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Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder.

Abstract

OBJECTIVE

Because they found in an earlier study that inositol, an important intracellular second-messenger precursor, was effective against depression in open and double-blind trials, the authors studied its effectiveness against panic disorder.

METHOD

Twenty-one patients with panic disorder with or without agoraphobia completed a double-blind, placebo-controlled, 4-week, random-assignment crossover treatment trial of 12 g/day of inositol.

RESULTS

The frequency and severity of panic attacks and the severity of agoraphobia declined significantly more after inositol than after placebo administration. Side effects were minimal.

CONCLUSIONS

The authors conclude that inositol's efficacy, the absence of significant side effects, and the fact that inositol is a natural component of the human diet make it a potentially attractive therapeutic for panic disorder.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Soroka Medical Center, Kupat Holim Sick Fund of the Histadrut, Beersheba, Israel.

    , , , ,

    Source

    The American journal of psychiatry 152:7 1995 Jul pg 1084-6

    MeSH

    Adult
    Agoraphobia
    Cross-Over Studies
    Double-Blind Method
    Female
    Humans
    Inositol
    Male
    Panic Disorder
    Placebos
    Severity of Illness Index
    Treatment Outcome

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    7793450

    Citation

    Benjamin, J, et al. "Double-blind, Placebo-controlled, Crossover Trial of Inositol Treatment for Panic Disorder." The American Journal of Psychiatry, vol. 152, no. 7, 1995, pp. 1084-6.
    Benjamin J, Levine J, Fux M, et al. Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder. Am J Psychiatry. 1995;152(7):1084-6.
    Benjamin, J., Levine, J., Fux, M., Aviv, A., Levy, D., & Belmaker, R. H. (1995). Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder. The American Journal of Psychiatry, 152(7), pp. 1084-6.
    Benjamin J, et al. Double-blind, Placebo-controlled, Crossover Trial of Inositol Treatment for Panic Disorder. Am J Psychiatry. 1995;152(7):1084-6. PubMed PMID: 7793450.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder. AU - Benjamin,J, AU - Levine,J, AU - Fux,M, AU - Aviv,A, AU - Levy,D, AU - Belmaker,R H, PY - 1995/7/1/pubmed PY - 1995/7/1/medline PY - 1995/7/1/entrez SP - 1084 EP - 6 JF - The American journal of psychiatry JO - Am J Psychiatry VL - 152 IS - 7 N2 - OBJECTIVE: Because they found in an earlier study that inositol, an important intracellular second-messenger precursor, was effective against depression in open and double-blind trials, the authors studied its effectiveness against panic disorder. METHOD: Twenty-one patients with panic disorder with or without agoraphobia completed a double-blind, placebo-controlled, 4-week, random-assignment crossover treatment trial of 12 g/day of inositol. RESULTS: The frequency and severity of panic attacks and the severity of agoraphobia declined significantly more after inositol than after placebo administration. Side effects were minimal. CONCLUSIONS: The authors conclude that inositol's efficacy, the absence of significant side effects, and the fact that inositol is a natural component of the human diet make it a potentially attractive therapeutic for panic disorder. SN - 0002-953X UR - https://www.unboundmedicine.com/medline/citation/7793450/full_citation L2 - https://ajp.psychiatryonline.org/doi/full/10.1176/ajp.152.7.1084?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -