TY - JOUR T1 - Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder. AU - Benjamin,J, AU - Levine,J, AU - Fux,M, AU - Aviv,A, AU - Levy,D, AU - Belmaker,R H, PY - 1995/7/1/pubmed PY - 1995/7/1/medline PY - 1995/7/1/entrez SP - 1084 EP - 6 JF - The American journal of psychiatry JO - Am J Psychiatry VL - 152 IS - 7 N2 - OBJECTIVE: Because they found in an earlier study that inositol, an important intracellular second-messenger precursor, was effective against depression in open and double-blind trials, the authors studied its effectiveness against panic disorder. METHOD: Twenty-one patients with panic disorder with or without agoraphobia completed a double-blind, placebo-controlled, 4-week, random-assignment crossover treatment trial of 12 g/day of inositol. RESULTS: The frequency and severity of panic attacks and the severity of agoraphobia declined significantly more after inositol than after placebo administration. Side effects were minimal. CONCLUSIONS: The authors conclude that inositol's efficacy, the absence of significant side effects, and the fact that inositol is a natural component of the human diet make it a potentially attractive therapeutic for panic disorder. SN - 0002-953X UR - https://www.unboundmedicine.com/medline/citation/7793450/full_citation L2 - https://ajp.psychiatryonline.org/doi/10.1176/ajp.152.7.1084?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -