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Drugs recently associated with lupus syndromes.

Abstract

A number of drugs have recently been implicated in a syndrome that resembles systemic lupus erythematosus. One of the difficulties in many of these patients is that the signs, symptoms and serological abnormalities reported in these patients may be a natural consequence of the primary diseases rather than the incriminated drug. A second problem with the studies is a lack of uniform reporting of the techniques used to detect autoantibodies. For example, a patient that has a highly positive ANA with a homogeneous pattern of staining or a positive LE cell test usually has antibodies directed against chromatin components (DNA, histones, high mobility group (HMG) proteins). The discrepancies in clinical criteria and the serological techniques in many of these reports, emphasize the importance of using guidelines for the diagnosis of drug-induced or drug-related lupus. In the future, it appears that the increased use of biological response modifiers such as interferon-alpha and other cytokines may prompt more reports of lupus syndromes associated with their use.

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  • Publisher Full Text
  • Authors+Show Affiliations

    Faculty of Medicine, University of Calgary, AB Canada.

    Source

    Lupus 3:6 1994 Dec pg 455-9

    MeSH

    Deferiprone
    Humans
    Interferon-alpha
    Interleukin-2
    Leuprolide
    Lupus Erythematosus, Systemic
    Penicillamine
    Pyridones
    Sulfasalazine
    Valproic Acid

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    7704001

    Citation

    Fritzler, M J.. "Drugs Recently Associated With Lupus Syndromes." Lupus, vol. 3, no. 6, 1994, pp. 455-9.
    Fritzler MJ. Drugs recently associated with lupus syndromes. Lupus. 1994;3(6):455-9.
    Fritzler, M. J. (1994). Drugs recently associated with lupus syndromes. Lupus, 3(6), pp. 455-9.
    Fritzler MJ. Drugs Recently Associated With Lupus Syndromes. Lupus. 1994;3(6):455-9. PubMed PMID: 7704001.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Drugs recently associated with lupus syndromes. A1 - Fritzler,M J, PY - 1994/12/1/pubmed PY - 1994/12/1/medline PY - 1994/12/1/entrez SP - 455 EP - 9 JF - Lupus JO - Lupus VL - 3 IS - 6 N2 - A number of drugs have recently been implicated in a syndrome that resembles systemic lupus erythematosus. One of the difficulties in many of these patients is that the signs, symptoms and serological abnormalities reported in these patients may be a natural consequence of the primary diseases rather than the incriminated drug. A second problem with the studies is a lack of uniform reporting of the techniques used to detect autoantibodies. For example, a patient that has a highly positive ANA with a homogeneous pattern of staining or a positive LE cell test usually has antibodies directed against chromatin components (DNA, histones, high mobility group (HMG) proteins). The discrepancies in clinical criteria and the serological techniques in many of these reports, emphasize the importance of using guidelines for the diagnosis of drug-induced or drug-related lupus. In the future, it appears that the increased use of biological response modifiers such as interferon-alpha and other cytokines may prompt more reports of lupus syndromes associated with their use. SN - 0961-2033 UR - https://www.unboundmedicine.com/medline/citation/7704001/full_citation L2 - http://journals.sagepub.com/doi/full/10.1177/096120339400300605?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -