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Family history and risk of primary open angle glaucoma. The Baltimore Eye Survey.

Abstract

OBJECTIVE

Primary open angle glaucoma has been previously associated with a positive family history of glaucoma. We used data from the Baltimore Eye Survey to examine this association.

DESIGN

A population-based prevalence survey identified 161 cases of primary open angle glaucoma among 5308 black and white residents of east Baltimore, Md, who were 40 years of age or older. Family history was ascertained by interview and included all first-degree relatives (parents, siblings, and children).

RESULTS

Age-adjusted associations of primary open angle glaucoma with a history of glaucoma were higher in siblings (odds ratio [OR] = 3.69) than in parents (OR = 2.17) or children (OR = 1.12). Odds ratios were slightly higher in blacks than in whites, and there was evidence of selection bias, with ORs between two and three times higher for those who had prior knowledge of their glaucoma diagnosis than for those who first received their diagnosis by the study examination (history in siblings OR = 4.72 for those with prior knowledge vs 2.77 for those without).

CONCLUSION

Family history is an important risk factor for primary open angle glaucoma, although clinic-based studies are likely to overstate its impact.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Dana Center for Preventive Ophthalmology, Wilmer Eye Institute, Johns Hopkins University Schools of Medicine and Public Health, Baltimore, Md.

    , , ,

    Source

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Baltimore
    Family Health
    Female
    Glaucoma, Open-Angle
    Humans
    Male
    Medical History Taking
    Middle Aged
    Odds Ratio
    Prevalence
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    8285897

    Citation

    Tielsch, J M., et al. "Family History and Risk of Primary Open Angle Glaucoma. the Baltimore Eye Survey." Archives of Ophthalmology (Chicago, Ill. : 1960), vol. 112, no. 1, 1994, pp. 69-73.
    Tielsch JM, Katz J, Sommer A, et al. Family history and risk of primary open angle glaucoma. The Baltimore Eye Survey. Arch Ophthalmol. 1994;112(1):69-73.
    Tielsch, J. M., Katz, J., Sommer, A., Quigley, H. A., & Javitt, J. C. (1994). Family history and risk of primary open angle glaucoma. The Baltimore Eye Survey. Archives of Ophthalmology (Chicago, Ill. : 1960), 112(1), pp. 69-73.
    Tielsch JM, et al. Family History and Risk of Primary Open Angle Glaucoma. the Baltimore Eye Survey. Arch Ophthalmol. 1994;112(1):69-73. PubMed PMID: 8285897.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Family history and risk of primary open angle glaucoma. The Baltimore Eye Survey. AU - Tielsch,J M, AU - Katz,J, AU - Sommer,A, AU - Quigley,H A, AU - Javitt,J C, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 69 EP - 73 JF - Archives of ophthalmology (Chicago, Ill. : 1960) JO - Arch. Ophthalmol. VL - 112 IS - 1 N2 - OBJECTIVE: Primary open angle glaucoma has been previously associated with a positive family history of glaucoma. We used data from the Baltimore Eye Survey to examine this association. DESIGN: A population-based prevalence survey identified 161 cases of primary open angle glaucoma among 5308 black and white residents of east Baltimore, Md, who were 40 years of age or older. Family history was ascertained by interview and included all first-degree relatives (parents, siblings, and children). RESULTS: Age-adjusted associations of primary open angle glaucoma with a history of glaucoma were higher in siblings (odds ratio [OR] = 3.69) than in parents (OR = 2.17) or children (OR = 1.12). Odds ratios were slightly higher in blacks than in whites, and there was evidence of selection bias, with ORs between two and three times higher for those who had prior knowledge of their glaucoma diagnosis than for those who first received their diagnosis by the study examination (history in siblings OR = 4.72 for those with prior knowledge vs 2.77 for those without). CONCLUSION: Family history is an important risk factor for primary open angle glaucoma, although clinic-based studies are likely to overstate its impact. SN - 0003-9950 UR - https://www.unboundmedicine.com/medline/citation/8285897/full_citation L2 - https://jamanetwork.com/journals/jamaophthalmology/fullarticle/vol/112/pg/69 DB - PRIME DP - Unbound Medicine ER -