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Ethanol inhibits melatonin secretion in healthy volunteers in a dose-dependent randomized double blind cross-over study.
J Clin Endocrinol Metab 1993; 77(3):780-3JC

Abstract

To elucidate the effects of alcohol on pineal rhythmicity, ethanol was administered in the evening in amounts usually consumed during social ingestion to nine healthy volunteers in a double blind, cross-over study. Plasma concentrations of melatonin, catecholamines (norepinephrine and epinephrine), and ethanol were measured by RIA, high pressure liquid chromatography, and gas chromatography before and for 12 h after the administration of 0, 0.5, and 1 g ethanol/kg wt. Plasma melatonin and catecholamines displayed expected diurnal rhythms, with peak values at 0300-0400 h for melatonin and trough values at 0100-0400 h for catecholamines. Intake of ethanol between 1900-1945 h inhibited the nocturnal melatonin secretion dose-dependently during the first half of the night, with no changes in urinary excretion of melatonin. The inhibition was 41% (P < 0.05) from the control at midnight for both ethanol doses, 33% (P < 0.05) at 0100 h, and 18% (P < 0.05) at 0200 h for the higher dose. In addition, the higher dose of ethanol increased plasma norepinephrine levels at 2000 and 2200 h (P < 0.01) until 0400 h (P < 0.05). Taking into account the involvement of melatonin in the regulation of sleep and diurnal rhythms, we suggest that ethanol-induced suppression of nocturnal melatonin secretion and an increase in noradrenergic activity may be closely associated with disturbances in sleep and performance.

Authors+Show Affiliations

Department of Physiology, University of Oulu, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8370699

Citation

Ekman, A C., et al. "Ethanol Inhibits Melatonin Secretion in Healthy Volunteers in a Dose-dependent Randomized Double Blind Cross-over Study." The Journal of Clinical Endocrinology and Metabolism, vol. 77, no. 3, 1993, pp. 780-3.
Ekman AC, Leppäluoto J, Huttunen P, et al. Ethanol inhibits melatonin secretion in healthy volunteers in a dose-dependent randomized double blind cross-over study. J Clin Endocrinol Metab. 1993;77(3):780-3.
Ekman, A. C., Leppäluoto, J., Huttunen, P., Aranko, K., & Vakkuri, O. (1993). Ethanol inhibits melatonin secretion in healthy volunteers in a dose-dependent randomized double blind cross-over study. The Journal of Clinical Endocrinology and Metabolism, 77(3), pp. 780-3.
Ekman AC, et al. Ethanol Inhibits Melatonin Secretion in Healthy Volunteers in a Dose-dependent Randomized Double Blind Cross-over Study. J Clin Endocrinol Metab. 1993;77(3):780-3. PubMed PMID: 8370699.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ethanol inhibits melatonin secretion in healthy volunteers in a dose-dependent randomized double blind cross-over study. AU - Ekman,A C, AU - Leppäluoto,J, AU - Huttunen,P, AU - Aranko,K, AU - Vakkuri,O, PY - 1993/9/1/pubmed PY - 1993/9/1/medline PY - 1993/9/1/entrez SP - 780 EP - 3 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 77 IS - 3 N2 - To elucidate the effects of alcohol on pineal rhythmicity, ethanol was administered in the evening in amounts usually consumed during social ingestion to nine healthy volunteers in a double blind, cross-over study. Plasma concentrations of melatonin, catecholamines (norepinephrine and epinephrine), and ethanol were measured by RIA, high pressure liquid chromatography, and gas chromatography before and for 12 h after the administration of 0, 0.5, and 1 g ethanol/kg wt. Plasma melatonin and catecholamines displayed expected diurnal rhythms, with peak values at 0300-0400 h for melatonin and trough values at 0100-0400 h for catecholamines. Intake of ethanol between 1900-1945 h inhibited the nocturnal melatonin secretion dose-dependently during the first half of the night, with no changes in urinary excretion of melatonin. The inhibition was 41% (P < 0.05) from the control at midnight for both ethanol doses, 33% (P < 0.05) at 0100 h, and 18% (P < 0.05) at 0200 h for the higher dose. In addition, the higher dose of ethanol increased plasma norepinephrine levels at 2000 and 2200 h (P < 0.01) until 0400 h (P < 0.05). Taking into account the involvement of melatonin in the regulation of sleep and diurnal rhythms, we suggest that ethanol-induced suppression of nocturnal melatonin secretion and an increase in noradrenergic activity may be closely associated with disturbances in sleep and performance. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/8370699/full_citation L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem.77.3.8370699 DB - PRIME DP - Unbound Medicine ER -