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Reduction of bacteriuria and pyuria after ingestion of cranberry juice.

Abstract

OBJECTIVE

To determine the effect of regular intake of cranberry juice beverage on bacteriuria and pyuria in elderly women.

DESIGN

Randomized, double-blind, placebo-controlled trial.

SUBJECTS

Volunteer sample of 153 elderly women (mean age, 78.5 years).

INTERVENTION

Subjects were randomly assigned to consume 300 mL per day of a commercially available standard cranberry beverage or a specially prepared synthetic placebo drink that was indistinguishable in taste, appearance, and vitamin C content but lacked cranberry content.

OUTCOME MEASURES

A baseline urine sample and six clean-voided study urine samples were collected at approximately 1-month intervals and tested quantitatively for bacteriuria and the presence of white blood cells.

RESULTS

Subjects randomized to the cranberry beverage had odds of bacteriuria (defined as organisms numbering > or = 10(5)/mL) with pyuria that were only 42% of the odds in the control group (P = .004). Their odds of remaining bacteriuric-pyuric, given that they were bacteriuric-pyuric in the previous month, were only 27% of the odds in the control group (P = .006).

CONCLUSIONS

These findings suggest that use of a cranberry beverage reduces the frequency of bacteriuria with pyuria in older women. Prevalent beliefs about the effects of cranberry juice on the urinary tract may have microbiologic justification.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Program for the Analysis of Clinical Strategies, Brigham and Women's Hospital, Boston, MA 02115.

    , , , ,

    Source

    JAMA 271:10 1994 Mar 09 pg 751-4

    MeSH

    Aged
    Aged, 80 and over
    Bacteriuria
    Beverages
    Double-Blind Method
    Female
    Fruit
    Humans
    Pyuria
    Urinalysis

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    8093138

    Citation

    Avorn, J, et al. "Reduction of Bacteriuria and Pyuria After Ingestion of Cranberry Juice." JAMA, vol. 271, no. 10, 1994, pp. 751-4.
    Avorn J, Monane M, Gurwitz JH, et al. Reduction of bacteriuria and pyuria after ingestion of cranberry juice. JAMA. 1994;271(10):751-4.
    Avorn, J., Monane, M., Gurwitz, J. H., Glynn, R. J., Choodnovskiy, I., & Lipsitz, L. A. (1994). Reduction of bacteriuria and pyuria after ingestion of cranberry juice. JAMA, 271(10), pp. 751-4.
    Avorn J, et al. Reduction of Bacteriuria and Pyuria After Ingestion of Cranberry Juice. JAMA. 1994 Mar 9;271(10):751-4. PubMed PMID: 8093138.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Reduction of bacteriuria and pyuria after ingestion of cranberry juice. AU - Avorn,J, AU - Monane,M, AU - Gurwitz,J H, AU - Glynn,R J, AU - Choodnovskiy,I, AU - Lipsitz,L A, PY - 1994/3/9/pubmed PY - 1994/3/9/medline PY - 1994/3/9/entrez SP - 751 EP - 4 JF - JAMA JO - JAMA VL - 271 IS - 10 N2 - OBJECTIVE: To determine the effect of regular intake of cranberry juice beverage on bacteriuria and pyuria in elderly women. DESIGN: Randomized, double-blind, placebo-controlled trial. SUBJECTS: Volunteer sample of 153 elderly women (mean age, 78.5 years). INTERVENTION: Subjects were randomly assigned to consume 300 mL per day of a commercially available standard cranberry beverage or a specially prepared synthetic placebo drink that was indistinguishable in taste, appearance, and vitamin C content but lacked cranberry content. OUTCOME MEASURES: A baseline urine sample and six clean-voided study urine samples were collected at approximately 1-month intervals and tested quantitatively for bacteriuria and the presence of white blood cells. RESULTS: Subjects randomized to the cranberry beverage had odds of bacteriuria (defined as organisms numbering > or = 10(5)/mL) with pyuria that were only 42% of the odds in the control group (P = .004). Their odds of remaining bacteriuric-pyuric, given that they were bacteriuric-pyuric in the previous month, were only 27% of the odds in the control group (P = .006). CONCLUSIONS: These findings suggest that use of a cranberry beverage reduces the frequency of bacteriuria with pyuria in older women. Prevalent beliefs about the effects of cranberry juice on the urinary tract may have microbiologic justification. SN - 0098-7484 UR - https://www.unboundmedicine.com/medline/citation/8093138/full_citation L2 - https://jamanetwork.com/journals/jama/fullarticle/vol/271/pg/751 DB - PRIME DP - Unbound Medicine ER -