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Ethanol inhibits melatonin secretion in healthy volunteers in a dose-dependent randomized double blind cross-over study.

Abstract

To elucidate the effects of alcohol on pineal rhythmicity, ethanol was administered in the evening in amounts usually consumed during social ingestion to nine healthy volunteers in a double blind, cross-over study. Plasma concentrations of melatonin, catecholamines (norepinephrine and epinephrine), and ethanol were measured by RIA, high pressure liquid chromatography, and gas chromatography before and for 12 h after the administration of 0, 0.5, and 1 g ethanol/kg wt. Plasma melatonin and catecholamines displayed expected diurnal rhythms, with peak values at 0300-0400 h for melatonin and trough values at 0100-0400 h for catecholamines. Intake of ethanol between 1900-1945 h inhibited the nocturnal melatonin secretion dose-dependently during the first half of the night, with no changes in urinary excretion of melatonin. The inhibition was 41% (P < 0.05) from the control at midnight for both ethanol doses, 33% (P < 0.05) at 0100 h, and 18% (P < 0.05) at 0200 h for the higher dose. In addition, the higher dose of ethanol increased plasma norepinephrine levels at 2000 and 2200 h (P < 0.01) until 0400 h (P < 0.05). Taking into account the involvement of melatonin in the regulation of sleep and diurnal rhythms, we suggest that ethanol-induced suppression of nocturnal melatonin secretion and an increase in noradrenergic activity may be closely associated with disturbances in sleep and performance.

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  • Authors+Show Affiliations

    ,

    Department of Physiology, University of Oulu, Finland.

    , , ,

    Source

    MeSH

    Adult
    Circadian Rhythm
    Dose-Response Relationship, Drug
    Double-Blind Method
    Epinephrine
    Ethanol
    Female
    Humans
    Kinetics
    Male
    Melatonin
    Norepinephrine
    Random Allocation

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    8370699

    Citation

    Ekman, A C., et al. "Ethanol Inhibits Melatonin Secretion in Healthy Volunteers in a Dose-dependent Randomized Double Blind Cross-over Study." The Journal of Clinical Endocrinology and Metabolism, vol. 77, no. 3, 1993, pp. 780-3.
    Ekman AC, Leppäluoto J, Huttunen P, et al. Ethanol inhibits melatonin secretion in healthy volunteers in a dose-dependent randomized double blind cross-over study. J Clin Endocrinol Metab. 1993;77(3):780-3.
    Ekman, A. C., Leppäluoto, J., Huttunen, P., Aranko, K., & Vakkuri, O. (1993). Ethanol inhibits melatonin secretion in healthy volunteers in a dose-dependent randomized double blind cross-over study. The Journal of Clinical Endocrinology and Metabolism, 77(3), pp. 780-3.
    Ekman AC, et al. Ethanol Inhibits Melatonin Secretion in Healthy Volunteers in a Dose-dependent Randomized Double Blind Cross-over Study. J Clin Endocrinol Metab. 1993;77(3):780-3. PubMed PMID: 8370699.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Ethanol inhibits melatonin secretion in healthy volunteers in a dose-dependent randomized double blind cross-over study. AU - Ekman,A C, AU - Leppäluoto,J, AU - Huttunen,P, AU - Aranko,K, AU - Vakkuri,O, PY - 1993/9/1/pubmed PY - 1993/9/1/medline PY - 1993/9/1/entrez SP - 780 EP - 3 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 77 IS - 3 N2 - To elucidate the effects of alcohol on pineal rhythmicity, ethanol was administered in the evening in amounts usually consumed during social ingestion to nine healthy volunteers in a double blind, cross-over study. Plasma concentrations of melatonin, catecholamines (norepinephrine and epinephrine), and ethanol were measured by RIA, high pressure liquid chromatography, and gas chromatography before and for 12 h after the administration of 0, 0.5, and 1 g ethanol/kg wt. Plasma melatonin and catecholamines displayed expected diurnal rhythms, with peak values at 0300-0400 h for melatonin and trough values at 0100-0400 h for catecholamines. Intake of ethanol between 1900-1945 h inhibited the nocturnal melatonin secretion dose-dependently during the first half of the night, with no changes in urinary excretion of melatonin. The inhibition was 41% (P < 0.05) from the control at midnight for both ethanol doses, 33% (P < 0.05) at 0100 h, and 18% (P < 0.05) at 0200 h for the higher dose. In addition, the higher dose of ethanol increased plasma norepinephrine levels at 2000 and 2200 h (P < 0.01) until 0400 h (P < 0.05). Taking into account the involvement of melatonin in the regulation of sleep and diurnal rhythms, we suggest that ethanol-induced suppression of nocturnal melatonin secretion and an increase in noradrenergic activity may be closely associated with disturbances in sleep and performance. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/8370699/full_citation L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem.77.3.8370699 DB - PRIME DP - Unbound Medicine ER -