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Low-fat, high-fiber diet favorably affects several independent risk markers of ischemic heart disease: observations on blood lipids, coagulation, and fibrinolysis from a trial of middle-aged Danes.
Am J Clin Nutr 1994; 59(4):935-9AJ

Abstract

We served a low-fat (28% of energy), high-fiber (3.3 g/MJ) diet according to Nordic nutrition recommendations (Rec diet), and a high-fat diet (39% of energy) corresponding to the average Danish diet (Dane diet) for periods of 2 wk in a randomized crossover study of 21 healthy middle-aged individuals. The Rec diet resulted in lower serum concentrations of low-density-lipoprotein (LDL) cholesterol (medians: 2.77 vs 3.04 mmol/L, P < 0.001) and high-density-lipoprotein (HDL) cholesterol (1.08 vs 1.24 mmol/L, P < 0.001), and higher fasting triglycerides (1.11 vs 0.86 mmol/L, P = 0.04) than did the Dane diet. Furthermore, the Rec diet lowered plasma factor VII coagulant activity (FVIIc) (88% vs 96%, P = 0.002) and raised plasma fibrinolytic activity. Our observations indicate that a low-fat, high-fiber diet may not only reduce the atherogenic but also the thrombogenic tendency of an individual compared with a diet corresponding to the average Danish diet.

Authors+Show Affiliations

Research Department of Human Nutrition, Royal Veterinary and Agricultural University, Frederiksberg, Denmark.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8147341

Citation

Marckmann, P, et al. "Low-fat, High-fiber Diet Favorably Affects Several Independent Risk Markers of Ischemic Heart Disease: Observations On Blood Lipids, Coagulation, and Fibrinolysis From a Trial of Middle-aged Danes." The American Journal of Clinical Nutrition, vol. 59, no. 4, 1994, pp. 935-9.
Marckmann P, Sandström B, Jespersen J. Low-fat, high-fiber diet favorably affects several independent risk markers of ischemic heart disease: observations on blood lipids, coagulation, and fibrinolysis from a trial of middle-aged Danes. Am J Clin Nutr. 1994;59(4):935-9.
Marckmann, P., Sandström, B., & Jespersen, J. (1994). Low-fat, high-fiber diet favorably affects several independent risk markers of ischemic heart disease: observations on blood lipids, coagulation, and fibrinolysis from a trial of middle-aged Danes. The American Journal of Clinical Nutrition, 59(4), pp. 935-9.
Marckmann P, Sandström B, Jespersen J. Low-fat, High-fiber Diet Favorably Affects Several Independent Risk Markers of Ischemic Heart Disease: Observations On Blood Lipids, Coagulation, and Fibrinolysis From a Trial of Middle-aged Danes. Am J Clin Nutr. 1994;59(4):935-9. PubMed PMID: 8147341.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low-fat, high-fiber diet favorably affects several independent risk markers of ischemic heart disease: observations on blood lipids, coagulation, and fibrinolysis from a trial of middle-aged Danes. AU - Marckmann,P, AU - Sandström,B, AU - Jespersen,J, PY - 1994/4/1/pubmed PY - 1994/4/1/medline PY - 1994/4/1/entrez SP - 935 EP - 9 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 59 IS - 4 N2 - We served a low-fat (28% of energy), high-fiber (3.3 g/MJ) diet according to Nordic nutrition recommendations (Rec diet), and a high-fat diet (39% of energy) corresponding to the average Danish diet (Dane diet) for periods of 2 wk in a randomized crossover study of 21 healthy middle-aged individuals. The Rec diet resulted in lower serum concentrations of low-density-lipoprotein (LDL) cholesterol (medians: 2.77 vs 3.04 mmol/L, P < 0.001) and high-density-lipoprotein (HDL) cholesterol (1.08 vs 1.24 mmol/L, P < 0.001), and higher fasting triglycerides (1.11 vs 0.86 mmol/L, P = 0.04) than did the Dane diet. Furthermore, the Rec diet lowered plasma factor VII coagulant activity (FVIIc) (88% vs 96%, P = 0.002) and raised plasma fibrinolytic activity. Our observations indicate that a low-fat, high-fiber diet may not only reduce the atherogenic but also the thrombogenic tendency of an individual compared with a diet corresponding to the average Danish diet. SN - 0002-9165 UR - http://www.unboundmedicine.com/medline/citation/8147341/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/59.4.935 DB - PRIME DP - Unbound Medicine ER -