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Processed meats and risk of childhood leukemia (California, USA).
Cancer Causes Control 1994; 5(2):195-202CC

Abstract

The relation between the intake of certain food items thought to be precursors or inhibitors of N-nitroso compounds (NOC) and risk of leukemia was investigated in a case-control study among children from birth to age 10 years in Los Angeles County, California (United States). Cases were ascertained through a population-based tumor registry from 1980 to 1987. Controls were drawn from friends and by random-digit dialing. Interviews were obtained from 232 cases and 232 controls. Food items of principal interest were: breakfast meats (bacon, sausage, ham); luncheon meats (salami, pastrami, lunch meat, corned beef, bologna); hot dogs; oranges and orange juice; and grapefruit and grapefruit juice. We also asked about intake of apples and apple juice, regular and charcoal broiled meats, milk, coffee, and coke or cola drinks. Usual consumption frequencies were determined for both parents and the child. When the risks were adjusted for each other and other risk factors, the only persistent significant associations were for children's intake of hot dogs (odds ratio [OR] = 9.5, 95 percent confidence interval [CI] = 1.6-57.6 for 12 or more hot dogs per month, trend P = 0.01), and fathers' intake of hot dogs (OR = 11.0, CI = 1.2-98.7 for highest intake category, trend P = 0.01). There was no evidence that fruit intake provided protection. While these results are compatible with the experimental animal literature and the hypothesis that human NOC intake is associated with leukemia risk, given potential biases in the data, further study of this hypothesis with more focused and comprehensive epidemiologic studies is warranted.

Authors+Show Affiliations

University of Southern California School of Medicine, Los Angeles 90033.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8167267

Citation

Peters, J M., et al. "Processed Meats and Risk of Childhood Leukemia (California, USA)." Cancer Causes & Control : CCC, vol. 5, no. 2, 1994, pp. 195-202.
Peters JM, Preston-Martin S, London SJ, et al. Processed meats and risk of childhood leukemia (California, USA). Cancer Causes Control. 1994;5(2):195-202.
Peters, J. M., Preston-Martin, S., London, S. J., Bowman, J. D., Buckley, J. D., & Thomas, D. C. (1994). Processed meats and risk of childhood leukemia (California, USA). Cancer Causes & Control : CCC, 5(2), pp. 195-202.
Peters JM, et al. Processed Meats and Risk of Childhood Leukemia (California, USA). Cancer Causes Control. 1994;5(2):195-202. PubMed PMID: 8167267.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Processed meats and risk of childhood leukemia (California, USA). AU - Peters,J M, AU - Preston-Martin,S, AU - London,S J, AU - Bowman,J D, AU - Buckley,J D, AU - Thomas,D C, PY - 1994/3/1/pubmed PY - 1994/3/1/medline PY - 1994/3/1/entrez SP - 195 EP - 202 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 5 IS - 2 N2 - The relation between the intake of certain food items thought to be precursors or inhibitors of N-nitroso compounds (NOC) and risk of leukemia was investigated in a case-control study among children from birth to age 10 years in Los Angeles County, California (United States). Cases were ascertained through a population-based tumor registry from 1980 to 1987. Controls were drawn from friends and by random-digit dialing. Interviews were obtained from 232 cases and 232 controls. Food items of principal interest were: breakfast meats (bacon, sausage, ham); luncheon meats (salami, pastrami, lunch meat, corned beef, bologna); hot dogs; oranges and orange juice; and grapefruit and grapefruit juice. We also asked about intake of apples and apple juice, regular and charcoal broiled meats, milk, coffee, and coke or cola drinks. Usual consumption frequencies were determined for both parents and the child. When the risks were adjusted for each other and other risk factors, the only persistent significant associations were for children's intake of hot dogs (odds ratio [OR] = 9.5, 95 percent confidence interval [CI] = 1.6-57.6 for 12 or more hot dogs per month, trend P = 0.01), and fathers' intake of hot dogs (OR = 11.0, CI = 1.2-98.7 for highest intake category, trend P = 0.01). There was no evidence that fruit intake provided protection. While these results are compatible with the experimental animal literature and the hypothesis that human NOC intake is associated with leukemia risk, given potential biases in the data, further study of this hypothesis with more focused and comprehensive epidemiologic studies is warranted. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/8167267/full_citation L2 - https://medlineplus.gov/leukemia.html DB - PRIME DP - Unbound Medicine ER -