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Low-fat, high-fiber diet favorably affects several independent risk markers of ischemic heart disease: observations on blood lipids, coagulation, and fibrinolysis from a trial of middle-aged Danes.

Abstract

We served a low-fat (28% of energy), high-fiber (3.3 g/MJ) diet according to Nordic nutrition recommendations (Rec diet), and a high-fat diet (39% of energy) corresponding to the average Danish diet (Dane diet) for periods of 2 wk in a randomized crossover study of 21 healthy middle-aged individuals. The Rec diet resulted in lower serum concentrations of low-density-lipoprotein (LDL) cholesterol (medians: 2.77 vs 3.04 mmol/L, P < 0.001) and high-density-lipoprotein (HDL) cholesterol (1.08 vs 1.24 mmol/L, P < 0.001), and higher fasting triglycerides (1.11 vs 0.86 mmol/L, P = 0.04) than did the Dane diet. Furthermore, the Rec diet lowered plasma factor VII coagulant activity (FVIIc) (88% vs 96%, P = 0.002) and raised plasma fibrinolytic activity. Our observations indicate that a low-fat, high-fiber diet may not only reduce the atherogenic but also the thrombogenic tendency of an individual compared with a diet corresponding to the average Danish diet.

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  • Authors+Show Affiliations

    ,

    Research Department of Human Nutrition, Royal Veterinary and Agricultural University, Frederiksberg, Denmark.

    ,

    Source

    MeSH

    Blood Coagulation
    Dietary Fats
    Dietary Fiber
    Female
    Fibrinolysis
    Humans
    Lipids
    Male
    Middle Aged
    Myocardial Ischemia

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    8147341

    Citation

    Marckmann, P, et al. "Low-fat, High-fiber Diet Favorably Affects Several Independent Risk Markers of Ischemic Heart Disease: Observations On Blood Lipids, Coagulation, and Fibrinolysis From a Trial of Middle-aged Danes." The American Journal of Clinical Nutrition, vol. 59, no. 4, 1994, pp. 935-9.
    Marckmann P, Sandström B, Jespersen J. Low-fat, high-fiber diet favorably affects several independent risk markers of ischemic heart disease: observations on blood lipids, coagulation, and fibrinolysis from a trial of middle-aged Danes. Am J Clin Nutr. 1994;59(4):935-9.
    Marckmann, P., Sandström, B., & Jespersen, J. (1994). Low-fat, high-fiber diet favorably affects several independent risk markers of ischemic heart disease: observations on blood lipids, coagulation, and fibrinolysis from a trial of middle-aged Danes. The American Journal of Clinical Nutrition, 59(4), pp. 935-9.
    Marckmann P, Sandström B, Jespersen J. Low-fat, High-fiber Diet Favorably Affects Several Independent Risk Markers of Ischemic Heart Disease: Observations On Blood Lipids, Coagulation, and Fibrinolysis From a Trial of Middle-aged Danes. Am J Clin Nutr. 1994;59(4):935-9. PubMed PMID: 8147341.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Low-fat, high-fiber diet favorably affects several independent risk markers of ischemic heart disease: observations on blood lipids, coagulation, and fibrinolysis from a trial of middle-aged Danes. AU - Marckmann,P, AU - Sandström,B, AU - Jespersen,J, PY - 1994/4/1/pubmed PY - 1994/4/1/medline PY - 1994/4/1/entrez SP - 935 EP - 9 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 59 IS - 4 N2 - We served a low-fat (28% of energy), high-fiber (3.3 g/MJ) diet according to Nordic nutrition recommendations (Rec diet), and a high-fat diet (39% of energy) corresponding to the average Danish diet (Dane diet) for periods of 2 wk in a randomized crossover study of 21 healthy middle-aged individuals. The Rec diet resulted in lower serum concentrations of low-density-lipoprotein (LDL) cholesterol (medians: 2.77 vs 3.04 mmol/L, P < 0.001) and high-density-lipoprotein (HDL) cholesterol (1.08 vs 1.24 mmol/L, P < 0.001), and higher fasting triglycerides (1.11 vs 0.86 mmol/L, P = 0.04) than did the Dane diet. Furthermore, the Rec diet lowered plasma factor VII coagulant activity (FVIIc) (88% vs 96%, P = 0.002) and raised plasma fibrinolytic activity. Our observations indicate that a low-fat, high-fiber diet may not only reduce the atherogenic but also the thrombogenic tendency of an individual compared with a diet corresponding to the average Danish diet. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/8147341/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/59.4.935 DB - PRIME DP - Unbound Medicine ER -