime or daytime sleep problems associated with use of caffeine-containing drugs. Even after adjusting for other factors that could interfere with initiation of sleep, such as painful disease, depressive symptoms, polypharmacy, use of specific medications known to interfere with sleep, and coffee consumption, the use of caffeine-containing medication still presented a significantly increased risk of having trouble falling asleep (OR = 1.60, CI = 1.04-2.46). Although those participants using over-the-counter analgesic medication containing caffeine had an increased risk of trouble falling asleep (OR = 1.88, CI = 1.22-2.90), there was no significant risk of trouble falling asleep for those who took similar noncaffeinated OTC analgesic drugs (OR = 1.26, CI = 0.87-1.83). CONCLUSIONS: The use of caffeine-containing medication is associated with sleep problems. Healthcare providers should be aware of potential problems associated with over-the-counter medications containing caffeine and should counsel patients about the potential of sleep problems. Older patients should be encouraged to read the label on medications and to select drugs that are caffeine-free when that is possible. SN - 0002-8614 UR - https://www.unboundmedicine.com/medline/citation/7636092/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0002-8614&date=1995&volume=43&issue=8&spage=860 DB - PRIME DP - Unbound Medicine ER -