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Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder.
Am J Psychiatry 1995; 152(7):1084-6AJ

Abstract

OBJECTIVE

Because they found in an earlier study that inositol, an important intracellular second-messenger precursor, was effective against depression in open and double-blind trials, the authors studied its effectiveness against panic disorder.

METHOD

Twenty-one patients with panic disorder with or without agoraphobia completed a double-blind, placebo-controlled, 4-week, random-assignment crossover treatment trial of 12 g/day of inositol.

RESULTS

The frequency and severity of panic attacks and the severity of agoraphobia declined significantly more after inositol than after placebo administration. Side effects were minimal.

CONCLUSIONS

The authors conclude that inositol's efficacy, the absence of significant side effects, and the fact that inositol is a natural component of the human diet make it a potentially attractive therapeutic for panic disorder.

Authors+Show Affiliations

Soroka Medical Center, Kupat Holim Sick Fund of the Histadrut, Beersheba, Israel.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

7793450

Citation

Benjamin, J, et al. "Double-blind, Placebo-controlled, Crossover Trial of Inositol Treatment for Panic Disorder." The American Journal of Psychiatry, vol. 152, no. 7, 1995, pp. 1084-6.
Benjamin J, Levine J, Fux M, et al. Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder. Am J Psychiatry. 1995;152(7):1084-6.
Benjamin, J., Levine, J., Fux, M., Aviv, A., Levy, D., & Belmaker, R. H. (1995). Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder. The American Journal of Psychiatry, 152(7), pp. 1084-6.
Benjamin J, et al. Double-blind, Placebo-controlled, Crossover Trial of Inositol Treatment for Panic Disorder. Am J Psychiatry. 1995;152(7):1084-6. PubMed PMID: 7793450.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder. AU - Benjamin,J, AU - Levine,J, AU - Fux,M, AU - Aviv,A, AU - Levy,D, AU - Belmaker,R H, PY - 1995/7/1/pubmed PY - 1995/7/1/medline PY - 1995/7/1/entrez SP - 1084 EP - 6 JF - The American journal of psychiatry JO - Am J Psychiatry VL - 152 IS - 7 N2 - OBJECTIVE: Because they found in an earlier study that inositol, an important intracellular second-messenger precursor, was effective against depression in open and double-blind trials, the authors studied its effectiveness against panic disorder. METHOD: Twenty-one patients with panic disorder with or without agoraphobia completed a double-blind, placebo-controlled, 4-week, random-assignment crossover treatment trial of 12 g/day of inositol. RESULTS: The frequency and severity of panic attacks and the severity of agoraphobia declined significantly more after inositol than after placebo administration. Side effects were minimal. CONCLUSIONS: The authors conclude that inositol's efficacy, the absence of significant side effects, and the fact that inositol is a natural component of the human diet make it a potentially attractive therapeutic for panic disorder. SN - 0002-953X UR - https://www.unboundmedicine.com/medline/citation/7793450/full_citation L2 - https://ajp.psychiatryonline.org/doi/full/10.1176/ajp.152.7.1084?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -