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Markers of slow-healing peptic ulcer in the elderly. A study on 1,052 ranitidine-treated patients.

Abstract

Little is known about ulcer outcome in the elderly. The aims of the present paper were to establish whether risk factors of slow-healing peptic ulcer can be demonstrated in the elderly and whether clinical differences exist between ulcer patients whose age of onset of the disease was before or after 65 years old. The short-term, open study, involving 1052 elderly patients (over 65 years) in 37 gastroenterology centers throughout Italy aimed to compare two schedules of ranitidine treatment: 150 mg twice daily versus 300 mg at bedtime. As nonsignificant differences were found between these two schedules, the sample was considered as a whole. It included 319 gastric ulcer (GU) patients, 699 duodenal ulcer (DU) patients, and 34 concomitant GU and DU cases. Ninety-three patients dropped out of the trial; 79/294 GU, 138/635 DU, and 10/30 GU+DU were found still unhealed after four weeks and 20 GU, 15 DU, and 1 GU+DU remained so after eight weeks. Statistical analysis was performed using likelihood-ratio and Pearson's chi-squared tests and Cox's models. Univariate analysis showed that the indicators of slow-healing GU were ulcer size (P = 0.002) and persisting ulcer symptoms (P = 0.0001); indicators of slow-healing DU were ulcer size (P = 0.0001), persisting ulcer symptoms (P = 0.0001), alcohol (P = 0.0003), and NSAID (P = 0.0088) consumption. DU patients taking antiplatelet drugs have significantly better results after four weeks and worse results after eight weeks (P = 0.0352).(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

,

Servizio di Gastroenterologia, Ospedale, SS. Giovanni e Paolo, Venezia.

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Source

Digestive diseases and sciences 38:8 1993 Aug pg 1414-21

MeSH

Age Factors
Aged
Alcohol Drinking
Anti-Inflammatory Agents, Non-Steroidal
Drug Administration Schedule
Duodenal Ulcer
Female
Humans
Male
Middle Aged
Multivariate Analysis
Ranitidine
Risk Factors
Stomach Ulcer
Treatment Outcome
Wound Healing

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8344096

Citation

Battaglia, G, et al. "Markers of Slow-healing Peptic Ulcer in the Elderly. a Study On 1,052 Ranitidine-treated Patients." Digestive Diseases and Sciences, vol. 38, no. 8, 1993, pp. 1414-21.
Battaglia G, Di Mario F, Dotto P, et al. Markers of slow-healing peptic ulcer in the elderly. A study on 1,052 ranitidine-treated patients. Dig Dis Sci. 1993;38(8):1414-21.
Battaglia, G., Di Mario, F., Dotto, P., Leandro, G., Pilotto, A., Ferrana, M., ... Naccarato, R. (1993). Markers of slow-healing peptic ulcer in the elderly. A study on 1,052 ranitidine-treated patients. Digestive Diseases and Sciences, 38(8), pp. 1414-21.
Battaglia G, et al. Markers of Slow-healing Peptic Ulcer in the Elderly. a Study On 1,052 Ranitidine-treated Patients. Dig Dis Sci. 1993;38(8):1414-21. PubMed PMID: 8344096.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Markers of slow-healing peptic ulcer in the elderly. A study on 1,052 ranitidine-treated patients. AU - Battaglia,G, AU - Di Mario,F, AU - Dotto,P, AU - Leandro,G, AU - Pilotto,A, AU - Ferrana,M, AU - Vianello,F, AU - Vigneri,S, AU - Colonna,C V, AU - Naccarato,R, PY - 1993/8/1/pubmed PY - 1993/8/1/medline PY - 1993/8/1/entrez SP - 1414 EP - 21 JF - Digestive diseases and sciences JO - Dig. Dis. Sci. VL - 38 IS - 8 N2 - Little is known about ulcer outcome in the elderly. The aims of the present paper were to establish whether risk factors of slow-healing peptic ulcer can be demonstrated in the elderly and whether clinical differences exist between ulcer patients whose age of onset of the disease was before or after 65 years old. The short-term, open study, involving 1052 elderly patients (over 65 years) in 37 gastroenterology centers throughout Italy aimed to compare two schedules of ranitidine treatment: 150 mg twice daily versus 300 mg at bedtime. As nonsignificant differences were found between these two schedules, the sample was considered as a whole. It included 319 gastric ulcer (GU) patients, 699 duodenal ulcer (DU) patients, and 34 concomitant GU and DU cases. Ninety-three patients dropped out of the trial; 79/294 GU, 138/635 DU, and 10/30 GU+DU were found still unhealed after four weeks and 20 GU, 15 DU, and 1 GU+DU remained so after eight weeks. Statistical analysis was performed using likelihood-ratio and Pearson's chi-squared tests and Cox's models. Univariate analysis showed that the indicators of slow-healing GU were ulcer size (P = 0.002) and persisting ulcer symptoms (P = 0.0001); indicators of slow-healing DU were ulcer size (P = 0.0001), persisting ulcer symptoms (P = 0.0001), alcohol (P = 0.0003), and NSAID (P = 0.0088) consumption. DU patients taking antiplatelet drugs have significantly better results after four weeks and worse results after eight weeks (P = 0.0352).(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0163-2116 UR - https://www.unboundmedicine.com/medline/citation/8344096/full_citation DB - PRIME DP - Unbound Medicine ER -