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The effect of dietary fat and fiber on serum estrogen concentrations in premenopausal women under controlled dietary conditions.

Abstract

The effect of dietary fiber and fat on serum sex hormones was studied in premenopausal women. After an initial control period during which the diet was high in fat (40% of calories as fat) and low in fiber (12 g/day), the amounts of fat and fiber were varied in the setting of a metabolic kitchen and carefully monitored meals. Forty-eight women completed 58 protocols. When the diet was changed to low-fat (20-25% calories as fat) and high fiber (40 g/day), there were significant decreases in serum concentrations of estrone, estrone sulfate, testosterone, androstenedione, and sex hormone binding globulin (SHBG) and near significant decreases in estradiol and free estradiol. When independent effects were examined, high fiber alone caused a decrease in estradiol and SHBG, whereas fat and fiber caused the observed decrease in estrone sulfate. Dietary fat independently influenced the serum concentration of androstenedione. Increased dietary fiber caused a lengthening of the menstrual cycle by 0.72 day and a lengthening of the follicular phase by 0.85 day.

Authors+Show Affiliations

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Department of Community Health, Tufts University School of Medicine, Medford, MA 02111.

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Source

Cancer 74:3 Suppl 1994 Aug 01 pg 1125-31

MeSH

Adult
Androstenedione
Dietary Fats
Dietary Fiber
Estrogens
Estrone
Female
Humans
Menstrual Cycle
Sex Hormone-Binding Globulin
Testosterone

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8039147

Citation

Goldin, B R., et al. "The Effect of Dietary Fat and Fiber On Serum Estrogen Concentrations in Premenopausal Women Under Controlled Dietary Conditions." Cancer, vol. 74, no. 3 Suppl, 1994, pp. 1125-31.
Goldin BR, Woods MN, Spiegelman DL, et al. The effect of dietary fat and fiber on serum estrogen concentrations in premenopausal women under controlled dietary conditions. Cancer. 1994;74(3 Suppl):1125-31.
Goldin, B. R., Woods, M. N., Spiegelman, D. L., Longcope, C., Morrill-LaBrode, A., Dwyer, J. T., ... Gorbach, S. L. (1994). The effect of dietary fat and fiber on serum estrogen concentrations in premenopausal women under controlled dietary conditions. Cancer, 74(3 Suppl), pp. 1125-31.
Goldin BR, et al. The Effect of Dietary Fat and Fiber On Serum Estrogen Concentrations in Premenopausal Women Under Controlled Dietary Conditions. Cancer. 1994 Aug 1;74(3 Suppl):1125-31. PubMed PMID: 8039147.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of dietary fat and fiber on serum estrogen concentrations in premenopausal women under controlled dietary conditions. AU - Goldin,B R, AU - Woods,M N, AU - Spiegelman,D L, AU - Longcope,C, AU - Morrill-LaBrode,A, AU - Dwyer,J T, AU - Gualtieri,L J, AU - Hertzmark,E, AU - Gorbach,S L, PY - 1994/8/1/pubmed PY - 1994/8/1/medline PY - 1994/8/1/entrez SP - 1125 EP - 31 JF - Cancer JO - Cancer VL - 74 IS - 3 Suppl N2 - The effect of dietary fiber and fat on serum sex hormones was studied in premenopausal women. After an initial control period during which the diet was high in fat (40% of calories as fat) and low in fiber (12 g/day), the amounts of fat and fiber were varied in the setting of a metabolic kitchen and carefully monitored meals. Forty-eight women completed 58 protocols. When the diet was changed to low-fat (20-25% calories as fat) and high fiber (40 g/day), there were significant decreases in serum concentrations of estrone, estrone sulfate, testosterone, androstenedione, and sex hormone binding globulin (SHBG) and near significant decreases in estradiol and free estradiol. When independent effects were examined, high fiber alone caused a decrease in estradiol and SHBG, whereas fat and fiber caused the observed decrease in estrone sulfate. Dietary fat independently influenced the serum concentration of androstenedione. Increased dietary fiber caused a lengthening of the menstrual cycle by 0.72 day and a lengthening of the follicular phase by 0.85 day. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/8039147/full_citation L2 - https://medlineplus.gov/dietaryfiber.html DB - PRIME DP - Unbound Medicine ER -